Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
Meta-analysis1,998 participants34 studies pooledflagSleep Support forscienceMelatonin
- Diagnosis of magnesium-induced diarrhea.
Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
Clinical trial19 participantsflagDigestive Health forscienceMagnesium
- No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial.
Kücükakin B; Wilhelmsen M; Lykkesfeldt J; Reiter RJ; Rosenberg J; Gögenur I · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2010
Randomized trial50 participantsflagStress Relief forscienceMelatonin
- L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
Randomized trial46 participantsflagSleep Support forscienceTheanine
- Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
Clinical trial120 participantsflagStress Relief forscience5-HTP
- The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
Randomized trial30 participantsflagSleep Support forscience5-HTP
- The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
Soh J; Raventhiran S; Lee JH; Lim ZX; Goh J; Kennedy BK; Maier AB · GeroScience · 2024
Systematic reviewflagSleep Support forscienceGlycine
- Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
Meta-analysis516 participants8 studies pooledflagSleep Support forscienceMelatonin
- Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
Randomized trial49 participantsflagDigestive Health forscienceMagnesium
- Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial.
Pachimsawat P; Ratanachamnong P; Jantaratnotai N · Pharmacology research & perspectives · 2024
Randomized trial64 participantsflagStress Relief forscienceMelatonin
- Gastrointestinal distress to serotonergic challenge: a risk marker for emotional disorder?
Campo JV; Dahl RE; Williamson DE; Birmaher B; Perel JM; Ryan ND · Journal of the American Academy of Child and Adolescent Psychiatry · 2003
Cohort study23 participantsflagStress Relief forscience5-HTP
- Current Evidence on Common Dietary Supplements for Sleep Quality.
Esquivel MK; Ghosn B · American journal of lifestyle medicine · 2025
Narrative reviewflagSleep Support forscienceTheanine
- New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
Bannai M; Kawai N · Journal of pharmacological sciences · 2012
Narrative reviewflagSleep Support forscienceGlycine
- Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.
Kubota M; Ito K; Tomimoto K; Kanazaki M; Tsukiyama K; Kubota A; Kuroki H; Fujita M; Vandenplas Y · Nutrients · 2020
Randomized trial60 participantsflagDigestive Health forscienceMagnesium
- The Biological Clock Influenced by Burnout, Hormonal Dysregulation and Circadian Misalignment: A Systematic Review.
Ungurianu A; Marina V · Clocks & sleep · 2025
Systematic review195 participants37 studies pooledflagStress Relief forscienceMelatonin
- Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
Peltz JS; Rogge R · Sleep and biological rhythms · 2025
Cohort study331 participantsflagSleep Support forscienceMelatonin
- Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
Randomized trial30 participantsflagSleep Support flagBrain Health flagCognitive Support forscienceTheanine
- Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
Randomized trial45 participantsflagStress Relief forscience5-HTP
- The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
Bannai M; Kawai N; Ono K; Nakahara K; Murakami N · Frontiers in neurology · 2012
Clinical trial7 participantsflagSleep Support forscienceGlycine
- Meta-analysis: melatonin for the treatment of primary sleep disorders.
Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
Meta-analysis1,683 participants19 studies pooledflagSleep Support forscienceMelatonin
- A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
Randomized trial34 participantsflagDigestive Health forscienceMagnesium
- Melatonin for pre- and postoperative anxiety in adults.
Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
Meta-analysis774 participants12 studies pooledflagStress Relief forscienceMelatonin
- Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
Randomized trial120 participantsflagSleep Support forscienceTheanine
- Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
Randomized trial48 participantsflagStress Relief forscience5-HTP
- Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis.
Li T; Jiang S; Han M; Yang Z; Lv J; Deng C; Reiter RJ; Yang Y · Frontiers in neuroendocrinology · 2019
Meta-analysis205 participants7 studies pooledflagSleep Support forscienceMelatonin
- The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
Meta-analysis787 participants8 studies pooledflagDigestive Health forscienceMagnesium
- Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
Randomized trial90 participantsflagStress Relief forscienceMelatonin
- Theanine maintains sleep quality in healthy young women by suppressing the increase in caffeine-induced wakefulness after sleep onset.
