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Magnesium L-Threonate

4.8
★ ★ ★ ★ ★
(8708 ratings)
Magnesium 145 mg
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Score83
A correctly disclosed L-threonate serving provides 145 mg elemental magnesium in three capsules. The 30-serving supply is costly and offers no named patented sourcing advantage.
How scoring works
Capsule
Quantity:90 Capsule(s) • (30 servings)
Goals:
General Health
Stress Relief
Bone Health
Energy
Heart Health
Cardiovascular Support

Score 83

A correctly disclosed L-threonate serving provides 145 mg elemental magnesium in three capsules. The 30-serving supply is costly and offers no named patented sourcing advantage.
How scoring works

Also available as

1 option
270 servings Magnesium 145 mg • 270 Capsule(s) • 90 servings $86.97 ($0.96 per serving)
$27.72($0.92 per serving)
Vitacost
$ 43.75
iHerb
$ 38.50
Pure Formulas
$ 34.99
Amazon
$ 34.97
Walmart
$ 27.72
Vitacost
$ 43.75
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Analysis

Three capsules supply 2 g magnesium L-threonate, equal to 145 mg elemental magnesium. That yield is normal for L-threonate but provides less elemental magnesium than most standard replacement formulas.

The form is aimed at specialized nervous-system use rather than maximizing elemental intake. The supplied label does not identify Magtein or another patented material, so sourcing quality cannot be distinguished from generic L-threonate.

Only 30 servings are provided, and the serving cost is high despite the smaller bottle. It makes sense mainly for a targeted L-threonate trial, not for value-focused daily magnesium use.

Who is it for
  • Adults comfortable with capsules
  • Users seeking broad magnesium support
  • People who can account for dietary and supplemental magnesium
Best for
  • Routine magnesium supplementation
  • Muscle, nerve, and energy support
  • Capsules dosing

Pros

  • Uses magnesium L-threonate
  • States both compound and elemental amounts
  • Dose matches the expected elemental yield
  • Focused single-form formula

Cons

  • Only 30 servings
  • High cost per serving
  • Requires three capsules
  • No named patented source

Warnings

  • The 145 mg magnesium amount may still cause digestive symptoms in sensitive users
  • Kidney impairment can reduce magnesium clearance
  • Magnesium can reduce absorption of tetracycline or quinolone antibiotics and bisphosphonates when taken together

Nutrient quality

91 Highest impact

The amount avoids an obvious excessive-dose concern. The elemental amount is useful but modest or partly ambiguous.

Ingredient transparency

83 Highest impact

The active magnesium amount is specifically disclosed. A complete inactive ingredient list is not supplied.

Customer satisfaction

92 Highest impact

The large review count makes the aggregate rating highly reliable. Specific experiences are absent, but the strong aggregate rating is broadly consistent with satisfaction.

Value for money

66 High impact

The price is supported mainly by useful core ingredients. The serving cost is high relative to the disclosed formula.

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Goals

General Health
General Health
Impact
High effect
B+ Goal FitB Strength of SupportC CoverageA Formula Quality
Magnesium · 2000 mg

Magnesium L-threonate supplies a clearly disclosed amount of elemental magnesium in a specialized form. Magnesium supports nerve, muscle, and energy-related functions, while the threonate form is positioned more narrowly toward cognitive support.

The elemental amount is modest for filling a broad magnesium gap even though the compound amount is substantial. The simple formula and precise distinction between elemental magnesium and its source improve transparency.

Study evidence
Magnesium Supportive 114 studies
Stress Relief
Stress Relief
Impact
High effect
B Goal FitB Strength of SupportC- CoverageA+ Formula Quality
Magnesium · 2000 mg

Magnesium L-threonate provides a focused form of nervous-system support. It provides 145 mg of magnesium from 2,000 mg of magnesium L-threonate for the stated purpose.

The elemental amount is modest and the formula addresses only one stress pathway. Its focused design keeps the main benefits and limitations easy to assess.

Study evidence
Magnesium Supportive 13 studies
Bone Health
Bone Health
Impact
High effect
B- Goal FitB Strength of SupportC- CoverageA Formula Quality
Magnesium · 2000 mg

Magnesium is a structural bone mineral and helps activate vitamin D. The single-mineral focus does not provide calcium, vitamin K, or collagen support.

The 145 mg elemental amount is clearly stated, and L-threonate is specifically identified but prioritizes brain delivery rather than bone mineral value. Higher supplemental magnesium may cause diarrhea or abdominal discomfort in sensitive users.

Study evidence
Magnesium Supportive 48 studies
Energy
Energy
Impact
High effect
B Goal FitB- Strength of SupportD+ CoverageA+ Formula Quality
Magnesium · 2000 mg

The 145 mg magnesium amount supports ATP-related enzymes, nerve signaling, and muscle function. Energy benefits are most likely when magnesium intake is inadequate rather than as immediate stimulation.

L-threonate is a specialized and clearly disclosed form, but the elemental amount remains below the rubric's functional threshold. The amount is below the main energy-oriented target but is unlikely to create the digestive load of larger magnesium servings.

Study evidence
Magnesium Supportive 4 studies
Heart Health
Heart Health
Impact
High effect
C+ Goal FitB- Strength of SupportC- CoverageA+ Formula Quality
Magnesium · 2000 mg

Magnesium L-threonate provides 145 mg of elemental magnesium, giving modest foundational support for vascular and cardiac function. The form is designed mainly for brain exposure, and the amount is lower than common magnesium targets for cardiovascular supplementation.

