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Magnesium Malate

4.8
★ ★ ★ ★ ★
(21794 ratings)
Magnesium 425 mg
Product Image
Score79
A long-supply magnesium malate tablet offers good form quality and value, though the full dose is high and requires three tablets.
How scoring works
Quantity:360 Tablet(s) • (120 servings)
Goals:
Energy
General Health
Stress Relief
Heart Health
Cardiovascular Support
Bone Health
Testosterone Support
Digestive Health

Score 79

A long-supply magnesium malate tablet offers good form quality and value, though the full dose is high and requires three tablets.
How scoring works
$29.38($0.24 per serving)
iHerb
$ 35.69
Vitacost
$ 34.65
Amazon
$ 29.38
Walmart
$ 34.65
Vitacost
$ 34.65
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Analysis

The serving provides 425 mg of elemental magnesium from malate trihydrate with 2.5 g of malic acid. Clear separation of elemental and compound amounts makes the label easier to interpret.

Malate offers better systemic absorption than oxide and the larger bottle reduces repurchasing frequency. Three tablets and added carbohydrate make each serving bulky.

Regular malate users who want a long supply are the strongest fit. People needing only modest maintenance can lower pill burden and digestive risk with a smaller dose.

Who is it for
  • Long-term magnesium malate users
  • Adults comfortable with multi-tablet servings
  • People seeking a high elemental amount
Best for
  • Extended-supply malate use
  • Systemic magnesium support
  • Value over a larger package

Pros

  • Uses an absorbed malate form
  • Clearly states elemental magnesium
  • Large 120-serving supply
  • Good long-term value

Cons

  • 425 mg is a substantial serving
  • Three-tablet pill burden
  • Adds 3 g of carbohydrate
  • No patented malate source

Warnings

  • The 425 mg serving of supplemental magnesium may cause loose stools, cramping, or nausea; a smaller divided amount may be easier to tolerate.
  • Magnesium can reduce absorption of tetracycline or quinolone antibiotics; follow the prescriber or pharmacist’s spacing instructions.
  • Magnesium can interfere with levothyroxine absorption and should be separated according to medication guidance.
  • People with significantly reduced kidney function can accumulate magnesium and need clinician-guided use.

Nutrient quality

82 Highest impact

Magnesium malate provides strong absorption potential and a relevant organic-acid carrier. The elemental amount is substantial and near the upper end of routine daily use, while the larger amount may loosen stools or cause discomfort in sensitive users.

Ingredient transparency

74 High impact

Elemental and compound amounts are disclosed, though repeated entries make the presentation harder to read. Serving totals are apparent, but full directions and inactive ingredients are not supplied.

Customer satisfaction

72 High impact

The supplied average rating is strong. The exceptionally large rating base makes the average highly stable, while complaint and firsthand experience details are unavailable.

Value for money

86 Highest impact

Formula quality supports the asking position well. The serving value is highly competitive within the category.

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Goals

Energy
Impact
Highest effect
A- Goal FitA Strength of SupportC+ CoverageA- Formula Quality
Magnesium · 3.75 Gram(s)

Magnesium malate combines an essential ATP cofactor with malate, an intermediate used in cellular energy pathways. The highly absorbable form and substantial elemental amount give the product strong energy relevance.

Clear disclosure supports confidence in the active delivery, although the serving sits near the upper end of common supplemental use. The high magnesium and malate load may cause digestive discomfort in sensitive users.

Study evidence
Magnesium Supportive 4 studies
General Health
Impact
Highest effect
B+ Goal FitA- Strength of SupportC CoverageA Formula Quality
Magnesium · 3.75 Gram(s)

Magnesium malate provides focused support for normal muscle, nerve, and energy-related functions. Clear separation of elemental magnesium from compound weight improves label transparency.

The narrow formula does not cover broader vitamin or fatty-acid needs. A 425 mg magnesium serving may cause loose stools or abdominal discomfort in sensitive users.

