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Mitochondrial NRG

Designs for Health
4.8
★ ★ ★ ★ ★
(86 ratings)
Vitamin B12 2000 mcg
Thiamin 50 mg
Riboflavin 10 mg
Vitamin B5 50 mg
Coenzyme Q-10 100 mg
Resveratrol 100 mg
L-Carnitine 200 mg
Product Image
Score69
A well-designed mitochondrial blend with strong forms and broad coverage, tempered by low amounts of several supporting actives and a high serving cost.
How scoring works
Quantity:120 Capsule(s) • (30 servings)
Goals:
Energy
Metabolism Boost
Heart Health
General Health
Brain Health
Anti-Aging
Cardiovascular Support
Anti-Inflammatory Support

Score 69

A well-designed mitochondrial blend with strong forms and broad coverage, tempered by low amounts of several supporting actives and a high serving cost.
How scoring works
$83.99($2.79 per serving)
iHerb
$ 83.99
Pure Formulas
$ 83.99
Report prices

Analysis

Methylcobalamin, riboflavin 5-phosphate, thiamine, CoQ10, and alpha-lipoic acid form a credible cellular-energy core. Ingredient forms and amounts are generally well disclosed, which makes the formula easier to assess.

Several complementary compounds are spread thinly across the serving. Creatine, carnitine, ribose, magnesium, and organic acids fall well below amounts usually chosen for focused use, while dry-capsule ubiquinone lacks a lipid carrier.

Resveratrol and curcumin broaden antioxidant and inflammatory-pathway support, though neither has a clear absorption aid. It fits users who value a broad mitochondrial stack and accept that several ingredients play supporting rather than primary roles.

Who is it for
  • Adults seeking broad mitochondrial support
  • People who prefer active B-vitamin forms
  • Users wanting energy and antioxidant ingredients in one formula
Best for
  • Cellular energy support
  • Broad mitochondrial coverage
  • Active B-vitamin supplementation

Pros

  • Uses methylcobalamin and riboflavin 5-phosphate
  • Provides 100 mg CoQ10 and 100 mg alpha-lipoic acid
  • Covers several mitochondrial pathways
  • Clearly discloses most forms and amounts

Cons

  • Creatine and carnitine are low for targeted use
  • Dry-capsule CoQ10 has no lipid carrier
  • Curcumin has no stated absorption enhancer
  • Serving cost is high

Warnings

  • Curcumin and resveratrol may add to bleeding risk when used with anticoagulant or antiplatelet medicines
  • High-dose methylcobalamin may be unnecessary for people without increased B12 needs
  • Four capsules per serving may be inconvenient for users who struggle with pills

Nutrient quality

75 High impact

Bioavailable B vitamins and a meaningful coenzyme Q10 dose provide a strong foundation. Several headline energy substrates are modestly dosed, which limits the formula depth.

.

Ingredient transparency

69 High impact

The main active amounts are generally available and no broad proprietary blend obscures the formula. Complete usage directions and non-active ingredients are not supplied, while any noted duplicate or vague entries reduce clarity.

.

Customer satisfaction

65 High impact

Aggregate satisfaction is very strong and supported by a moderate evidence base. No firsthand experience details are supplied, so recurring complaints and purpose alignment remain uncertain.

.

Value for money

63 Moderate impact

High-quality nutrient forms and a broad cofactor profile provide real formula value. Modest doses of several key substrates weaken competitiveness at the premium end of the category.

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Report analysis

Goals

Energy
Essential Energy Nutrients
Energy
Impact
Highest effect
A Goal FitB Strength of SupportB+ CoverageB+ Formula Quality
Vitamin B5 · 50 mgMagnesium · 100 mgRiboflavin · 10 mgThiamin · 50 mgVitamin B12 · 2000 mcgCoenzyme Q-10 · 100 mgCreatine · 550 mg

High-dose methylcobalamin, thiamine, active riboflavin, CoQ10, alpha-lipoic acid, carnitine, creatine chelate, and tricarboxylic-acid intermediates create direct mitochondrial relevance. The formula covers several steps in cellular fuel handling and antioxidant protection.

Creatine at 550 mg and carnitine at 200 mg are far below common focused amounts, while dry-capsule CoQ10 lacks a lipid carrier. The design is scientifically coherent but broader than its strongest doses support.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Creatine Supportive 49 studies
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
Metabolism Boost
Metabolic B-Vitamins
Metabolism Boost
Impact
High effect
B+ Goal FitB Strength of SupportB CoverageB Formula Quality
Niacin · 5 mgVitamin B12 · 2000 mcgRiboflavin · 10 mgThiamin · 50 mgVitamin B5 · 50 mgVitamin B6 · 5 mgMagnesium · 100 mgResveratrol · 100 mgCreatine · 550 mgCoenzyme Q-10 · 100 mg

A broad mitochondrial blend combines CoQ10, carnitine, active B-vitamin forms, alpha-lipoic acid, and resveratrol. The design is strongly aligned with cellular energy, though it is not built around thermogenesis.