Baba Y; Takihara T; Okamura N · Food & function · 2023
Clinical trialflagSleep Support forscienceTheanine
- Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
Bertolini F; Robertson L; Bisson JI; Meader N; Churchill R; Ostuzzi G; Stein DJ; Williams T; Barbui C · The Cochrane database of systematic reviews · 2022
Systematic review2,023 participants13 studies pooledflagStress Relief forscience5-HTP
- Melatonin Treatment for Sleep Disorders in Parkinson's Disease: A Meta-Analysis and Systematic Review.
Ma H; Yan J; Sun W; Jiang M; Zhang Y · Frontiers in aging neuroscience · 2022
Meta-analysis7 studies pooledflagSleep Support forscienceMelatonin
- Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation.
Bu LN; Chang MH; Ni YH; Chen HL; Cheng CC · Pediatrics international : official journal of the Japan Pediatric Society · 2007
Randomized trial45 participantsflagDigestive Health forscienceMagnesium
- The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
Randomized trial202 participantsflagStress Relief forscienceMelatonin
- To sleep or not to sleep: a systematic review of the literature of pharmacological treatments of insomnia in children and adolescents with attention-deficit/hyperactivity disorder.
Barrett JR; Tracy DK; Giaroli G · Journal of child and adolescent psychopharmacology · 2014
Systematic review5 studies pooledflagSleep Support forscienceTheanine
- Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
Randomized trialflagStress Relief forscience5-HTP
- Effects of Melatonin Treatment on Perioperative Sleep Quality: A Systematic Review and Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials.
Gao Y; Chen X; Zhou Q; Song J; Zhang X; Sun Y; Yu M; Li Y · Nature and science of sleep · 2022
Meta-analysis725 participants10 studies pooledflagSleep Support forscienceMelatonin
- Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
Randomized trial100 participantsflagDigestive Health forscienceMagnesium
- A systematic review of peri-operative melatonin.
Andersen LP; Werner MU; Rosenberg J; Gögenur I · Anaesthesia · 2014
Meta-analysis1,794 participants24 studies pooledflagStress Relief forscienceMelatonin
- The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
Meta-analysis897 participants19 studies pooledflagSleep Support forscienceTheanine
- Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
Randomized trialflagStress Relief forscience5-HTP
- Melatonin treatment for age-related insomnia.
Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
Randomized trial30 participantsflagSleep Support forscienceMelatonin
- Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
Randomized trial240 participantsflagDigestive Health forscienceMagnesium
- Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
Meta-analysis441 participants5 studies pooledflagStress Relief forscienceMelatonin
- In Search of a Safe Natural Sleep Aid.
Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
Narrative reviewflagSleep Support forscienceTheanine
- Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies.
Sobczak S; Honig A; van Duinen MA; Riedel WJ · Bipolar disorders · 2003
Systematic review15 studies pooledflagStress Relief forscience5-HTP
- Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
Sletten TL; Magee M; Murray JM; Gordon CJ; Lovato N; Kennaway DJ; Gwini SM; Bartlett DJ; Lockley SW; Lack LC; Grunstein RR; Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group · PLoS medicine · 2019
Randomized trial116 participantsflagSleep Support forscienceMelatonin
- The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
Randomized trial286 participantsflagDigestive Health forscienceMagnesium
- Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
Randomized trial88 participantsflagStress Relief forscienceMelatonin
- An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
Single-arm trial15 participantsflagStress Relief forscience5-HTP
- The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
Meta-analysis409 participants8 studies pooledflagSleep Support forscienceMelatonin
- Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial.
Yoneda H; Tomita T; Kitano T; Morishita D; Kodani M; Nishii N; Sei H; Eda H; Sato T; Kawai M; Yokoyama Y; Igeta M; Okugawa T; Fukui H; Shinzaki S · Neurogastroenterology and motility · 2026
Randomized trial40 participantsflagDigestive Health forscienceMagnesium
- Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men: a randomized placebo-controlled study.
Wirtz PH; Bärtschi C; Spillmann M; Ehlert U; von Känel R · Journal of pineal research · 2008
Randomized trial45 participantsflagStress Relief forscienceMelatonin
- Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study.
Sarzi Puttini P; Caruso I · The Journal of international medical research · 1992
Single-arm trial50 participantsflagStress Relief forscience5-HTP
- Accelerated biological aging, mediating amino acids, and risk of incident type 2 diabetes: a prospective cohort study.
Zhang Z; Wang J; Yu B; Sun Y; Chen Y; Lu Y; Wang N; Xia F · Journal of endocrinological investigation · 2025
Cohort study95,773 participantsflagAnti-Aging forscienceGlycine
- Dietary protein and amino acid intakes for mitigating sarcopenia in humans.
He W; Connolly ED; Cross HR; Wu G · Critical reviews in food science and nutrition · 2025
Narrative reviewflagAnti-Aging forscienceGlycine
- Age-Related Neurochemical Changes in the Vestibular Nuclei.
Smith PF · Frontiers in neurology · 2016
Narrative reviewflagAnti-Aging forscienceGlycine
- SHMT2 regulates CD8+ T cell senescence via the reactive oxygen species axis in HIV-1 infected patients on antiretroviral therapy.
Zhang QS; Wang JN; Yang TL; Li SY; Li JQ; Liu DN; Shang H; Zhang ZN · EBioMedicine · 2025
Observational studyflagAnti-Aging forscienceGlycine
- Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study.
Cui M; Jiang Y; Zhao Q; Zhu Z; Liang X; Zhang K; Wu W; Dong Q; An Y; Tang H; Ding D; Chen X · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
Cohort studyflagAnti-Aging forscienceGlycine
- Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.
Shang Y; Song N; He R; Wu M · Advances in nutrition (Bethesda, Md.) · 2024
Meta-analysis2,617 participants20 studies pooledflagAnti-Aging forscienceMelatonin
- Lipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial.
Colombo F; Alfano S; Milani M · Metabolites · 2025
Randomized trial39 participantsflagAnti-Aging forscienceMelatonin
- Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age.
Tsui KH; Li CJ; Lin LT · Reproductive biology and endocrinology : RB&E · 2024
Cohort study161 participantsflagAnti-Aging forscienceMelatonin
- Melatonin and healthy aging.
Cardinali DP · Vitamins and hormones · 2021
Narrative reviewflagAnti-Aging forscienceMelatonin
- Clinical Studies Using Topical Melatonin.
Greco G; Di Lorenzo R; Ricci L; Di Serio T; Vardaro E; Laneri S · International journal of molecular sciences · 2024
Narrative reviewflagAnti-Aging forscienceMelatonin
- Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.
Cruz M; Maldonado-Bernal C; Mondragón-Gonzalez R; Sanchez-Barrera R; Wacher NH; Carvajal-Sandoval G; Kumate J · Journal of endocrinological investigation · 2009
Randomized trial74 participantsflagAnti-Inflammatory Support forscienceGlycine
- Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.
Vargas MH; Del-Razo-RodrÃguez R; López-GarcÃa A; Lezana-Fernández JL; Chávez J; Furuya MEY; MarÃn-Santana JC · BMC pulmonary medicine · 2018
Randomized trial13 participantsflagAnti-Inflammatory Support forscienceGlycine
- Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing.
Guo X; Bai H; Lu X; Guo J; Qi Y; Huo X; Li S · Clinical oral investigations · 2026
Randomized trial80 participantsflagAnti-Inflammatory Support forscienceGlycine
- Long-term Implant Maintenance: A Systematic Review of Home and Professional Care Strategies in Supportive Implant Therapy.
Araújo TG; Moreira CS; Neme RA; Luan H; Bertolini M · Brazilian dental journal · 2024
Systematic review13 studies pooledflagAnti-Inflammatory Support forscienceGlycine
- Analysis of the factors influencing the occurrence of peri-implantitis in patients with implant-supported restoration and study on the maintenance effect of subgingival sandblasting.
Pan T; Meng W; Zhang M; Xie Y; Chen Z; Zhou M; Yin L; Xie H · BMC oral health · 2026
Randomized trial198 participantsflagAnti-Inflammatory Support forscienceGlycine
- Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review.
Dibaba DT; Xun P; He K · European journal of clinical nutrition · 2014
Meta-analysis32,918 participants7 studies pooledflagAnti-Inflammatory Support forscienceMagnesium
- Efficacy and safety of magnesium glycinate as add on therapy in hypomagnesemic asthma and chronic obstructive pulmonary disease patients: A randomised controlled study assessing inflammatory biomarkers.
Maddirevula MK; Rajanandh MG; Wesley B · Pulmonary pharmacology & therapeutics · 2026
Randomized trial224 participantsflagAnti-Inflammatory Support forscienceMagnesium
- Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
Razzaghi R; Pidar F; Momen-Heravi M; Bahmani F; Akbari H; Asemi Z · Biological trace element research · 2018
Randomized trial70 participantsflagAnti-Inflammatory Support forscienceMagnesium
- The effect of long-term magnesium intake on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
Wang W; Wang J; Yang Y; Shi Y · Frontiers in nutrition · 2025
Meta-analysis444 participants8 studies pooledflagAnti-Inflammatory Support forscienceMagnesium
- Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.
Veronese N; Pizzol D; Smith L; Dominguez LJ; Barbagallo M · Nutrients · 2022
Meta-analysis889 participants17 studies pooledflagAnti-Inflammatory Support forscienceMagnesium
- Implantoplasty Versus Glycine Air Abrasion for the Surgical Treatment of Peri-implantitis: A Randomized Clinical Trial.
Lasserre JF; Brecx MC; Toma S · The International journal of oral & maxillofacial implants · 2020
Randomized trial31 participantsflagBone Health forscienceGlycine
- Amino Acid Intakes Are Associated With Bone Mineral Density and Prevalence of Low Bone Mass in Women: Evidence From Discordant Monozygotic Twins.
Jennings A; MacGregor A; Spector T; Cassidy A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
Cross-sectional study135 participantsflagBone Health forscienceGlycine
- Type V osteogenesis imperfecta: a new form of brittle bone disease.
Glorieux FH; Rauch F; Plotkin H; Ward L; Travers R; Roughley P; Lalic L; Glorieux DF; Fassier F; Bishop NJ · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2001
Other3 participantsflagBone Health forscienceGlycine
- Associations of Dietary and Circulating Choline and Glycine With Bone Mineral Density: UK Biobank Analyses With Mendelian Randomization.
Chen S; Lu R; Zhang Y; Li Y; Cao X; Yang H; Lin J · International journal of endocrinology · 2026
Cross-sectional study18,769 participantsflagBone Health forscienceGlycine
- Metabolomic insights into amino acid signatures and pathways associated with osteoporosis in Iranian elderly population.
Dehghanbanadaki H; Soltani A; Majidi Z; Rezaei-Tavirani M; Shafiee G; Ostovar A; Bandarian F; Najjar N; Larijani B; Nabipour I; Khashayar P; Fahimfar N; Razi F · Frontiers in medicine · 2025
Cross-sectional study1,916 participantsflagBone Health forscienceGlycine
- Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
Meta-analysis119,755 participants4 studies pooledflagBone Health forscienceMagnesium
- Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
Systematic review386 participants8 studies pooledflagBone Health forscienceMagnesium
- Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
Randomized trial48 participantsflagBone Health forscienceMagnesium
- An update on magnesium and bone health.
Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
Narrative reviewflagBone Health forscienceMagnesium
- Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
Cross-sectional study1,343 participantsflagBone Health forscienceMagnesium
- Antenatal magnesium sulfate and neuroprotection.
Doyle LW · Current opinion in pediatrics · 2012
Meta-analysis6,145 participants5 studies pooledflagBrain Health forscienceMagnesium
- No. 376-Magnesium Sulphate for Fetal Neuroprotection.
Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
Guideline / consensus4,446 participantsflagBrain Health forscienceMagnesium
- Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
Systematic review5,917 participants6 studies pooledflagBrain Health forscienceMagnesium
- Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
Meta-analysis5,917 participants6 studies pooledflagBrain Health forscienceMagnesium
- Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
Chollat C; Marret S · Neural regeneration research · 2020
Narrative reviewflagBrain Health forscienceMagnesium
- Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
Meta-analysis4,599 participants10 studies pooledflagBrain Health forscienceMelatonin
- Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
Meta-analysis516 participants10 studies pooledflagBrain Health forscienceMelatonin
- Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
Randomized trial80 participantsflagBrain Health forscienceMelatonin
- Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
Randomized trial54 participantsflagBrain Health forscienceMelatonin
- Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
Meta-analysis788 participants9 studies pooledflagBrain Health forscienceMelatonin
- A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
Randomized trialflagBrain Health flagStress Relief forscienceTheanine
- Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
Meta-analysis50 studies pooledflagBrain Health flagCognitive Support flagMental Focus forscienceTheanine
- Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
Randomized trial27 participantsflagBrain Health flagCognitive Support forscienceTheanine
- Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
Randomized trialflagBrain Health flagMental Focus flagProductivity Boost forscienceTheanine
- Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
Meta-analysis313,041 participants16 studies pooledflagCardiovascular Support forscienceMagnesium
- Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
Meta-analysis532,979 participants19 studies pooledflagCardiovascular Support forscienceMagnesium
- Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
Meta-analysis544,581 participants18 studies pooledflagCardiovascular Support flagHeart Health forscienceMagnesium
- Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
Meta-analysisflagCardiovascular Support flagHeart Health forscienceMagnesium
- Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
Meta-analysis200,934 participants20 studies pooledflagCardiovascular Support forscienceMagnesium
- Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
Doyle LW; Crowther CA; Middleton P; Marret S; Rouse D · The Cochrane database of systematic reviews · 2009
Meta-analysis6,145 participants5 studies pooledflagCognitive Support forscienceMagnesium
- Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis.
Zhang C; Sun L; Sun H · Medicine · 2022
Meta-analysis1,899 participants22 studies pooledflagCognitive Support forscienceMagnesium
- Effects of magnesium supplementation on serum brain-derived neurotrophic factor levels and cognitive function in patients undergoing fluoxetine therapy for depression.
Noor NJ; Syamsuddin S; Liaury K; Tawali S; Idris I; Azis I; Lisal ST · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
Randomized trial40 participantsflagCognitive Support forscienceMagnesium
- Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
Randomized trial80 participantsflagCognitive Support flagEnergy forscienceMagnesium
- Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?
Hassan WF; Tawfik MH; Nabil TM; Abd Elkareem RM · Minerva anestesiologica · 2021
Randomized trial80 participantsflagCognitive Support forscienceMagnesium
- Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
Randomized trial32 participantsflagCognitive Support forscienceTheanine
- Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
Clinical trial20 participantsflagCognitive Support flagMental Focus forscienceTheanine
- The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
Cohort study42 participantsflagDetoxification forscienceGlycine
- Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
Single-arm trial19 participantsflagDetoxification forscienceGlycine
- Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
Non-randomized trial21 participantsflagDetoxification forscienceGlycine
- Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
Methods validation study74 participantsflagDetoxification forscienceGlycine
- The treatment of isovaleric acidemia with glycine supplement
M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
Non-randomized trial2 participantsflagDetoxification forscienceGlycine
- Oral or nasogastric maintenance therapy for diarrhoea of unknown aetiology resembling cholera.
Nalin DR; Cash RA · Transactions of the Royal Society of Tropical Medicine and Hygiene · 1971
Clinical trialflagDigestive Health forscienceGlycine
- Prevention and treatment of infectious diarrhea. Speculations on the next 10 years.
Edelman R · The American journal of medicine · 1985
Narrative reviewflagDigestive Health forscienceGlycine
- Super ORS.
Bhattacharya SK; Dutta P; Dutta D; Chakraborti MK · Indian journal of public health · 1991
Narrative reviewflagDigestive Health forscienceGlycine
- A comparative study of glycine fortified oral rehydration solution with standard WHO oral rehydration solution.
Antony TJ; Mohan M · Indian pediatrics · 1990
Randomized trial50 participantsflagDigestive Health forscienceGlycine
- Rice-powder salt solution in the treatment of acute diarrhea in young children.
Sabchareon A; Chongsuphajaisiddhi T; Kittikoon P; Chanthavanich P · The Southeast Asian journal of tropical medicine and public health · 1993
Randomized trial64 participantsflagDigestive Health forscienceGlycine
- Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
Randomized trial240 participantsflagDigestive Health forscienceMagnesium
- Total magnesium intake and risk of frailty in older women.
Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
Cohort study81,524 participantsflagEnergy forscienceMagnesium
- Red blood cell magnesium and chronic fatigue syndrome.
Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
Randomized trial32 participantsflagEnergy forscienceMagnesium
- Exercise, magnesium and immune function.
Laires MJ; Monteiro C · Magnesium research · 2008
Narrative reviewflagEnergy forscienceMagnesium
- Air-abrasive debridement with glycine powder versus manual debridement and chlorhexidine administration for the maintenance of peri-implant health status: a six-month randomized clinical trial.
Lupi SM; Granati M; Butera A; Collesano V; Rodriguez Y Baena R · International journal of dental hygiene · 2018
Randomized trial46 participantsflagGeneral Health forscienceGlycine
- The effects of glycine on auditory mismatch negativity in schizophrenia.
Greenwood LM; Leung S; Michie PT; Green A; Nathan PJ; Fitzgerald P; Johnston P; Solowij N; Kulkarni J; Croft RJ · Schizophrenia research · 2018
Randomized trial22 participantsflagGeneral Health forscienceGlycine
- Dietary glycine improves urine storage symptoms in urology outpatients.
Sugaya K; Oh-Oka H; Yamada T; Miyata M; Ashitomi K; Kadekawa K; Nishijima S · Journal of complementary & integrative medicine · 2021
Non-randomized trial20 participantsflagGeneral Health forscienceGlycine
- Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.
DÃaz-Flores M; Cruz M; Duran-Reyes G; Munguia-Miranda C; Loza-RodrÃguez H; Pulido-Casas E; Torres-RamÃrez N; Gaja-Rodriguez O; Kumate J; Baiza-Gutman LA; Hernández-Saavedra D · Canadian journal of physiology and pharmacology · 2014
Randomized trial60 participantsflagGeneral Health flagStress Relief forscienceGlycine
- Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
Meta-analysis1,257 participants20 studies pooledflagGeneral Health forscienceMagnesium
- Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
Woods KL; Fletcher S · Lancet (London, England) · 1994
Randomized trial2,316 participantsflagGeneral Health forscienceMagnesium
- Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
Cohort study10,999 participantsflagGeneral Health forscienceMagnesium
- Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
Cohort study9,359 participantsflagGeneral Health forscienceMagnesium
- The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
Randomized trial64 participantsflagGeneral Health forscienceMagnesium
- Melatonin for preventing and treating jet lag.
Herxheimer A; Petrie KJ · The Cochrane database of systematic reviews · 2001
Systematic review10 studies pooledflagGeneral Health forscienceMelatonin
- Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.
Schroder CM; Malow BA; Maras A; Melmed RD; Findling RL; Breddy J; Nir T; Shahmoon S; Zisapel N; Gringras P · Journal of autism and developmental disorders · 2019
Randomized trial125 participantsflagGeneral Health forscienceMelatonin
- Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
Fatemeh G; Sajjad M; Niloufar R; Neda S; Leila S; Khadijeh M · Journal of neurology · 2022
Meta-analysis23 studies pooledflagGeneral Health forscienceMelatonin
- Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses.
Choi K; Lee YJ; Park S; Je NK; Suh HS · Sleep medicine reviews · 2022
Meta-analysis24 studies pooledflagGeneral Health forscienceMelatonin
- Effectiveness of melatonin for the treatment of nocturia: a randomized controlled trial.
Leerasiri P; Pariyaeksut P; Hengrasmee P; Asumpinwong C · International urogynecology journal · 2023
Randomized trial60 participantsflagGeneral Health forscienceMelatonin
- Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
Meta-analysis1,325 participants24 studies pooledflagHeart Health forscienceMagnesium
- The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
Guerrero-Romero F; RodrÃguez-Morán M · Journal of human hypertension · 2009
Randomized trial82 participantsflagHeart Health forscienceMagnesium
- Positive effects of magnesium supplementation in metabolic syndrome.
Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
Randomized trial54 participantsflagHeart Health forscienceMagnesium
- Relationship between Whole-Blood Magnesium and Cognitive Performance among Chinese Adults.
Lu Z; He R; Zhang Y; Li B; Li F; Fu Y; Rong S · Nutrients · 2023
Cross-sectional study1,006 participantsflagMental Focus forscienceMagnesium
- Serum Magnesium and Cognitive Function Among Qatari Adults.
Al-Ghazali K; Eltayeb S; Musleh A; Al-Abdi T; Ganji V; Shi Z · Frontiers in aging neuroscience · 2020
Cross-sectional study1,000 participantsflagMental Focus forscienceMagnesium
- Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis.
Effatpanah M; Rezaei M; Effatpanah H; Effatpanah Z; Varkaneh HK; Mousavi SM; Fatahi S; Rinaldi G; Hashemi R · Psychiatry research · 2019
Meta-analysisflagMental Focus forscienceMagnesium
- The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial.
Hemamy M; Pahlavani N; Amanollahi A; Islam SMS; McVicar J; Askari G; Malekahmadi M · BMC pediatrics · 2021
Randomized trial33 participantsflagMental Focus forscienceMagnesium
- The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
Randomized trial100 participantsflagMental Focus flagProductivity Boost forscienceMagnesium
- Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
Randomized trial30 participantsflagMental Focus flagProductivity Boost flagStress Relief forscienceTheanine
- Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
Randomized trial24 participantsflagMental Focus forscienceTheanine
- Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
Randomized trial70 participantsflagMood Support forscience5-HTP
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
Randomized trial30 participantsflagMood Support forscience5-HTP
- Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
Meta-analysis13 studies pooledflagMood Support forscience5-HTP
- Tryptophan and 5-hydroxytryptophan for depression.
Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
Systematic review64 participants2 studies pooledflagMood Support forscience5-HTP
- 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
Non-randomized trial30 participantsflagMood Support forscience5-HTP
- [Augmentation of antipsychotics with glycine may ameliorate depressive and extrapyramidal symptoms in schizophrenic patients--a preliminary 10-week open-label study].
Strzelecki D; Kropiwnicki P; Rabe-Jabłońska J · Psychiatria polska · 2014
Single-arm trial29 participantsflagMood Support forscienceGlycine
- Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
Pålsson E; Jakobsson J; Södersten K; Fujita Y; Sellgren C; Ekman CJ; Ågren H; Hashimoto K; Landén M · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015
Cross-sectional study327 participantsflagMood Support forscienceGlycine
- Erythrocyte glycine in depressed, hypomanic, and euthymic bipolar patients treated with lithium carbonate.
Peselow ED; Deutsch SI; Stanley M; Banay-Schwartz M; Virgilio J; Fieve RR · Psychopharmacology · 1983
Cross-sectional study27 participantsflagMood Support forscienceGlycine
- Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
Meta-analysis4,049 participants52 studies pooledflagMood Support forscienceMagnesium
- Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
Randomized trial126 participantsflagMood Support flagStress Relief forscienceMagnesium
- Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
Randomized trial40 participantsflagMood Support forscienceMagnesium
- The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
Randomized trial46 participantsflagMood Support forscienceMagnesium
- Dietary magnesium intake and risk of depression.
Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
Cross-sectional study17,730 participantsflagMood Support forscienceMagnesium
- l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
Randomized trial60 participantsflagMood Support forscienceTheanine
- L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
Randomized trial60 participantsflagMood Support flagStress Relief forscienceTheanine
- The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
Systematic review9 studies pooledflagMood Support forscienceTheanine
- Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
Randomized trial168 participantsflagMood Support flagStress Relief forscienceTheanine
- Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
Randomized trial20 participantsflagMood Support forscienceTheanine
- A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning
Kikuchi AM, Tanabe A, Iwahori Y · Journal of Dietary Supplements · 2021
Systematic review11 studies pooledflagMood Support forscienceTryptophan
- Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.
Tao MH; Chuang SC; Wu IC; Chan HT; Cheng CW; Chen HL; Lee MM; Chang HY; Hsiung CA; Hsu CC · European journal of nutrition · 2024
Cohort study5,663 participantsflagProductivity Boost forscienceMagnesium
- Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.
Tu X; Qiu H; Lin S; He W; Huang G; Zhang X; Wu Y; He J · Neuropsychiatric disease and treatment · 2022
Cohort study327 participantsflagProductivity Boost forscienceMagnesium
- Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
Lai XN; Sadhwani V; Ng WM; Gani A · Cureus · 2025
Cohort study667 participantsflagProductivity Boost forscienceMagnesium
- Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.
Chen M; Xue R; Zhang M; Zhang J; Zheng J; Ye D; Sun J · Journal of the American Medical Directors Association · 2025
Cross-sectional study2,768 participantsflagProductivity Boost forscienceMagnesium
- Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
Meta-analysis1,168 participants31 studies pooledflagProductivity Boost forscienceTheanine
- Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
Narrative reviewflagProductivity Boost forscienceTheanine
- Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
Randomized trial48 participantsflagProductivity Boost forscienceTheanine
- Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
Randomized trial320 participantsflagSleep Support forscienceMagnesium
- Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
Cohort study3,964 participantsflagSleep Support forscienceMagnesium
- Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
Randomized trial120 participantsflagSleep Support forscienceMagnesium
- The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
Randomized trial46 participantsflagSleep Support forscienceMagnesium
- A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
Randomized trial175 participantsflagSleep Support forscienceMagnesium
- Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
Randomized trial791 participantsflagSleep Support forscienceMelatonin
- Effects of exogenous melatonin on sleep: a meta-analysis.
Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
Meta-analysis284 participants8 studies pooledflagSleep Support forscienceMelatonin
- The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
Clarinda N Sutanto, Wen Wei Loh, Jung Eun Kim · Nutrition Reviews · 2022
Meta-analysis4 studies pooledflagSleep Support forscienceTryptophan
- Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
Randomized trial137 participantsflagStress Relief forscienceMagnesium
- Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
Non-randomized trial60 participantsflagStress Relief forscienceMagnesium
- Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
Randomized trial45 participantsflagStress Relief forscienceMagnesium
- Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
Randomized trialflagStress Relief forscienceMagnesium
- Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
Randomized trial34 participantsflagStress Relief forscienceTheanine
- Magnesium and anabolic hormones in older men.
Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
Cohort study399 participantsflagTestosterone Support forscienceMagnesium
- Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
Cross-sectional study313 participantsflagTestosterone Support forscienceMagnesium
- Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
Randomized trial64 participantsflagTestosterone Support forscienceMagnesium
- The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
Meta-analysis1,600 participants25 studies pooledflagTestosterone Support forscienceMagnesium
- Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
Non-randomized trial20 participantsflagTestosterone Support forscienceMagnesium
- Melatonin potentiates testosterone-induced suppression of luteinizing hormone secretion in normal men.
Anderson RA; Lincoln GA; Wu FC · Human reproduction (Oxford, England) · 1994
Randomized trial12 participantsflagTestosterone Support forscienceMelatonin
- Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.
Ziaei S; Hasani M; Malekahmadi M; Daneshzad E; Kadkhodazadeh K; Heshmati J · Journal of ovarian research · 2024
Meta-analysis6 studies pooledflagTestosterone Support forscienceMelatonin
- Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome.
Jamilian M; Foroozanfard F; Mirhosseini N; Kavossian E; Aghadavod E; Bahmani F; Ostadmohammadi V; Kia M; Eftekhar T; Ayati E; Mahdavinia M; Asemi Z · Frontiers in endocrinology · 2020
Randomized trial56 participantsflagTestosterone Support forscienceMelatonin
- A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone or cortisol.
Waldhauser F; Lieberman HR; Lynch HJ; Waldhauser M; Herkner K; Frisch H; Vierhapper H; Waldhäusl W; Schemper M; Wurtman RJ · Neuroendocrinology · 1987
Clinical trial24 participantsflagTestosterone Support forscienceMelatonin
- Melatonin administered in the afternoon decreases next-day luteinizing hormone levels in men: lack of antagonism by flumazenil.
Luboshitzky R; Shen-Orr Z; Shochat T; Herer P; Lavie P · Journal of molecular neuroscience : MN · 2000
Randomized trial6 participantsflagTestosterone Support forscienceMelatonin
- The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
Randomized trial48 participantsflagWeight Loss forscience5-HTP
- Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
Randomized trial25 participantsflagWeight Loss forscience5-HTP
- The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
Clinical trial19 participantsflagWeight Loss forscience5-HTP
- Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
Narrative reviewflagWeight Loss forscience5-HTP
- Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
Randomized trial20 participantsflagWeight Loss forscience5-HTP
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Lu L; Chen C; Yang K; Zhu J; Xun P; Shikany JM; He K · European journal of nutrition · 2021
Cohort study5,115 participantsflagWeight Loss forscienceMagnesium
- Clinical and Metabolic Responses to Magnesium Supplementation in Women with Polycystic Ovary Syndrome.
Farsinejad-Marj M; Azadbakht L; Mardanian F; Saneei P; Esmaillzadeh A · Biological trace element research · 2021
Randomized trial60 participantsflagWeight Loss forscienceMagnesium
- An inverse association between magnesium in 24-h urine and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations.
Yamori Y; Sagara M; Mizushima S; Liu L; Ikeda K; Nara Y; CARDIAC Study Group · Hypertension research : official journal of the Japanese Society of Hypertension · 2015
Cross-sectional study4,211 participantsflagWeight Loss forscienceMagnesium
- The effect of magnesium supplementation on anthropometric indices: a systematic review and dose-response meta-analysis of clinical trials.
Rafiee M; Ghavami A; Rashidian A; Hadi A; Askari G · The British journal of nutrition · 2021
Meta-analysis2,013 participants28 studies pooledflagWeight Loss forscienceMagnesium
- The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials.
Askari M; Mozaffari H; Jafari A; Ghanbari M; Darooghegi Mofrad M · Critical reviews in food science and nutrition · 2021
Meta-analysis32 studies pooledflagWeight Loss forscienceMagnesium