Study evidence
Magnesium Supportive 114 studies
Stress Relief
Impact
Highest effect
C+ Goal FitA Strength of SupportC+ CoverageA+ Formula Quality
Magnesium · 3.75 Gram(s)

Magnesium malate supplies 425 mg of magnesium for foundational nervous-system and muscle support. Stress relief is most likely when low magnesium status contributes to tension, so the effect is supportive rather than directly adaptogenic.

Magnesium malate is a reasonably bioavailable form with a clearly stated elemental amount. 425 mg of supplemental magnesium may cause loose stools or abdominal discomfort in sensitive users.

Study evidence
Magnesium Supportive 13 studies
Heart Health
Impact
High effect
B Goal FitB+ Strength of SupportC CoverageA+ Formula Quality
Magnesium · 3.75 Gram(s)

Magnesium supports normal heart rhythm and vascular tone when intake is inadequate. The 425 mg amount is clearly stated as magnesium malate.

The high supplemental amount may cause diarrhea or abdominal discomfort in sensitive users. The focused formula does not address lipid or cardiac-energy pathways.

Study evidence
Magnesium Supportive 158 studies
Cardiovascular Support
Impact
High effect
B Goal FitA- Strength of SupportD+ CoverageB+ Formula Quality
Magnesium · 3.75 Gram(s)

Magnesium supports vascular relaxation and normal electrical rhythm, giving this focused supplement a clear cardiovascular role. Magnesium malate is a well-absorbed organic form, although the label repeats compound and malic-acid amounts.

The single-mineral approach does not address lipids, endothelial nitric oxide, or antioxidant protection. The 425 mg amount may cause loose stools in sensitive users.

Study evidence
Magnesium Supportive 123 studies
Bone Health
Impact
High effect
B- Goal FitA- Strength of SupportD CoverageB+ Formula Quality
Magnesium · 3.75 Gram(s)

Magnesium malate offers a favorable absorbed form and a substantial elemental amount. It supports an important bone cofactor pathway but leaves calcium supply, vitamin D, vitamin K, and collagen unaddressed.

Clear elemental disclosure makes the dose easy to assess. The amount may cause digestive upset or loose stools in sensitive users.

Study evidence
Magnesium Supportive 48 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Total Carbohydrates
3 Gram(s)
Magnesium (Magnesium Malate Trihydrate)
425 mg
Sodium
5 mg
Magnesium Malate Trihydrate
3.75 Gram(s)
Malic Acid (Magnesium Malate Trihydrate)
2.5 Gram(s)
Adults 18–50
Report overview
B- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyA+ Value

Magnesium malate offers a highly bioavailable form with clearly stated elemental content. The 425 mg serving sits just above the configured therapeutic range but remains below the level associated with a stronger digestive-tolerance penalty. A low serving cost supports strong value, although no patented chelation standard or supportive cofactor is identified.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  2. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  3. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  4. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation.
    Bu LN; Chang MH; Ni YH; Chen HL; Cheng CC · Pediatrics international : official journal of the Japan Pediatric Society · 2007
    Randomized trial45 participantsDigestive Health forMagnesium
  5. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.
    Kubota M; Ito K; Tomimoto K; Kanazaki M; Tsukiyama K; Kubota A; Kuroki H; Fujita M; Vandenplas Y · Nutrients · 2020
    Randomized trial60 participantsDigestive Health forMagnesium
  6. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  7. Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial.
    Yoneda H; Tomita T; Kitano T; Morishita D; Kodani M; Nishii N; Sei H; Eda H; Sato T; Kawai M; Yokoyama Y; Igeta M; Okugawa T; Fukui H; Shinzaki S · Neurogastroenterology and motility · 2026
    Randomized trial40 participantsDigestive Health forMagnesium
  8. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  9. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  10. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  11. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  12. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  13. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  14. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  15. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  16. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  17. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  18. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  19. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  20. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  21. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  22. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  23. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  24. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  25. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  26. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  27. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  28. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  29. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  30. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  31. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  32. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  33. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  34. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  35. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  36. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  37. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  38. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  39. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  40. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  41. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  42. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  43. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium