Product Image

New Mood

Onnit
4.3
★ ★ ★ ★ ★
(8949 ratings)
Vitamin B6 20 mg
Tryptophan 400 mg
5-HTP 150 mg
Product Image
Score62
A concentrated tryptophan and 5-HTP mood-and-sleep blend. Serious serotonergic interaction risk and a proprietary blend sharply limit suitability.
How scoring works
Quantity:30 Capsule(s) • (15 servings)
Goals:
Mood Support
Sleep Support
Stress Relief

Score 62

A concentrated tryptophan and 5-HTP mood-and-sleep blend. Serious serotonergic interaction risk and a proprietary blend sharply limit suitability.
How scoring works

Also available as

1 option
60 servings B6 20 mg, B3 30 mg +2 more • 60 Capsule(s) • 30 servings $56.93 ($1.89 per serving)
$23.99($1.59 per serving)
Amazon
$ 29.95
iHerb
$ 29.95
iHerb
$ 29.95
Nutrition Faktory
$ 23.99
Report prices

Analysis

Potent 150 mg of 5-HTP and 400 mg of L-tryptophan provide a robust supply of materials for serotonin synthesis. This strategy is enhanced by the use of magnesium bisglycinate chelate for better absorption and physical relaxation.

A specialized tranquility blend featuring botanical extracts targets an overactive mind. Meaningful doses of B-vitamins are included to ensure the conversion pathways are properly supported.

Significant review count reflects high satisfaction with this comprehensive approach to mood and rest. While the investment per serving is higher, the complexity of the formula offers significant functional depth.

Who is it for
  • Adults using a professionally reviewed serotonin-support plan
  • People not taking serotonin-raising medicines
Best for
  • Short, carefully screened use
  • Users specifically directed to combine tryptophan and 5-HTP

Pros

  • Meaningful tryptophan amount
  • Meaningful 5-HTP amount
  • Includes vitamin D3
  • Uses magnesium bisglycinate

Cons

  • Tranquility blend hides component doses
  • Combines two serotonergic precursors
  • Magnesium amount is small
  • Only fifteen servings

Warnings

  • Do not combine 5-HTP and tryptophan with SSRIs, SNRIs, MAO inhibitors, tramadol, linezolid, or other serotonin-raising medicines because serotonin syndrome can occur.
  • Tryptophan and 5-HTP may cause sedation, so avoid driving or combining with alcohol or sedating products until effects are known.
  • Vitamin B6 at 20 mg should be counted with other B-complex supplements during prolonged use.

Nutrient quality

75 High impact

Tryptophan, 5-hydroxytryptophan, magnesium bisglycinate, and vitamin D provide coherent mood and sleep support. A hidden blend, a relatively high vitamin B6 amount, and overlapping serotonin precursors reduce balance and safety confidence.

Ingredient transparency

57 Moderate impact

The major serotonin precursors and several nutrients have stated amounts. A proprietary tranquility blend hides component doses, while duplicate vitamin D entries and missing non-active ingredients reduce clarity.

Customer satisfaction

67 High impact

The average rating is positive but less consistent despite a very large review count. No detailed reviews are supplied to identify recurring complaints or sleep and mood experiences.

Value for money

47 Lower impact

Meaningful tryptophan and 5-hydroxytryptophan amounts provide some formula substance. A very short supply, hidden blend, and interaction-prone design make practical value weak.

Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
A- Goal FitB+ Strength of SupportB CoverageB- Formula Quality
Vitamin B6 · 20 mgMagnesium · 40 mgVitamin D · 25 mcg5-HTP · 150 mg

5-HTP and tryptophan strongly target serotonin production, with vitamin B6 supplying a relevant cofactor. Vitamin D and magnesium add foundational support, though the magnesium amount is small.

The proprietary tranquility blend prevents a complete assessment, and using two serotonin precursors creates some redundancy. Do not combine this formula with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonergic agents because 5-HTP and tryptophan can raise serotonin together.

Study evidence
5-HTP Supportive 9 studies
Magnesium Supportive 60 studies
Tryptophan Mixed 1 study
Vitamin B6 Supportive 19 studies
Vitamin D Supportive 163 studies
Sleep Support
Sleep Support
Impact
High effect
B Goal FitB- Strength of SupportB- CoverageC Formula Quality
Magnesium · 40 mg

Combining 400 mg of L-tryptophan with 150 mg of 5-HTP provides dual-pathway support for serotonin and melatonin synthesis. Magnesium bisglycinate chelate is included in its highly bioavailable form to aid physical relaxation and muscle recovery during rest.

The tranquility blend of botanical extracts helps manage evening stress to facilitate easier sleep onset. Comprehensive labeling of the primary amino acids allows for clear verification of the formula's significant potency levels.

Study evidence
5-HTP Supportive 1 study
Magnesium Supportive 23 studies
Tryptophan Mixed 1 study
Vitamin B6 Disputed 7 studies
Stress Relief
Stress Relief
Impact
High effect
B- Goal FitC Strength of SupportB- CoverageC Formula Quality
Vitamin D · 25 mcgMagnesium · 40 mgVitamin B6 · 20 mgTryptophan · 400 mg

Combining L-Tryptophan, 5-HTP, and a herbal tranquility blend provides multi-layered support for serotonin synthesis and nervous system relaxation. Magnesium bisglycinate and Vitamin B6 further contribute as essential cofactors in neurotransmitter pathways to help maintain emotional equilibrium.

High user satisfaction and the use of bioavailable mineral forms suggest a well-regarded option for navigating occasional stress. The selection of ingredients appears well aligned with those seeking to support mood stability and evening relaxation through diverse biological mechanisms.

Study evidence
5-HTP Supportive 18 studies
Magnesium Supportive 13 studies
Vitamin D Supportive 41 studies
Brain Health
Brain Health
Impact
Moderate effect
C- Goal FitD+ Strength of SupportD+ CoverageC- Formula Quality
Vitamin B6 · 20 mgVitamin D · 25 mcgMagnesium · 40 mg

L-tryptophan, 5-HTP, magnesium, and vitamin B6 support mood and relaxation through serotonin-related pathways. The formula has little direct coverage of memory, attention, or brain structure.

Tryptophan is below the preferred targeted range, and the proprietary botanical blend hides individual amounts. Combining L-tryptophan with 5-HTP may raise serotonin-related risk for people using SSRIs, MAO inhibitors, or triptan medicines.

Study evidence
Magnesium Supportive 86 studies
Vitamin B6 Supportive 29 studies
Weight Loss
Weight Loss
Impact
Moderate effect
D- Goal FitC Strength of SupportD CoverageC Formula Quality
Vitamin D · 25 mcgMagnesium · 40 mg

The 5-HTP and tryptophan amounts may support appetite control when cravings or emotional eating are tied to serotonin signaling. Evidence for meaningful weight change is limited, so the formula is better viewed as situational appetite support than a broad weight-management aid.

The mood-focused design does not raise metabolic rate or help preserve muscle during a calorie deficit. Combining 5-HTP and tryptophan can increase serotonin-related side effects, especially with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising medicines.

Study evidence
5-HTP Supportive 5 studies
Magnesium Supportive 17 studies

Ingredients

IngredientAmount per serving
Vitamin D (Cholecalciferol, Vitamin D3)
 25 mcg
Niacin (Inositol Hexanicotinate)
 30 mg NE
Vitamin B6 (Pyridoxine Hydrochloride)
 20 mg
Magnesium (Magnesium Bisglycinate Chelate)
 40 mg
Onnit Tranquility Blend
450 mg
L-Tryptophan
400 mg
5-Hydroxytryptophan
150 mg
Gluten Free Adults 18–50
Report overview
Vitamin B6 (Pyridoxine Hydrochloride) · 20 mg OverallScore56
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Pyridoxine hydrochloride is the sole disclosed B6 form and no riboflavin conversion support is listed. The 20 mg serving sits within the preferred range and below the chronic neuropathy ceiling. Value is poor for an inactive B6 form at this serving cost.

View ingredientView products
Tryptophan · 400 mg OverallScore48
D+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

The label clearly states the L-tryptophan amount, but the generic source has no purity or fermentation details. Its 400 mg dose remains below the preferred targeted range, while the calming blend avoids competing BCAAs. The combination of L-tryptophan and 5-HTP may increase serotonin-related risks with SSRIs, MAO inhibitors, or triptan medicines.

View ingredientView products
5-HTP · 150 mg OverallScore44
D Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value

A 150 mg amount supplies effective high-strength 5-HTP within a broader mood-support blend. Source standardization is absent, and the ordinary capsule does not provide optimized release or gastrointestinal protection. Very high cost per standard dose and missing serotonin-interaction warning information limit the formula's 5-HTP value.

View ingredientView products
Loading alternative details
90 Performance

Sleep Nighttime Powder

youtheory
<p>Glycine, magnesium citrate, L-theanine, low-dose melatonin, tryptophan, and 5-HTP create a more complete and fully disclosed nighttime formula. Combining both serotonin precursors still raises interaction concerns with serotonergic medicines, but the sleep-focused doses are easier to assess.</p>
88 Performance

MetaCalm

Metabolic Maintenance
<p>Magnesium glycinate, GABA, taurine, L-theanine, and 5-HTP form a coherent calming blend with active B6 and full dose disclosure. It avoids added tryptophan but remains expensive, and 5-HTP can still interact with serotonin-raising medicines.</p>
64 Performance

New MOOD

Onnit
<p>The same tryptophan, 5-HTP, magnesium, vitamin D, B6, and tranquility-blend design closely matches the original formula. It offers no meaningful ingredient improvement and costs more per serving, so its main advantage is merely being an equivalent listed option.</p>
83 Budget

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
<p>A clearly disclosed 5-HTP amount with vitamin C and lower B6 provides a simpler mood and sleep formula at a much lower serving cost. It omits tryptophan, magnesium, vitamin D, and the tranquility blend, while 5-HTP still requires caution with serotonin-raising medicines.</p>
82 Budget

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
<p>A focused 5-HTP formula uses less vitamin B6 and costs far less per serving. The narrower design avoids combining tryptophan with 5-HTP, though it also loses magnesium, vitamin D, and any ingredients hidden in the original tranquility blend.</p>
72 Budget

5-HTP 200 mg

NutraBio
<p>A clearly disclosed 5-HTP amount is available at a much lower serving cost, but its B6 amount is even more aggressive than the original. The single serotonin precursor is simpler than the original pairing, yet interaction concerns with serotonin-raising medicines remain.</p>
91 Value

Sleep Nighttime Powder

youtheory
<p>Glycine, magnesium citrate, L-theanine, low-dose melatonin, tryptophan, and 5-HTP provide broader disclosed sleep support for much less per serving. The dual serotonin precursors still require medication caution, but dose transparency and practical value are substantially better.</p>
82 Value

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
<p>The low-cost formula keeps a useful 5-HTP amount while reducing B6 and removing the hidden tranquility blend. It gives up magnesium, vitamin D, and tryptophan, yet the simpler approach offers strong value when 5-HTP is the intended active.</p>
84 Value

MetaCalm

Metabolic Maintenance
<p>Magnesium glycinate, GABA, taurine, L-theanine, and 5-HTP offer better disclosed calming depth at a slightly lower serving cost. The formula remains expensive and can add to sedation or interact with serotonin-raising medicines, but ingredient value is clearer.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  2. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  3. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  4. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  5. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  6. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  7. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  8. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  9. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  10. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  11. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  12. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study.
    Sarzi Puttini P; Caruso I · The Journal of international medical research · 1992
    Single-arm trial50 participantsStress Relief for5-HTP
  13. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  14. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  15. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  16. Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
    Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
    Clinical trial120 participantsStress Relief for5-HTP
  17. Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies.
    Sobczak S; Honig A; van Duinen MA; Riedel WJ · Bipolar disorders · 2003
    Systematic review15 studies pooledStress Relief for5-HTP
  18. Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
    Bertolini F; Robertson L; Bisson JI; Meader N; Churchill R; Ostuzzi G; Stein DJ; Williams T; Barbui C · The Cochrane database of systematic reviews · 2022
    Systematic review2,023 participants13 studies pooledStress Relief for5-HTP
  19. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  20. Gastrointestinal distress to serotonergic challenge: a risk marker for emotional disorder?
    Campo JV; Dahl RE; Williamson DE; Birmaher B; Perel JM; Ryan ND · Journal of the American Academy of Child and Adolescent Psychiatry · 2003
    Cohort study23 participantsStress Relief for5-HTP
  21. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  22. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  23. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  24. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  25. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  26. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledBrain Health forVitamin B6
  27. Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
    Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
    Cross-sectional study266 participantsBrain Health forVitamin B6
  28. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
    Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Randomized trial180 participantsBrain Health forVitamin B6
  29. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsBrain Health forVitamin B6
  30. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
    Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
    Scoping review12 studies pooledBrain Health forVitamin B6
  31. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  32. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  33. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  34. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  35. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  36. A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning
    Kikuchi AM, Tanabe A, Iwahori Y · Journal of Dietary Supplements · 2021
    Systematic review11 studies pooledMood Support forTryptophan
  37. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  38. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support forVitamin B6
  39. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  40. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  41. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  42. Meta-analysis of the effect of vitamin D on depression.
    Wang L; Su S; Liu Y · Frontiers in psychiatry · 2025
    Meta-analysis20 studies pooledMood Support forVitamin D
  43. A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers.
    Vaziri F; Nasiri S; Tavana Z; Dabbaghmanesh MH; Sharif F; Jafari P · BMC pregnancy and childbirth · 2017
    Randomized trial169 participantsMood Support forVitamin D
  44. Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort.
    Ronaldson A; Arias de la Torre J; Gaughran F; Bakolis I; Hatch SL; Hotopf M; Dregan A · Psychological medicine · 2022
    Cohort study139,128 participantsMood Support forVitamin D
  45. Association Between Low Vitamin D Levels and Depression: A Systematic Review and Meta-Analysis.
    Karim S; Natche J; Babli SA; Avinash; Matakhov D; Ferdous S; Jeyakkodi H; Alamu OS; Rizwanullah U; Hameed SA · Cureus · 2026
    Meta-analysis49,931 participants15 studies pooledMood Support forVitamin D
  46. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study.
    Zaromytidou E; Koufakis T; Dimakopoulos G; Drivakou D; Konstantinidou S; Rakitzi P; Grammatiki M; Manthou E; Notopoulos A; Iakovou I; Gotzamani-Psarrakou A; Kotsa K · Metabolites · 2023
    Randomized trial90 participantsMood Support Stress Relief forVitamin D
  47. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  48. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  49. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  50. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  51. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  52. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
    Clarinda N Sutanto, Wen Wei Loh, Jung Eun Kim · Nutrition Reviews · 2022
    Meta-analysis4 studies pooledSleep Support forTryptophan
  53. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  54. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  55. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  56. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  57. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  58. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  59. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  60. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  61. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  62. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
    Charoenporn V; Tungsukruthai P; Teacharushatakit P; Hanvivattanakul S; Sriyakul K; Sukprasert S; Kamalashiran C; Tungsukruthai S; Charernboon T · Psychiatry and clinical neurosciences · 2024
    Randomized trial80 participantsStress Relief forVitamin D
  63. The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review.
    Głąbska D; Kołota A; Lachowicz K; Skolmowska D; Stachoń M; Guzek D · Nutrients · 2021
    Systematic review24 studies pooledStress Relief forVitamin D
  64. Vitamin D3 enhances mood in healthy subjects during winter.
    Lansdowne AT; Provost SC · Psychopharmacology · 1998
    Randomized trial44 participantsStress Relief forVitamin D
  65. Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism: A Randomized Clinical Trial.
    Shoji T; Nakatani S; Kabata D; Mori K; Shintani A; Yoshida H; Takahashi K; Ota K; Fujii H; Ueda S; Nishi S; Nakatani T; Yoshiyama M; Goto K; Hamada T; Imanishi M; Ishimura E; Kagitani S; Kato Y; Kumeda Y; Maekawa K; Matsumura T; Nagayama H; Obi Y; Ohno Y; Sai Y; Sakurai M; Sasaki S; Shidara K; Shoji S; Tsujimoto Y; Yamakawa K; Yasuda H; Yodoi S; Inaba M; Emoto M · Clinical journal of the American Society of Nephrology : CJASN · 2021
    Randomized trial326 participantsStress Relief forVitamin D
  66. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  67. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  68. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  69. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  70. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP
  71. Magnesium intake is inversely associated with risk of obesity in a 30-year prospective follow-up study among American young adults.
    Lu L; Chen C; Yang K; Zhu J; Xun P; Shikany JM; He K · European journal of nutrition · 2021
    Cohort study5,115 participantsWeight Loss forMagnesium
  72. Clinical and Metabolic Responses to Magnesium Supplementation in Women with Polycystic Ovary Syndrome.
    Farsinejad-Marj M; Azadbakht L; Mardanian F; Saneei P; Esmaillzadeh A · Biological trace element research · 2021
    Randomized trial60 participantsWeight Loss forMagnesium
  73. An inverse association between magnesium in 24-h urine and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations.
    Yamori Y; Sagara M; Mizushima S; Liu L; Ikeda K; Nara Y; CARDIAC Study Group · Hypertension research : official journal of the Japanese Society of Hypertension · 2015
    Cross-sectional study4,211 participantsWeight Loss forMagnesium
  74. The effect of magnesium supplementation on anthropometric indices: a systematic review and dose-response meta-analysis of clinical trials.
    Rafiee M; Ghavami A; Rashidian A; Hadi A; Askari G · The British journal of nutrition · 2021
    Meta-analysis2,013 participants28 studies pooledWeight Loss forMagnesium
  75. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials.
    Askari M; Mozaffari H; Jafari A; Ghanbari M; Darooghegi Mofrad M · Critical reviews in food science and nutrition · 2021
    Meta-analysis32 studies pooledWeight Loss forMagnesium