CoQ10 and several cofactors reach useful amounts, while carnitine, creatine, ribose, and organic acids are modest for targeted effects. The large ingredient count creates some dilution, but full dose disclosure and several bioavailable forms preserve credibility.

Study evidence
Coenzyme Q-10 Disputed 11 studies
Creatine Supportive 21 studies
Resveratrol Supportive 21 studies
Heart Health
Heart Health
Impact
High effect
A- Goal FitB Strength of SupportB CoverageC+ Formula Quality
Magnesium · 100 mgCoenzyme Q-10 · 100 mgVitamin B12 · 2000 mcgVitamin B6 · 5 mg

CoQ10, B vitamins, L-carnitine, magnesium, and antioxidant compounds create a broad mitochondrial formula relevant to cardiac energy. Methylcobalamin and active B-vitamin forms strengthen the metabolic core.

Several actives, including carnitine, creatine, ribose, and magnesium, fall below focused amounts. Dry-capsule CoQ10 and duplicated curcumin entries also reduce the efficiency of this very broad stack.

Study evidence
Coenzyme Q-10 Supportive 114 studies
L-Carnitine Supportive 84 studies
Magnesium Supportive 158 studies
Vitamin B12 No effect 42 studies
General Health
General Health
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageB Formula Quality
Vitamin B12 · 2000 mcgMagnesium · 100 mgCreatine · 550 mg

Methylcobalamin, coenzyme Q10, alpha-lipoic acid, and active B-vitamin forms create a plausible cellular-energy formula. Several mechanisms relevant to daily vitality are represented.

Creatine, carnitine, ribose, and several supporting compounds are supplied far below common stand-alone amounts. The formula is transparent and coherent, but much of its breadth lacks enough depth to carry equal practical weight.

Study evidence
Creatine Supportive 42 studies
Vitamin B12 Adverse 66 studies
Brain Health
Essential Brain Nutrition
Brain Health
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageB- Formula Quality
Vitamin B12 · 2000 mcgVitamin B6 · 5 mgThiamin · 50 mgMagnesium · 100 mgCreatine · 550 mg

High-dose methylcobalamin, CoQ10, alpha-lipoic acid, B vitamins, and metabolic intermediates support neuronal energy and antioxidant defenses. Several active forms and branded materials improve disclosure and biological relevance.

Creatine, carnitine, ribose, and some mitochondrial intermediates are far below common standalone amounts. The formula offers unusually broad mitochondrial coverage, but much of that breadth lacks enough dose for a strong neurological effect.

Study evidence
Creatine Supportive 35 studies
Thiamin Supportive 48 studies
Vitamin B12 Supportive 74 studies
Anti-Aging
Anti-Aging
Impact
High effect
A- Goal FitC Strength of SupportB- CoverageB Formula Quality
Coenzyme Q-10 · 100 mgMagnesium · 100 mgVitamin B12 · 2000 mcgCreatine · 550 mg

CoQ10, alpha-lipoic acid, carnitine, resveratrol, curcumin, and B vitamins create broad mitochondrial and antioxidant support. The combination addresses several mechanisms relevant to maintaining cellular energy with age.

Many secondary actives are supplied below common focused amounts, including creatine and carnitine. The formula is conceptually strong but spreads its serving across so many ingredients that depth becomes uneven.

Study evidence
Creatine Supportive 31 studies
Resveratrol No effect 7 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride, Vitamin B1)
 50 mg
Riboflavin (Riboflavin 5-Phosphate, Vitamin B2)
 10 mg
Vitamin B3 (Niacinamide)
 5 mg
Vitamin B-6 (Pyridoxal 5-Phosphate)
 5 mg
Vitamin B12 (Methylcobalamin)
 2000 mcg
Magnesium (Creatine MagnaPower)
 100 mg
Manganese (TRAACS Manganese Glycinate Chelate)
 500 mcg
Creatine (Creatine MagnaPower Magnesium Creatine Chelate)
 550 mg
L-Carnitine (L-Carnitine Fumarate)
 200 mg
Fumaric Acid (L-Carnitine Fumarate)
 150 mg
D-Ribose
100 mg
Malic Acid
100 mg
Succinic Acid
100 mg
Natural Coenzyme Q10 (Ubiquinone)
 100 mg
Alpha Lipoic Acid
100 mg
Trans Resveratrol
100 mg
Curcumin C3 Complex(R) (Curcuminoids)
 100 mg
Pantethine
50 mg
Gluten Free Adults 18–50
Report overview
Vitamin B12 (Methylcobalamin) · 2000 mcg OverallScore79
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
+1

Bioactive methylcobalamin is clearly identified, while the swallowed capsule provides standard rather than optimized absorption. The 2,000 mcg amount reaches the high-potency range for greater needs. Cost per active amount remains unfavorable despite use of the preferred form.

View ingredientView products
Thiamin (Thiamine Hydrochloride, Vitamin B1) · 50 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

The clearly listed thiamine hydrochloride reaches the preferred high-potency range. Its broader mitochondrial blend adds several complementary compounds, though it does not improve the standard thiamin form itself. The high serving cost makes the active thiamin dose poor value.

View ingredientView products
Riboflavin (Riboflavin 5-Phosphate, Vitamin B2) · 10 mg OverallScore75
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyD+ Value

The bioactive R5P form and capsule delivery support efficient use of the listed riboflavin. The 10 mg amount is a maintenance-level dose rather than a high-potency serving. Premium form quality partly offsets the high serving cost.

View ingredientView products
Loading alternative details
77 Performance

Coenzymate B Complex Orange Flavored

Source Naturals
<p>Coenzyme riboflavin and B6 plus methylcobalamin and hydroxocobalamin give the B-vitamin core strong form quality. It offers broader active-form B support than the original, though its 12 mg CoQ10 amount cannot replace the original’s mitochondrial cofactors.</p>
83 Performance

Multi-B Benfotiamine 150 mg

BenfoComplete.com
<p>Benfotiamine and methylcobalamin strengthen the thiamine and B12 components while keeping the formula concise and sensibly dosed. It is a clearer B-complex choice than the original, but it does not provide CoQ10, carnitine, creatine, or the antioxidant blend.</p>
65 Performance

HeartBeat

NaturesPlus
<p>Plant sterols, methylfolate, methylcobalamin, selenium, carnitine, resveratrol, and CoQ10 align well with the original’s cardiovascular themes. The heart-focused design is more coherent for that goal, though carnitine, resveratrol, and CoQ10 amounts are modest and a proprietary botanical blend reduces transparency.</p>
63 Budget

Ultra B-100 Complex

Mason Natural
<p>A very low serving cost preserves broad coverage of thiamine, riboflavin, niacin, B6, B12, and pantothenic acid. It drops the original’s CoQ10, carnitine, creatine, and antioxidant blend, while 100 mg of pyridoxine makes long-term daily use a concern.</p>
79 Budget

B-100 Complex

21st Century
<p>Broad B-vitamin coverage comes at a much lower recurring cost, with substantial thiamine, riboflavin, niacin, B6, B12, and pantothenic acid amounts. Conventional forms and 100 mg of pyridoxine make it less refined and less suitable for prolonged unsupervised use than the original.</p>
76 Budget

B Complex

INNATE Response Formulas
<p>Moderate B-vitamin amounts offer a gentler and more economical way to support energy metabolism than the original’s large specialty blend. It lacks CoQ10, carnitine, creatine, and the antioxidant ingredients, and its pyridoxine and cyanocobalamin forms are basic.</p>
69 Value

Super B-Complex

Pure Synergy
<p>A balanced B-vitamin profile and 110 mg of choline provide practical energy-metabolism coverage at a much lower recurring cost. Several vitamin forms are unspecified and it omits the original’s dedicated CoQ10, carnitine, creatine, and antioxidant support.</p>
71 Value

B-100 Gels

Carlson
<p>Broad high-potency B-vitamin coverage and phosphatidylcholine come at a much lower recurring cost than the original’s specialty blend. Conventional forms, 100 mg pyridoxine, and high folate reduce long-term suitability, and the formula omits CoQ10, carnitine, creatine, and most antioxidants.</p>
71 Value

Liver Guard

Source Naturals
<p>N-acetyl cysteine, alpha-lipoic acid, turmeric, CoQ10, B vitamins, and antioxidant vitamins provide broad metabolic and antioxidant coverage for the cost. The formula is less focused on mitochondrial energy than the original, and duplicate entries plus aggressive vitamin amounts make the label harder to interpret.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  2. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  3. Vitamin B12 Supplementation: Is More Always Better?
    Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
    Narrative reviewEnergy forVitamin B12
  4. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  5. High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial.
    Bager P; Bossen L; Gantzel R; Grønbæk H · PloS one · 2024
    Randomized trial36 participantsEnergy forThiamin
  6. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  7. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  8. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  9. Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis.
    Deng H; Song T; Yin M; Xu K; Zhong Y; Mohd NB; Naharudin MNB; Yusof A; Fan X · The British journal of nutrition · 2026
    Meta-analysis24 studies pooledEnergy forCoenzyme Q-10
  10. The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-response Meta-Analysis of Randomized Controlled Trials.
    Mirrafiei A; Jayedi A; Shab-Bidar S · Clinical therapeutics · 2024
    Meta-analysis2,041 participants21 studies pooledCardiovascular Support forL-Carnitine
  11. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis.
    Shang R; Sun Z; Li H · BMC cardiovascular disorders · 2015
    Meta-analysis3,108 participants5 studies pooledCardiovascular Support forL-Carnitine
  12. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.
    Mahjabeen W; Khan DA; Mirza SA · Complementary therapies in medicine · 2022
    Randomized trial110 participantsAnti-Inflammatory Support forResveratrol
  13. Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials.
    Haghighatdoost F; Hariri M · European journal of clinical nutrition · 2020
    Meta-analysis658 participants15 studies pooledAnti-Inflammatory Support forResveratrol
  14. No Beneficial Effects of Resveratrol on the Metabolic Syndrome: A Randomized Placebo-Controlled Clinical Trial.
    Kjær TN; Ornstrup MJ; Poulsen MM; Stødkilde-Jørgensen H; Jessen N; Jørgensen JOL; Richelsen B; Pedersen SB · The Journal of clinical endocrinology and metabolism · 2017
    Randomized trial74 participantsAnti-Inflammatory Support forResveratrol
  15. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  16. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  17. Creatine supplementation during resistance training in older adults-a meta-analysis.
    Devries MC; Phillips SM · Medicine and science in sports and exercise · 2014
    Meta-analysis357 participantsAnti-Aging forCreatine
  18. Strategic creatine supplementation and resistance training in healthy older adults.
    Candow DG; Vogt E; Johannsmeyer S; Forbes SC; Farthing JP · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
    Randomized trial39 participantsAnti-Aging forCreatine
  19. Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis.
    Chilibeck PD; Kaviani M; Candow DG; Zello GA · Open access journal of sports medicine · 2020
    Meta-analysis721 participants22 studies pooledAnti-Aging forCreatine
  20. Changes in Fat Mass Following Creatine Supplementation and Resistance Training in Adults ≥50 Years of Age: A Meta-Analysis.
    Forbes SC; Candow DG; Krentz JR; Roberts MD; Young KC · Journal of functional morphology and kinesiology · 2021
    Meta-analysis609 participants19 studies pooledAnti-Aging forCreatine
  21. Creatine supplementation improves muscular performance in older men.
    Gotshalk LA; Volek JS; Staron RS; Denegar CR; Hagerman FC; Kraemer WJ · Medicine and science in sports and exercise · 2002
    Randomized trial18 participantsAnti-Aging forCreatine
  22. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults.
    Witte AV; Kerti L; Margulies DS; Flöel A · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Randomized trial46 participantsAnti-Aging forResveratrol
  23. Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial.
    Huhn S; Beyer F; Zhang R; Lampe L; Grothe J; Kratzsch J; Willenberg A; Breitfeld J; Kovacs P; Stumvoll M; Trampel R; Bazin PL; Villringer A; Witte AV · NeuroImage · 2019
    Randomized trial60 participantsAnti-Aging forResveratrol
  24. Resveratrol levels and all-cause mortality in older community-dwelling adults.
    Semba RD; Ferrucci L; Bartali B; Urpí-Sarda M; Zamora-Ros R; Sun K; Cherubini A; Bandinelli S; Andres-Lacueva C · JAMA internal medicine · 2014
    Cohort study783 participantsAnti-Aging forResveratrol
  25. Impact of Resveratrol Supplementation on Human Sirtuin 1: A Grading of Recommendations Assessment, Development and Evaluation-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.
    Mansouri F; Feliziani G; Bordoni L; Gabbianelli R · Journal of the Academy of Nutrition and Dietetics · 2025
    Meta-analysis11 studies pooledAnti-Aging forResveratrol
  26. Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
    Rao A; Briskey D; Roche G; Tremblay A; Da Silva Pinto M; Tompkins TA · Frontiers in aging · 2026
    Randomized trial134 participantsAnti-Aging Skin Health forResveratrol
  27. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.
    Taghizadeh S; Izadi A; Shirazi S; Parizad M; Pourghassem Gargari B · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021
    Randomized trial43 participantsAnti-Inflammatory Support forCoenzyme Q-10
  28. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome.
    Karamali M; Gholizadeh M · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Randomized trial55 participantsAnti-Inflammatory Support forCoenzyme Q-10
  29. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
    Hou S; Tian Z; Zhao D; Liang Y; Dai S; Ji Q; Fan Z; Liu Z; Liu M; Yang Y · Molecular nutrition & food research · 2023
    Meta-analysis1,517 participants31 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  30. Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials.
    Farsi F; Heshmati J; Keshtkar A; Irandoost P; Alamdari NM; Akbari A; Janani L; Morshedzadeh N; Vafa M · Pharmacological research · 2020
    Meta-analysis509 participants9 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  31. Promising efficacy of coenzyme Q10 supplementation as adjunctive therapy in juvenile idiopathic arthritis: a randomized-controlled pilot study.
    Elsherif N; Shousha G; Sabri NA; Shawki MA · Immunopharmacology and immunotoxicology · 2026
    Randomized trial58 participantsAnti-Inflammatory Support forCoenzyme Q-10
  32. Resveratrol decreases local inflammatory markers and systemic endotoxin in patients with aggressive periodontitis.
    Zhang Q; Xu S; Xu W; Zhou Y; Luan H; Wang D · Medicine · 2022
    Randomized trial160 participantsAnti-Inflammatory Support forResveratrol
  33. Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial.
    Keramatzadeh S; Hosseini SA; Majdinasab N; Cheraghian B; Zilaee M · Nutritional neuroscience · 2025
    Randomized trial55 participantsAnti-Inflammatory Support forResveratrol
  34. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease.
    Tomé-Carneiro J; Gonzálvez M; Larrosa M; Yáñez-Gascón MJ; García-Almagro FJ; Ruiz-Ros JA; García-Conesa MT; Tomás-Barberán FA; Espín JC · The American journal of cardiology · 2012
    Randomized trial75 participantsAnti-Inflammatory Support forResveratrol
  35. Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials.
    Guo XF; Li JM; Tang J; Li D · Critical reviews in food science and nutrition · 2019
    Meta-analysis1,069 participants29 studies pooledAnti-Inflammatory Support forResveratrol
  36. Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial.
    Rae C; Digney AL; McEwan SR; Bates TC · Proceedings. Biological sciences · 2003
    Randomized trial45 participantsBrain Health forCreatine
  37. Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.
    Hersch SM; Gevorkian S; Marder K; Moskowitz C; Feigin A; Cox M; Como P; Zimmerman C; Lin M; Zhang L; Ulug AM; Beal MF; Matson W; Bogdanov M; Ebbel E; Zaleta A; Kaneko Y; Jenkins B; Hevelone N; Zhang H; Yu H; Schoenfeld D; Ferrante R; Rosas HD · Neurology · 2006
    Randomized trial64 participantsBrain Health forCreatine
  38. Creatine supplementation and cognitive performance in elderly individuals.
    McMorris T; Mielcarz G; Harris RC; Swain JP; Howard A · Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2008
    Randomized trial32 participantsBrain Health Productivity Boost forCreatine
  39. Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.
    Fernandez-Garrido J; Martin EG; Saez-Berlanga A; Gargallo-Bayo P; Gene-Morales J; Alix-Fages C; Jiménez-Martínez P; Caballero O; Salvador-Palmer R; Colado JC · Experimental gerontology · 2026
    Randomized trial103 participantsBrain Health General Health forCreatine
  40. Single-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
    Gordji-Nejad A; Matusch A; Hengstler L; Beer S; Kroll T; Klein S; Elmenhorst D; Bauer A; Drzezga A · Nutrients · 2026
    Randomized trial29 participantsBrain Health forCreatine
  41. Can thiamine substitution restore cognitive function in alcohol use disorder?
    Listabarth S; Vyssoki B; Marculescu R; Gleiss A; Groemer M; Trojer A; Harrer C; Weber S; König D · Alcohol and alcoholism (Oxford, Oxfordshire) · 2023
    Clinical trial50 participantsBrain Health forThiamin
  42. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.
    Galvin R; Bråthen G; Ivashynka A; Hillbom M; Tanasescu R; Leone MA; EFNS · European journal of neurology · 2011
    Guideline / consensusBrain Health forThiamin
  43. Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review.
    Cantu-Weinstein A; Branning R; Alamir M; Weleff J; Do M; Nero N; Anand A · General hospital psychiatry · 2024
    Systematic review688 participants27 studies pooledBrain Health forThiamin
  44. Vitamin Supplementation and Dementia: A Systematic Review.
    Gil Martínez V; Avedillo Salas A; Santander Ballestín S · Nutrients · 2022
    Systematic reviewBrain Health forThiamin
  45. Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.
    Jia W; Wang H; Li C; Shi J; Yong F; Jia H · Journal of translational medicine · 2024
    Cross-sectional study2,422 participantsBrain Health forThiamin
  46. Relationship between vitamin B12 levels and motor development: A systematic review.
    Dos Santos MERA; da Silva KG; da Silva Souza AP; da Silva ABJ; da Silva RF; da Silva EHA; de Souza SL; Barros WMA · Clinical nutrition ESPEN · 2024
    Systematic review1,559 participants8 studies pooledBrain Health forVitamin B12
  47. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsBrain Health forVitamin B12
  48. Structural and Functional Brain Changes Associated with Vitamin B12 Deficiency using Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
    Alghamdi A · Current medical imaging · 2023
    Meta-analysis12 studies pooledBrain Health forVitamin B12
  49. Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.
    Franco L; de Andrade CVF; Margini LV; Sousa N · Frontiers in neuroscience · 2026
    Systematic review22 studies pooledBrain Health forVitamin B12
  50. Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline.
    Marino FR; Rogers G; Miller JW; Selhub J; Mez J; Crane PK; Mukherjee S; Saykin AJ; Hohman TJ; Trittschuh EH; Au R; Jacques PF; Hwang PH · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Cohort study1,994 participantsBrain Health forVitamin B12
  51. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
    Liu Z; Tian Z; Zhao D; Liang Y; Dai S; Liu M; Hou S; Dong X; Zhaxinima; Yang Y · The Journal of clinical endocrinology and metabolism · 2022
    Meta-analysis2,794 participants50 studies pooledCardiovascular Support Heart Health forCoenzyme Q-10
  52. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
    Vrentzos E; Ikonomidis I; Pavlidis G; Katogiannis K; Korakas E; Kountouri A; Pliouta L; Michalopoulou E; Pelekanou E; Boumpas D; Lambadiari V · Cardiovascular diabetology · 2024
    Randomized trial60 participantsCardiovascular Support forCoenzyme Q-10
  53. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
    Mortensen SA; Rosenfeldt F; Kumar A; Dolliner P; Filipiak KJ; Pella D; Alehagen U; Steurer G; Littarru GP; Q-SYMBIO Study Investigators · JACC. Heart failure · 2015
    Randomized trial420 participantsCardiovascular Support forCoenzyme Q-10
  54. [Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
    Mareev VY; Mareev YV; Begrambekova YL · Kardiologiia · 2022
    Meta-analysis1,139 participants6 studies pooledCardiovascular Support forCoenzyme Q-10
  55. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
    Mortensen AL; Rosenfeldt F; Filipiak KJ · Cardiology journal · 2020
    Randomized trialCardiovascular Support forCoenzyme Q-10
  56. L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes.
    Malaguarnera M; Vacante M; Avitabile T; Malaguarnera M; Cammalleri L; Motta M · The American journal of clinical nutrition · 2009
    Randomized trial81 participantsCardiovascular Support Heart Health forL-Carnitine
  57. L-Carnitine's Effect on the Biomarkers of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Choi M; Park S; Lee M · Nutrients · 2021
    Meta-analysis9 studies pooledCardiovascular Support Heart Health forL-Carnitine
  58. The Effects of L-Carnitine on Echocardiographic Changes in Patients With β-Thalassemia Major and Intermedia.
    Shahidi M; Hashemi SR; Fattahi N; Roshani D; Vahedi S; Sharifi P; Moradveisi B · Journal of pediatric hematology/oncology · 2020
    Randomized trial60 participantsCardiovascular Support forL-Carnitine
  59. Efficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus.
    Solfrizzi V; Capurso C; Colacicco AM; D'Introno A; Fontana C; Capurso SA; Torres F; Gadaleta AM; Koverech A; Capurso A; Panza F · Atherosclerosis · 2007
    Randomized trial52 participantsCardiovascular Support forL-Carnitine
  60. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  61. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  62. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  63. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  64. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  65. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial.
    Tomé-Carneiro J; Gonzálvez M; Larrosa M; García-Almagro FJ; Avilés-Plaza F; Parra S; Yáñez-Gascón MJ; Ruiz-Ros JA; García-Conesa MT; Tomás-Barberán FA; Espín JC · Molecular nutrition & food research · 2012
    Randomized trial75 participantsCardiovascular Support forResveratrol
  66. Resveratrol improves lipid profile and recovers heart function in postoperative CABG patients.
    Ahmadi P; Akbarzadeh S; Alizadeh M; Mohammadi N; Mahmoodi M; Amini A; Netticadan T; Rezaei M; Movahed A · Molecular and cellular biochemistry · 2025
    Randomized trial60 participantsCardiovascular Support forResveratrol
  67. Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases.
    Shen CY; Li CP; Yu JT; Ho YJ; Tsai RY · In vivo (Athens, Greece) · 2026
    Meta-analysis2,551 participants40 studies pooledCardiovascular Support forResveratrol
  68. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults.
    Wong RH; Berry NM; Coates AM; Buckley JD; Bryan J; Kunz I; Howe PR · Journal of hypertension · 2014
    Randomized trial28 participantsCardiovascular Support forResveratrol
  69. Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial.
    Simental-Mendía LE; Guerrero-Romero F · Nutrition (Burbank, Los Angeles County, Calif.) · 2020
    Randomized trial71 participantsCardiovascular Support forResveratrol
  70. Effects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
    Ben Maaoui K; Delleli S; Mahdi N; Jebabli A; Del Coso J; Chtourou H; Ardigò LP; Ouergui I · Nutrients · 2025
    Randomized trial14 participantsCognitive Support forCreatine
  71. Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation.
    Turner CE; Byblow WD; Gant N · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Randomized trial15 participantsCognitive Support Productivity Boost forCreatine
  72. The effects of creatine supplementation on cognitive performance-a randomised controlled study.
    Sandkühler JF; Kersting X; Faust A; Königs EK; Altman G; Ettinger U; Lux S; Philipsen A; Müller H; Brauner J · BMC medicine · 2023
    Randomized trial123 participantsCognitive Support Productivity Boost forCreatine
  73. Acute creatine supplementation enhances technical performance in adolescent basketball players under cognitive-motor dual-task condition.
    Wu J; Qiu P; Li Y · Journal of the International Society of Sports Nutrition · 2025
    Randomized trial40 participantsCognitive Support forCreatine
  74. Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials.
    Prokopidis K; Giannos P; Triantafyllidis KK; Kechagias KS; Forbes SC; Candow DG · Nutrition reviews · 2023
    Meta-analysis225 participants10 studies pooledCognitive Support forCreatine
  75. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  76. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  77. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  78. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  79. Synergistic effects of creatine, carbs, protein on repeated sprint performance.
    Wang Y; Wei H; Cheng X; Chen Z · Scientific reports · 2026
    Randomized trial60 participantsEnergy forCreatine
  80. The Effects of Creatine Monohydrate Supplementation on Recovery from Eccentric Exercise-Induced Muscle Damage: A Double-Blind, Randomized, Placebo-Controlled Trial Considering Sex and Age Differences.
    Yamaguchi S; Inami T; Nishioka T; Morito A; Ishiyama K; Murayama M · Nutrients · 2025
    Randomized trial40 participantsEnergy forCreatine
  81. The Effect of Prior Creatine Intake for 28 Days on Accelerated Recovery from Exercise-Induced Muscle Damage: A Double-Blind, Randomized, Placebo-Controlled Trial.
    Yamaguchi S; Inami T; Ishida H; Morito A; Yamada S; Nagata N; Murayama M · Nutrients · 2024
    Randomized trial20 participantsEnergy forCreatine
  82. Creatine supplementation attenuates the rate of fatigue development during intermittent isometric exercise performed above end-test torque.
    Abdalla LHP; Broxterman RM; Greco CC; Denadai BS · Experimental physiology · 2021
    Randomized trial16 participantsEnergy forCreatine
  83. The effect of continuous low dose creatine supplementation on force, power, and total work.
    Burke DG; Silver S; Holt LE; Smith Palmer T; Culligan CJ; Chilibeck PD · International journal of sport nutrition and exercise metabolism · 2000
    Randomized trial41 participantsEnergy forCreatine
  84. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  85. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  86. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  87. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  88. Dietary reference values for thiamin.
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    Guideline / consensusEnergy forThiamin
  89. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  90. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  91. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  92. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  93. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  94. The impact of creatine supplementation associated with resistance training on muscular strength and lean tissue mass in the aged: a systematic review and meta-analysis.
    Liu S; Huang N; Wu W; OuYang X; Luo Y; Zhong Y; Wang M; Xiao L · European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026
    Meta-analysis482 participants8 studies pooledGeneral Health forCreatine
  95. Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease.
    Fuld JP; Kilduff LP; Neder JA; Pitsiladis Y; Lean ME; Ward SA; Cotton MM · Thorax · 2005
    Randomized trial38 participantsGeneral Health forCreatine
  96. A multi-metabolite signature robustly predicts long-term mortality in the PREDIMED trial and several US cohorts.
    Fernández-Duval G; Razquin C; Wang F; Yun H; Hu J; Guasch-Ferré M; Rexrode K; Balasubramanian R; García-Gavilán J; Ruiz-Canela M; Clish CB; Corella D; Gómez-Gracia E; Fiol M; Estruch R; Lapetra J; Fitó M; Serra-Majem L; Ros E; Liang L; Dennis C; Asensio EM; Castañer O; Planes FJ; Salas-Salvadó J; Hu FB; Toledo E; Martínez-González MA · Metabolism: clinical and experimental · 2025
    Cohort study1,878 participantsGeneral Health forCreatine
  97. Plasma creatine, estimated intramuscular creatine, transcellular gradient and the risk of mortality: Results from the PREVEND study.
    Doorenbos CSE; Post A; Stegmann ME; Franssen CFM; Dullaart RPF; Navis G; Connelly MA; Bakker SJL · European journal of clinical investigation · 2026
    Cohort study5,127 participantsGeneral Health forCreatine
  98. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  99. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  100. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  101. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  102. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  103. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial.
    Sabbatinelli J; Orlando P; Galeazzi R; Silvestri S; Cirilli I; Marcheggiani F; Dludla PV; Giuliani A; Bonfigli AR; Mazzanti L; Olivieri F; Antonicelli R; Tiano L · Nutrients · 2021
    Randomized trial51 participantsHeart Health forCoenzyme Q-10
  104. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Zhao D; Liang Y; Dai S; Hou S; Liu Z; Liu M; Dong X; Zhan Y; Tian Z; Yang Y · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis1,831 participants26 studies pooledHeart Health forCoenzyme Q-10
  105. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledHeart Health Metabolism Boost forCoenzyme Q-10
  106. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.
    Zhang P; Yang C; Guo H; Wang J; Lin S; Li H; Yang Y; Ling W · Journal of clinical lipidology · 2019
    Randomized trial101 participantsHeart Health forCoenzyme Q-10
  107. Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial.
    Iliceto S; Scrutinio D; Bruzzi P; D'Ambrosio G; Boni L; Di Biase M; Biasco G; Hugenholtz PG; Rizzon P · Journal of the American College of Cardiology · 1995
    Randomized trial472 participantsHeart Health forL-Carnitine
  108. The effect of L-carnitine supplementation on lipid profile in adults: an umbrella meta-analysis on interventional meta-analyses.
    Musazadeh V; Alinejad H; Esfahani NK; Kavyani Z; Keramati M; Roshanravan N; Mosharkesh E; Dehghan P · Frontiers in nutrition · 2023
    Meta-analysis13 studies pooledHeart Health forL-Carnitine
  109. The effects of L-carnitine supplementation on cardiovascular risk factors in participants with impaired glucose tolerance and diabetes: a systematic review and dose-response meta-analysis.
    Gheysari R; Nikbaf-Shandiz M; Hosseini AM; Rasaei N; Hosseini S; Bahari H; Asbaghi O; Rastgoo S; Goudarzi K; Shiraseb F; Behmadi R · Diabetology & metabolic syndrome · 2024
    Meta-analysis2,900 participants21 studies pooledHeart Health forL-Carnitine
  110. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  111. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  112. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  113. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  114. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsHeart Health forVitamin B12
  115. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  116. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  117. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  118. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.
    Zhang P; Chen K; He T; Guo H; Chen X · Nutrition & metabolism · 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  119. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forCoenzyme Q-10
  120. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ · Food & function · 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  121. The effect of coenzyme Q10 intake on metabolic profiles in women candidates for in-vitro fertilization: a randomised trial.
    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M · Annals of medicine and surgery (2012) · 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10
  122. Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression.
    Kondo DG; Forrest LN; Shi X; Sung YH; Hellem TL; Huber RS; Renshaw PF · Amino acids · 2017
    Randomized trialMetabolism Boost forCreatine
  123. Creatine supplementation and glycemic control: a systematic review.
    Pinto CL; Botelho PB; Pimentel GD; Campos-Ferraz PL; Mota JF · Amino acids · 2017
    Systematic reviewMetabolism Boost forCreatine
  124. The effect of dietary creatine supplementation on skeletal muscle metabolism in congestive heart failure.
    Andrews R; Greenhaff P; Curtis S; Perry A; Cowley AJ · European heart journal · 1998
    Clinical trialMetabolism Boost forCreatine
  125. A comprehensive review of the physiology and evidence base to guide the use of ergogenic and medical supplements for enhanced cycling performance.
    Rowland A; Edwards S; Prieto-Bellver G; Menz B; Rowland A; Cornelisse E; Karapetis CS; Wallen MP; Hopkins AM · Journal of the International Society of Sports Nutrition · 2026
    Narrative reviewMetabolism Boost forCreatine
  126. Creatine Supplementation Beyond Athletics: Benefits of Different Types of Creatine for Women, Vegans, and Clinical Populations-A Narrative Review.
    Gutiérrez-Hellín J; Del Coso J; Franco-Andrés A; Gamonales JM; Espada MC; González-García J; López-Moreno M; Varillas-Delgado D · Nutrients · 2025
    Narrative reviewMetabolism Boost forCreatine
  127. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis.
    Zhu X; Wu C; Qiu S; Yuan X; Li L · Nutrition & metabolism · 2022
    Meta-analysis283 participants9 studies pooledMetabolism Boost forResveratrol
  128. Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.
    Sun JN; Yang R; Fang L; Li YJ; Xing WY; Sun ML; Wu L; Wu QJ; Gong TT · Nutrition journal · 2026
    Meta-analysis45 studies pooledMetabolism Boost forResveratrol
  129. Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial.
    Chen S; Zhao X; Ran L; Wan J; Wang X; Qin Y; Shu F; Gao Y; Yuan L; Zhang Q; Mi M · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2015
    Randomized trial60 participantsMetabolism Boost forResveratrol
  130. Supplementation with resveratrol modified gut microbiota improving insulin sensitivity and lipid metabolism in subjects with obesity and insulin resistance.
    Guevara-Cruz M; Sánchez-Tapia M; Velazquez-Villegas LA; Torre-Villalvazo I; Guizar-Heredia R; Godínez-Salas E; López-Barradas A; Granados O; Torres-Villalobos G; Torres N; Tovar AR · European journal of nutrition · 2026
    Randomized trial32 participantsMetabolism Boost forResveratrol
  131. Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review.
    Zhou Q; Wang Y; Han X; Fu S; Zhu C; Chen Q · Frontiers in physiology · 2022
    Meta-analysis1,171 participants25 studies pooledMetabolism Boost forResveratrol
  132. Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation.
    Gordji-Nejad A; Matusch A; Kleedörfer S; Jayeshkumar Patel H; Drzezga A; Elmenhorst D; Binkofski F; Bauer A · Scientific reports · 2024
    Randomized trialProductivity Boost forCreatine
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    Hammett ST; Wall MB; Edwards TC; Smith AT · Neuroscience letters · 2010
    Non-randomized trialProductivity Boost forCreatine
  134. Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.
    Tao MH; Chuang SC; Wu IC; Chan HT; Cheng CW; Chen HL; Lee MM; Chang HY; Hsiung CA; Hsu CC · European journal of nutrition · 2024
    Cohort study5,663 participantsProductivity Boost forMagnesium
  135. Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.
    Tu X; Qiu H; Lin S; He W; Huang G; Zhang X; Wu Y; He J · Neuropsychiatric disease and treatment · 2022
    Cohort study327 participantsProductivity Boost forMagnesium
  136. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
    Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
    Randomized trial100 participantsProductivity Boost forMagnesium
  137. Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
    Lai XN; Sadhwani V; Ng WM; Gani A · Cureus · 2025
    Cohort study667 participantsProductivity Boost forMagnesium
  138. Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.
    Chen M; Xue R; Zhang M; Zhang J; Zheng J; Ye D; Sun J · Journal of the American Medical Directors Association · 2025
    Cross-sectional study2,768 participantsProductivity Boost forMagnesium
  139. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
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  141. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
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    Clinical trialSkin Health forResveratrol
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