Both elemental magnesium and compound weight are clearly stated across three capsules. The lower elemental amount may improve tolerance, but it leaves less heart-focused potency than citrate, glycinate, or malate products with larger amounts.

Study evidence
Magnesium Supportive 158 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B Goal FitC+ Strength of SupportF CoverageA- Formula Quality
Magnesium · 2000 mg

Magnesium supports vascular tone and normal cardiac rhythm, giving the mineral direct cardiovascular relevance. The L-threonate form is designed mainly for nervous-system delivery rather than providing a large magnesium amount.

Only 145 mg of elemental magnesium is supplied from three capsules, which is modest for targeted cardiovascular use. Form and elemental yield are clearly disclosed, but the product covers no lipid, endothelial, or cardiac-energy pathway.

Study evidence
Magnesium Supportive 123 studies
Testosterone Support
Testosterone Support
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportD CoverageB+ Formula Quality
Magnesium · 2000 mg

Magnesium L-threonate provides a well-defined, bioavailable form that may support endocrine function when magnesium status is low. The 145 mg elemental amount is modest for a goal that often benefits from fuller magnesium repletion.

The focused formula avoids unrelated ingredients and clearly separates elemental magnesium from the 2,000 mg compound amount. Its main strength is form quality, while narrow pathway coverage and the lower elemental dose limit testosterone support.

Study evidence
Magnesium Disputed 5 studies

Ingredients

IngredientAmount per serving
Magnesium (Magnesium L-Threonate)
 145 mg
Magnesium L-Threonate
2000 mg
Adults 18–50
Report overview
Magnesium (Magnesium L-Threonate) · 145 mg OverallScore74
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD+ Value

Magnesium L-threonate provides a premium form at the studied elemental yield. The 145 mg elemental amount aligns with the studied L-threonate yield. The serving is costly, and the supplied label does not identify a patented Magtein source.

View ingredientView products
Loading alternative details
85 Performance

Cal/Mag 500 mg/250 mg

NaturesPlus
A more purposeful active profile is better aligned with the original’s main use because chelated calcium and magnesium provide a focused, balanced mineral formula with strong form quality. A simple one-serving format and economical cost make it one of the better value profiles in this set.
85 Performance

Magnesium Bisglycinate 200 mg

Natural Factors
A more purposeful active profile is better aligned with the original’s main use because a focused magnesium bisglycinate powder uses a highly absorbable form at a moderate, practical amount. Strong aggregate satisfaction and reasonable serving economics support value without an aggressive dose.
85 Performance

Magnesium Bisglycinate Chelate

Healthy Origins
A more purposeful active profile is better aligned with the original’s main use because tRAACS magnesium bisglycinate provides premium absorption quality, a useful elemental amount, and exceptional serving value in a clean powder. The product is narrow rather than comprehensive, and its relatively weak satisfaction metric deserves consideration despite the strong formula.
83 Budget

Magnesium Citrate Pure Powder

Best Naturals
Lower serving cost makes it the more economical option, while a well-aligned amount of magnesium citrate delivers useful absorption in a focused powder. The simple formula and very low serving cost provide strong value, with digestive tolerance as the main practical uncertainty.
91 Budget

Krebs Magnesium Potassium Complex

Nature's Way
Lower serving cost makes it the more economical option, while magnesium lysinate and malate provide favorable forms at a useful amount, with a modest potassium contribution. The focused formula offers excellent serving value.
88 Budget

Magnesium Bisglycinate Powder

NOW
Lower serving cost makes it the more economical option, while magnesium bisglycinate supplies a well-absorbed form at a practical, moderate amount. The pure powder is adjustable, clearly labeled, and inexpensive, supporting strong routine value.
84 Value

Potassium + Magnesium

Nutricost
Ingredient quality and serving value are better balanced here because a meaningful magnesium citrate amount anchors a simple two-mineral electrolyte formula. Potassium is modest, but the focused design and very low serving cost support excellent everyday value.
83 Value

Magnesium Citrate 200 mg

Best Naturals
Ingredient quality and serving value are better balanced here because a substantial amount of magnesium citrate combines useful absorption with a focused single-active design. Digestive sensitivity is the main trade-off, while the low serving cost supports strong practical value.
80 Value

Magnesium Caps 500 mg

Life Extension
Ingredient quality and serving value are better balanced here because citrate, succinate, and a named glycinate chelate strengthen a multi-form magnesium blend, while oxide lowers average absorption. The large supplemental amount may cause diarrhea or cramping, although the very low serving cost provides strong value for users who tolerate it.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  2. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  3. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  4. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.
    Kubota M; Ito K; Tomimoto K; Kanazaki M; Tsukiyama K; Kubota A; Kuroki H; Fujita M; Vandenplas Y · Nutrients · 2020
    Randomized trial60 participantsDigestive Health forMagnesium
  5. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  6. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  7. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  8. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  9. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  10. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  11. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  12. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  13. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  14. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  15. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  16. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  17. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  18. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  19. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  20. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  21. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  22. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  23. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  24. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  25. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  26. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  27. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  28. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  29. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  30. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  31. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  32. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  33. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  34. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  35. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  36. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium