Product Image

B-100 Gels

Carlson
4.8
★ ★ ★ ★ ★
(266 ratings)
Thiamin 100 mg
Niacin 100 mg
Vitamin B5 100 mg
Riboflavin 100 mg
Vitamin B6 100 mg
Vitamin B12 100 mcg
Product Image
Score71

A broad B-100 softgel with phosphatidylcholine but very high vitamin B6 and folate. It needs a more deliberate use plan than a moderate daily B complex.

How scoring works
Quantity:100 Softgel(s) • (50 servings)
Goals:
Energy
General Health
Heart Health
Metabolism Boost

Score 71

A broad B-100 softgel with phosphatidylcholine but very high vitamin B6 and folate. It needs a more deliberate use plan than a moderate daily B complex.

How scoring works

Also available as

3 options
50 mg • 200 Softgel(s) servings 50 mg • 200 Softgel(s) • 200 servings $48.37 ($0.24 per serving) 50 mg • 50 Softgel(s) servings 50 mg • 50 Softgel(s) • 50 servings $14.37 ($0.28 per serving) 200 servings 2 Softgel(s) • 200 Softgel(s) • 100 servings $43.52 ($0.43 per serving)
$23.38($0.46 per serving)
iHerb
$ 0.00
Vitacost
$ 23.38
Pure Formulas
$ 23.38
iHerb
$ 23.38
Report prices

Analysis

The serving supplies 100 mg each of thiamine, riboflavin, niacinamide, vitamin B6, and pantothenic acid. It also includes 1,360 mcg DFE folate, cyanocobalamin, biotin, and phosphatidylcholine from soybeans.

Softgel delivery adds 1.5 grams of fat and requires two units per serving. Conventional forms limit differentiation, while the vitamin B6 and folate amounts are aggressive for routine use.

The formula suits people who specifically prefer softgels and want phosphatidylcholine included. It is less compelling for casual daily use because dose fit and soy exposure require attention.

Who is it for
  • Adults who prefer softgels
  • People seeking a B complex with phosphatidylcholine
  • Users taking high-potency B vitamins under guidance
Best for
  • High-potency B-vitamin coverage
  • Normal energy metabolism
  • Phosphatidylcholine inclusion

Pros

  • Broad B-vitamin profile
  • Includes phosphatidylcholine
  • Clearly stated nutrient amounts
  • Softgel format

Cons

  • Requires two softgels
  • 100 mg vitamin B6 is very high
  • Folate amount is substantial
  • Mostly conventional forms

Warnings

  • Prolonged 100 mg vitamin B6 intake may cause nerve symptoms
  • The 1,360 mcg DFE folate amount may be inappropriate for some users without guidance
  • Contains soybean-derived phosphatidylcholine and may not suit people with soy allergy

Nutrient quality

65 High impact

The complete B-vitamin profile provides substantial metabolic cofactors in a focused formula. Conventional forms and an excessive vitamin B6 amount make the design less suitable for routine long-term use.

Ingredient transparency

84 Highest impact

The major B vitamins have separate amounts and no hidden blend obscures the core formula. Complete usage directions and the inactive-ingredient list are not supplied here.

Customer satisfaction

73 High impact

The exceptional average rating has a moderate review base. No review excerpts describe tolerance, effectiveness, or repeated complaints, so those experiences remain uncertain.

Value for money

59 Moderate impact

The softgel formula is relatively costly for conventional B-vitamin forms. A two-unit serving, added macronutrients, and excessive vitamin B6 make it less competitive than focused capsules.

Report analysis

Goals

Energy
Energy
Impact
High effect
B+ Goal FitB- Strength of SupportC CoverageA Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

A high-potency B-complex supplies the cofactors needed for carbohydrate, fat, and protein metabolism. Substantial thiamin, riboflavin, niacin, and pantothenic acid create focused support for cellular energy production.

Cyanocobalamin remains below the targeted B12 range for energy, and the formula does not address alertness or stress adaptation. The very high pyridoxine amount raises concern for prolonged daily use because excess vitamin B6 can affect nerves.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
General Health
Daily Energy Vitality
General Health
Impact
High effect
A- Goal FitC- Strength of SupportB- CoverageB Formula Quality
Folate · 1360 mcg DFEVitamin B12 · 100 mcg

The broad B-vitamin formula supports energy metabolism and helps cover several common nutritional gaps. Most ingredient amounts are clearly stated, but cyanocobalamin and pyridoxine are basic forms.

Vitamin B12 is present at a maintenance-oriented amount despite the otherwise high-potency formula. The 100 mg vitamin B6 amount is a meaningful long-term concern because sustained high intake can harm peripheral nerves.

Study evidence
Vitamin B12 Adverse 66 studies
Heart Health
Heart Health
Impact
High effect
C+ Goal FitB- Strength of SupportC CoverageB+ Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 1360 mcg DFE

Vitamin B6, folate, and vitamin B12 form a relevant combination for homocysteine metabolism. The formula uses ordinary pyridoxine and cyanocobalamin rather than preferred active forms.

Niacinamide supports basic nutrition but is not the form used for targeted lipid management. The high vitamin B6 amount reaches a chronic-use safety boundary and may raise neuropathy risk with prolonged daily use.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C Goal FitB- Strength of SupportC CoverageA- Formula Quality
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

The concentrated B-vitamin blend supplies broad cofactor support for cellular energy production. It may help when intake is inadequate, but it is not a direct thermogenic or fat-oxidation formula.

Most amounts are fully disclosed and substantial, while the vitamin forms are generally conventional. The pyridoxine amount is high for routine long-term use, which weakens the practical dose profile despite the formula's focus.

Study evidence
Vitamin B6 Supportive 16 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
D Goal FitC- Strength of SupportD CoverageC Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 1360 mcg DFENiacin · 100 mg

B vitamins support homocysteine metabolism and general energy pathways that can matter for cardiovascular health. The formula is not a targeted heart product because it lacks magnesium, omega-3 fats, CoQ10, or a nitric-oxide active.

Folate and B12 are present, but cyanocobalamin and conventional pyridoxine reduce form quality. The 100 mg vitamin B6 amount reaches a chronic-use ceiling and may raise the risk of sensory nerve symptoms with prolonged daily use.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Fat
1.5 Gram(s)
Protein
1 Gram(s)
Thiamine (Thiamine Mononitrate, Vitamin B1)
 100 mg
Riboflavin (Vitamin B2)
 100 mg
Niacin (Niacinamide)
 100 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Folate
1360 mcg DFE
Vitamin B12 (Cyanocobalamin)
 100 mcg
Biotin
100 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 100 mg
Phosphatidylcholine
13 mg
Phosphatidyl Choline (Soybeans)
 100 mg
Gluten Free Adults 18–50 Women
Report overview
Thiamin (Thiamine Mononitrate, Vitamin B1) · 100 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

A high-potency thiamin dose uses a standard water-soluble form rather than a premium form. The exact amount is clear, while the conventional softgel offers ordinary delivery quality. Cost per active amount is high for the thiamin supplied.

View ingredientView products
Niacin (Niacinamide) · 100 mg OverallScore74
B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyF Value

The B-complex supplies niacinamide at a substantial general-use amount. Its conventional softgel delivery has no special release feature, while the named form keeps classic flushing unlikely. The serving cost is relatively high for standard niacinamide despite the broader B-vitamin content.

View ingredientView products
Vitamin B5 (D-Calcium Pantothenate) · 100 mg OverallScore72
A Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

D-Calcium pantothenate is a stable, well-absorbed B5 form. The 100 mg dose supports general maintenance, and the source and amount are clearly stated. The two-softgel B-complex is costly relative to the active B5 delivered.

View ingredientView products
Loading alternative details
81 Performance

Fully Active B Complex with Quatrefolic

Doctor's Best
<p>Its label clearly provides 40 mg of Vitamin C as Ascorbic Acid, making it a more clearly defined vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5 option. Compared with the original, its ingredient and goal alignment is stronger, although the input does not provide independent testing or absorption evidence.</p>
78 Performance

Active B-Complex

Integrative Therapeutics
<p>Its label clearly provides 50 mg of Thiamine as Thiamine Hydrochloride, making it a more clearly defined vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5 option. Compared with the original, its ingredient and goal alignment is stronger, although the input does not provide independent testing or absorption evidence.</p>
80 Performance

Coenzyme B-Complex Caps

Country Life
<p>Its label clearly provides 50 mg of Thiamin as Thiamine Cocarboxylase Chloride, making it a more clearly defined vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5 option. Compared with the original, its ingredient and goal alignment is stronger, although the input does not provide independent testing or absorption evidence.</p>
80 Budget

B-Complex '100'

Solgar
<p>Its label clearly provides 100 mg of Thiamine as Thiamine Mononitrate, preserving relevant vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5 coverage. Compared with the original, it lowers the serving cost, although the input does not provide independent testing or absorption evidence.</p>
85 Budget

BioCoenzymated Active B Complex

Natural Factors
<p>Its label clearly provides 10 mg of Riboflavin as Riboflavin 5-Phosphate, preserving relevant vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5 coverage. Compared with the original, it lowers the serving cost, although the input does not provide independent testing or absorption evidence.</p>
73 Budget

B-50 Gels

Carlson
<p>Its label clearly provides 1 g of Total Fat, preserving relevant niacin and thiamin and vitamin b6 and riboflavin and vitamin b5 coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s vitamin b12 coverage.</p>
81 Value

Coenzyme B-Complex Caps

Country Life
<p>Its label clearly provides 50 mg of Thiamin as Thiamine Cocarboxylase Chloride, keeping the formula relevant to vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although the input does not provide independent testing or absorption evidence.</p>
85 Value

B-Complex Plus

Pure Encapsulations
<p>Its label clearly provides 100 mg of Thiamine as Thiamine Hydrochloride, keeping the formula relevant to vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although the input does not provide independent testing or absorption evidence.</p>
73 Value

B-50 Gels

Carlson
<p>Its label clearly provides 1 g of Total Fat, keeping the formula relevant to niacin and thiamin and vitamin b6 and riboflavin and vitamin b5. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s vitamin b12 coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  5. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  6. Vitamin B6 requirements of women using oral contraceptives.
    Leklem JE; Brown RR; Rose DP; Linkswiler HM · The American journal of clinical nutrition · 1975
    Non-randomized trial24 participantsMetabolism Boost forVitamin B6
  7. Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism.
    Whyte MP; Zhang F; Mack KE; Wenkert D; Gottesman GS; Ericson KL; Cole JT; Coburn SP · Bone · 2024
    Non-randomized trial149 participantsMetabolism Boost forVitamin B6
  8. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  9. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  10. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  11. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  12. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  13. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  14. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  15. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  16. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  17. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  18. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  19. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  20. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  21. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  22. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  23. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  24. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  25. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  26. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  27. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  28. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  29. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  30. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  31. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  32. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  33. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  34. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  35. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  36. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  37. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  38. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  39. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  40. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  41. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  42. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  43. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  44. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  45. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  46. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  47. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  48. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  49. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  50. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  51. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  52. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  53. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  54. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
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