Product Image

Ultra B-100 Complex

Mason Natural
4.8
★ ★ ★ ★ ★
(114 ratings)
Thiamin 100 mg
Riboflavin 100 mg
Vitamin B5 100 mg
Vitamin B6 100 mg
Vitamin B12 100 mcg
Product Image
Score63
Broad and inexpensive high-potency coverage comes with an excessive B6 amount and mixed ingredient quality.
How scoring works
Quantity:100 Tablet(s) • (100 servings)
Goals:
Heart Health
Energy
Metabolism Boost

Score 63

Broad and inexpensive high-potency coverage comes with an excessive B6 amount and mixed ingredient quality.
How scoring works
$11.84($0.11 per serving)
iHerb
$ 11.84
Vitacost
$ 12.05
Report prices

Analysis

Large amounts of thiamine, riboflavin, niacinamide, pyridoxine, and pantothenic acid create broad high-potency coverage. Folate, B12, biotin, and a food base add breadth, but several minor amounts appear too small to matter.

The 100 mg vitamin B6 dose is the main weakness because prolonged use may contribute to peripheral nerve symptoms. Cyanocobalamin and standard riboflavin also provide less form quality than active alternatives.

The tablet is inexpensive for the listed amounts and suits users specifically seeking a high-potency complex. It is poorly suited to indefinite daily use without a clear reason for these doses.

Who is it for
  • Adults seeking a short-term high-potency B-complex
  • Users prioritizing dose over active forms
  • People working with a clinician on targeted intake
Best for
  • High-potency thiamine
  • Broad B-vitamin coverage
  • Low-cost short-term use

Pros

  • Wide nutrient range
  • High thiamine and riboflavin amounts
  • Low serving cost

Cons

  • Contains 100 mg pyridoxine
  • Uses cyanocobalamin
  • Some supporting ingredients are present only in trace amounts

Warnings

  • Long-term use of 100 mg vitamin B6 may cause numbness, tingling, or balance problems
  • Do not stack with other B6 supplements
  • The 100 mg niacinamide amount may cause nausea or digestive discomfort

Nutrient quality

53 Moderate impact

Pyridoxine, folic acid or unspecified folate, and cyanocobalamin are conventional rather than metabolically direct forms. Several vitamins are supplied at very high amounts while choline and other additions are comparatively weak.

.

Ingredient transparency

73 High impact

Every listed active has a specific amount. A complete excipient list is not available in the supplied data.

.

Customer satisfaction

70 High impact

The average rating is very strong. The modest rating volume limits confidence.

.

Value for money

54 Moderate impact

The supply provides reasonable value per effective serving. Weak or opaque additions reduce practical value.

.
Report analysis

Goals

Heart Health
Heart Health
Impact
High effect
C+ Goal FitB- Strength of SupportC CoverageB+ Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 667 mcg DFE

Vitamin B6, folate, and vitamin B12 form a relevant combination for homocysteine metabolism. The formula uses ordinary pyridoxine and cyanocobalamin rather than preferred active forms.

Niacinamide supports basic nutrition but is not the form used for targeted lipid management. The high vitamin B6 amount reaches a chronic-use safety boundary and may raise neuropathy risk with prolonged daily use.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Energy
Essential Energy Nutrients
Energy
Impact
High effect
B+ Goal FitC Strength of SupportC CoverageC Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

A full B-complex supports many steps in energy-yielding metabolism, with several high-potency amounts. Thiamine, riboflavin, niacin, vitamin B6, and pantothenic acid all contribute to cellular fuel use.

Vitamin B12 is below the preferred energy threshold and uses cyanocobalamin, while the vitamin B6 amount is unusually high for daily use. Sustained intake of that B6 amount may raise the risk of nerve symptoms, and the vague food blend adds little evaluable value.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
Metabolism Boost
Metabolic B-Vitamins
Metabolism Boost
Impact
High effect
C- Goal FitC+ Strength of SupportC CoverageB Formula Quality
Biotin · 100 mcgNiacin · 100 mg NEVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

High-dose B vitamins support the enzyme systems that convert food into cellular energy, but they do not directly raise calorie expenditure in adequately nourished users. The formula is therefore better suited to correcting nutrient gaps than producing a noticeable metabolic boost.

Several amounts are substantial, yet most forms are conventional and the vitamin B6 amount reaches a chronic-use safety concern. Daily intake of 100 mg vitamin B6 may raise peripheral neuropathy risk when used for a long period.

Study evidence
Riboflavin Mixed 5 studies
Thiamin Supportive 11 studies
Vitamin B12 Supportive 10 studies
Vitamin B6 Supportive 16 studies
General Health
Daily Energy Vitality
General Health
Impact
Moderate effect
A- Goal FitD Strength of SupportC CoverageC Formula Quality
Folate · 667 mcg DFEVitamin B12 · 100 mcg

A broad B-complex supports normal energy metabolism, nerve function, and red blood cell formation. The nutrient roles are well established, but several very large amounts reduce its fit for routine everyday use.

Cyanocobalamin and conventional B6 limit form quality, while tiny accessory nutrients and an undefined food base add little clarity. The formula is better suited to deliberate high-potency B-vitamin use than balanced general nutrition.

Study evidence
Vitamin B12 Adverse 66 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
C- Goal FitC- Strength of SupportD CoverageC+ Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 667 mcg DFENiacin · 100 mg NE

Folate, B6, and B12 support homocysteine metabolism, but the product is a general high-potency B complex. No lipid, endothelial, cardiac-energy, or rhythm-supporting active broadens the design.

Cyanocobalamin, pyridoxine, and unspecified folate limit form quality. Long-term daily use of the very high vitamin B6 amount may cause peripheral neuropathy.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies

Ingredients

IngredientAmount per serving
Vitamin B1 (Thiamine Hydrochloride)
 100 mg
Vitamin B2 (Riboflavin)
 100 mg
Niacin (Niacinamide)
 100 mg NE
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Folate
667 mcg DFE
Vitamin B12 (Cyanocobalamin)
 100 mcg
Biotin
100 mcg
Pantothenic Acid (Calcium Pantothenate)
 100 mg
Choline (Choline Bitartrate)
 100 mcg
Calcium (Calcium Phosphate)
 77 mg
Inositol
100 mcg
Para-Aminobenzoic Acid
100 mcg
Natural Food Base
100 mg
Gluten Free Adults 18–50
Report overview
Thiamin (Thiamine Hydrochloride) · 100 mg OverallScore88
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Thiamine hydrochloride provides a standard water-soluble source, and the 100 mg amount reaches a high-potency range for targeted use. The conventional tablet lacks enough excipient detail to confirm a cleaner delivery system. The high dose and low serving cost create strong value within a B-complex.

View ingredientView products
Riboflavin · 100 mg OverallScore74
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Standard riboflavin requires conversion before it can support energy metabolism. The 100 mg dose provides high-potency metabolic support. The low serving cost and high-potency dose provide excellent value.

View ingredientView products
Vitamin B5 (Calcium Pantothenate) · 100 mg OverallScore72
A Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Calcium pantothenate is a stable, well-absorbed standard form of vitamin B5. The 100 mg dose provides solid general maintenance and metabolic support. Cost per equivalent 500 mg amount is slightly above the favorable range for a standard form.

View ingredientView products
Loading alternative details
85 Performance

B-Complex Plus

Pure Encapsulations
<p>Methylfolate, methylcobalamin, P-5-P, and activated riboflavin create a focused, well-balanced B-complex. Elevated niacin still deserves attention, but the restrained vitamin B6 amount and large package support strong routine value. Compared with the original, the disclosed formula provides a more convincing match for Vitamin B12, Thiamin, Vitamin B6, and Riboflavin and General Health, Energy, and Heart Health without making cost the deciding factor.</p>
81 Performance

Activated B-Complex High Bioavailability

Swanson
<p>Active B-vitamin forms, benfotiamine, and pantethine create a high-quality, focused formula at a reasonable cost. Vitamin B6 remains high for long-term use, while choline and biotin are modest. Compared with the original, the disclosed formula provides a more convincing match for Vitamin B12, Thiamin, Vitamin B6, and Riboflavin and General Health, Energy, and Heart Health without making cost the deciding factor.</p>
80 Performance

B-Complex #12

Thorne
<p>A focused one-capsule B-complex with methylcobalamin provides substantial nutritional support for normal energy metabolism. Several forms are not identified, and the vitamin B6 and niacin amounts warrant attention when other fortified products are also used. Compared with the original, the disclosed formula provides a more convincing match for Vitamin B12, Thiamin, Vitamin B6, and Riboflavin and General Health, Energy, and Heart Health without making cost the deciding factor.</p>
67 Budget

B 100 Complex

Spring Valley
<p>A very inexpensive tablet supplies a broad set of B vitamins at substantial amounts. Missing chemical forms and excessive vitamin B6 prevent a confident quality or routine-safety assessment. Compared with the original, its lower serving cost improves affordability while retaining coverage for Vitamin B12, Thiamin, Vitamin B6, and Riboflavin and General Health, Energy, and Heart Health.</p>
80 Budget

B-Complex '100'

Solgar
<p>A broad high-potency B-vitamin profile supports normal energy metabolism, but most forms are conventional and several amounts greatly exceed routine needs. The vitamin B6 serving reaches the chronic-use safety ceiling and may cause nerve damage with prolonged use, making unsupervised daily supplementation a poor fit. The supplied candidate pool does not contain three strictly cheaper choices; this is one of the closest-cost eligible options and retains coverage for Vitamin B12, Thiamin, Vitamin B6, and Riboflavin and General Health, Energy, and Heart Health.</p>
80 Budget

B-100 Complex with B2 Coenzyme

Nature's Way
<p>Active riboflavin and partial P-5-P improve this otherwise conventional high-potency B-complex. The total vitamin B6 amount reaches the chronic-use safety ceiling and may cause tingling, numbness, or other nerve symptoms with prolonged use. The supplied candidate pool does not contain three strictly cheaper choices; this is one of the closest-cost eligible options and retains coverage for Vitamin B12, Thiamin, Vitamin B6, and Riboflavin and General Health, Energy, and Heart Health.</p>
79 Value

B-100 Complex

21st Century
<p>A broad high-potency B-vitamin profile supports normal energy metabolism, but most forms are conventional and several amounts greatly exceed routine needs. The vitamin B6 serving reaches the chronic-use safety ceiling and may cause nerve damage with prolonged use, making unsupervised daily supplementation a poor fit. Compared with the original, the combination of Vitamin B12, Thiamin, Vitamin B6, and Riboflavin coverage, General Health, Energy, and Heart Health alignment, and serving cost offers a better balance of formulation and value.</p>
74 Value

BioActive Complete B-Complex

Life Extension
<p>Active B-vitamin forms and complete coverage come at a very low serving cost. Extremely high vitamin B6, niacin, and pantothenic acid amounts make the formula unnecessarily aggressive for routine use. Compared with the original, the combination of Vitamin B12, Thiamin, Vitamin B6, and Riboflavin coverage, General Health, Energy, and Heart Health alignment, and serving cost offers a better balance of formulation and value.</p>
83 Value

Multi-B Benfotiamine 150 mg

BenfoComplete.com
<p>Benfotiamine and methylcobalamin add strong form quality to a practical B-vitamin blend. Folic acid and pyridoxine are less favorable choices, but sensible amounts and a long supply support good value. Compared with the original, the combination of Vitamin B12, Thiamin, Riboflavin, and Vitamin B5 coverage, General Health, Energy, and Hair Health alignment, and serving cost offers a better balance of formulation and value.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  2. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  3. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  4. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  5. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  6. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  7. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  8. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  9. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  10. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  11. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  12. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  13. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  14. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  15. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  16. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  17. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  18. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  19. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  20. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  21. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  22. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  23. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  24. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  25. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  26. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  27. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  28. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  29. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  30. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  31. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  32. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  33. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  34. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  35. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  36. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  37. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  38. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  39. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  40. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  41. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  42. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  43. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  44. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  45. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  46. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  47. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  48. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  49. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  50. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  51. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  52. Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults.
    Dhir S; Tarasenko M; Napoli E; Giulivi C · Frontiers in psychiatry · 2026
    Narrative reviewMetabolism Boost forThiamin
  53. Plasma vitamin profiles and their associations with metabolic health and mental wellbeing in midlife Asian women.
    Tan KML; Tint MT; Cabral RM; Lau R; Kee MZL; Garg V; De Iorio M; Tan SSL; Eriksson JG · Scientific reports · 2026
    Cohort study662 participantsMetabolism Boost forThiamin
  54. High-resolution plasma metabolomics and thiamine status in critically Ill adult patients.
    Gundogan K; Nellis MM; Ozer NT; Ergul SS; Sahin GG; Temel S; Yuksel RC; Teeny S; Alvarez JA; Sungur M; Jones DP; Ziegler TR · Metabolomics : Official journal of the Metabolomic Society · 2024
    Cross-sectional study76 participantsMetabolism Boost forThiamin
  55. Pathophysiology, prevention, and treatment of beriberi after gastric surgery.
    Wilson RB · Nutrition reviews · 2021
    Narrative reviewMetabolism Boost forThiamin
  56. Red blood cell transketolase activity and the effect of thiamine supplementation in patients with chronic liver disease.
    Rossouw JE; Labadarios D; Krasner N; Davis M; Williams R · Scandinavian journal of gastroenterology · 1978
    Single-arm trialMetabolism Boost forThiamin
  57. Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study).
    Saravanan P; Sukumar N; Adaikalakoteswari A; Goljan I; Venkataraman H; Gopinath A; Bagias C; Yajnik CS; Stallard N; Ghebremichael-Weldeselassie Y; Fall CHD · Diabetologia · 2022
    Cohort study4,746 participantsMetabolism Boost forVitamin B12
  58. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
    Olivieri G; Bordugo A; Burnyte B; Costetti A; Couce ML; Diogo L; Feillet F; Froese DS; Greco B; Gueant JL; Hannibal L; Hörster F; Kožich V; La Marca G; Manoli I; Mochel F; Orazi L; Pérez B; Schiff M; Schwahn BC; Schwartz I; Stepien KM; Sykut-Cegielska J; Tangeraas T; Zetterström RH; Dionisi-Vici C; Huemer M · Journal of inherited metabolic disease · 2026
    Guideline / consensusMetabolism Boost forVitamin B12
  59. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
    Carmel R; Melnyk S; James SJ · Blood · 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  60. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D · Frontiers in pharmacology · 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
  61. Diagnosis and treatment of vitamin B12 deficiency in children.
    Kanvinde P; Khurana R; Mudaliar S · Frontiers in nutrition · 2026
    Narrative reviewMetabolism Boost forVitamin B12
  62. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  63. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  64. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  65. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  66. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6