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B-100 Gels

Carlson
4.8
★ ★ ★ ★ ★
(266 ratings)
Niacin 100 mg
Thiamin 100 mg
Riboflavin 100 mg
Vitamin B5 100 mg
Vitamin B6 100 mg
Choline 13 mg
Product Image
Score66
The B-100 profile is complete but unnecessarily aggressive for ordinary use. High pyridoxine, large folate exposure, and conventional forms outweigh the breadth.
How scoring works
Quantity:200 Softgel(s) • (100 servings)
Goals:
Energy
Metabolism Boost

Score 66

The B-100 profile is complete but unnecessarily aggressive for ordinary use. High pyridoxine, large folate exposure, and conventional forms outweigh the breadth.
How scoring works

Also available as

3 options
50 mg • 200 Softgel(s) servings 50 mg • 200 Softgel(s) • 200 servings $48.37 ($0.24 per serving) 50 mg • 50 Softgel(s) servings 50 mg • 50 Softgel(s) • 50 servings $14.37 ($0.28 per serving) 100 servings 2 Softgel(s) • 100 Softgel(s) • 50 servings $23.38 ($0.46 per serving)
$43.52($0.43 per serving)
iHerb
$ 43.52
iHerb
$ 43.52
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Analysis

The two-softgel serving provides thiamine, riboflavin, niacinamide, B6, B12, biotin, and pantothenic acid near the 100-level pattern, with a large folate amount as well. Phosphatidylcholine adds a small choline contribution.

Most forms are conventional, including thiamine mononitrate, pyridoxine hydrochloride, and cyanocobalamin. The large doses therefore do not come with a corresponding improvement in form quality.

Vitamin B6 at 100 mg is the main concern because prolonged daily use can cause nerve symptoms. This is an aggressive formula for a defined, supervised need rather than a sensible everyday energy supplement.

Who is it for
  • Adults with a clinician-defined need for high-potency B vitamins
  • Short-term users who require a B-100 profile
  • People able to avoid other B6 sources
Best for
  • Supervised high-potency supplementation
  • Short-duration B-vitamin repletion
  • Broad B-100 coverage

Pros

  • Provides every core B vitamin
  • Includes phosphatidylcholine
  • Uses niacinamide
  • Clearly states the main nutrient amounts

Cons

  • Contains 100 mg of vitamin B6
  • Uses pyridoxine and cyanocobalamin
  • Folate exposure is high
  • Requires two soy-containing softgels

Warnings

  • The 100 mg vitamin B6 amount may cause tingling, numbness, balance problems, or other nerve symptoms with prolonged use.
  • Soy-derived phosphatidylcholine makes it unsuitable for people with a soy allergy.
  • Do not combine it with other B6 or high-folate supplements unless total intake is clinically managed.

Nutrient quality

56 Moderate impact

The formula relies on thiamine mononitrate, pyridoxine hydrochloride, cyanocobalamin, and conventional forms. The very high vitamin B6 amount creates a substantial neuropathy concern with long-term use.

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Ingredient transparency

87 Highest impact

Specific amounts are supplied for every listed active ingredient. No proprietary blend hides the listed doses.

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Customer satisfaction

70 High impact

The supplied aggregate rating is very strong. No complaint themes or purpose-specific experience details are supplied.

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Value for money

46 Lower impact

Major dose, transparency, or formulation weaknesses make the qualitative cost difficult to justify. Phosphatidylcholine is relevant, while softgel fat and protein add little active value.

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Report analysis

Goals

Energy
Energy
Impact
High effect
B Goal FitC- Strength of SupportC- CoverageB+ Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

High amounts of thiamin, riboflavin, niacin, vitamin B6, and pantothenic acid provide broad B-vitamin support for energy metabolism. The focused formula avoids unrelated botanical blends.

Vitamin B12 remains below the rubric's higher target and uses cyanocobalamin, while most other forms are conventional. The very high vitamin B6 amount may raise the risk of nerve symptoms with prolonged daily use.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Metabolism Boost
Metabolism Boost
Impact
Moderate effect
D+ Goal FitC Strength of SupportD+ CoverageB+ Formula Quality
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

High-potency B vitamins support cellular energy reactions but do not directly increase thermogenesis or fat oxidation. The formula is most relevant for correcting low intake rather than boosting an already adequate metabolism.

Conventional vitamin forms limit quality compared with an active coenzyme B-complex. The 100 mg B6 amount reaches a chronic-use concern and may increase nerve-symptom risk with prolonged daily use.

Study evidence
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Fat
1.5 Gram(s)
Protein
1 Gram(s)
Thiamine (Thiamine Mononitrate, Vitamin B1)
 100 mg
Riboflavin (Vitamin B2)
 100 mg
Niacin (Niacinamide)
 100 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Folate
1360 mcg DFE
Vitamin B-12 (Cyanocobalamin)
 100 mcg
Biotin
100 mcg
Pantothenic Acid (Calcium D-Pantothenate)
 100 mg
Choline (Phosphatidylcholine)
 13 mg
Phosphatidyl Choline (Soybeans)
 100 mg
Gluten Free Adults 18–50 Women
Report overview
Niacin (Niacinamide) · 100 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value

Niacinamide is clearly disclosed at an amount suited to targeted general use. The swallowed softgel provides conventional immediate delivery without added release technology. Its broad B-complex profile offers moderate context for a serving cost that remains high for standard niacinamide.

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Thiamin (Thiamine Mononitrate, Vitamin B1) · 100 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

The 100 mg thiamine amount is potent and clearly disclosed, but thiamine mononitrate remains a conventional form. Softgel delivery offers no stated absorption advantage, and the cost per active dose is high for standard thiamine. The 100 mg vitamin B6 amount may raise the risk of nerve symptoms with prolonged daily use.

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Riboflavin (Vitamin B2) · 100 mg OverallScore74
D- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Standard riboflavin requires conversion before it becomes active. The 100 mg dose supplies a high-potency amount for metabolic support. The useful dose is offered at a competitive serving cost.

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Loading alternative details
79 Performance

B Complex Plus

Seeking Health
<p>It improves ingredient-form quality through active riboflavin, vitamin B6, and vitamin B12 forms at meaningful amounts. The niacin declaration is ambiguous and may carry flushing potential.</p>
80 Performance

B-Complex #12

Thorne
<p>It improves ingredient-form quality through a focused B-complex with methylcobalamin and substantial energy-metabolism coverage. Several forms are not identified, and vitamin B6 and niacin warrant attention alongside fortified foods or other supplements.</p>
80 Performance

B-100 Complex with B2 Coenzyme

Nature's Way
<p>It improves ingredient-form quality through active riboflavin and partial P-5-P within broad B-vitamin coverage. The total vitamin B6 amount is very high and may raise nerve-symptom risk with prolonged use.</p>
77 Budget

B-50

NOW
<p>It lowers the recurring cost while providing broad B-vitamin dosing and a large supply. Basic forms and high vitamin B6 reduce suitability for indefinite daily use.</p>
74 Budget

B-Complex '50'

Solgar
<p>It lowers the recurring cost while providing complete B-vitamin coverage aligned with energy metabolism. Conventional forms, high vitamin B6, and a tiny herbal blend limit the quality case.</p>
77 Budget

B-50 Complex 50 mg

Source Naturals
<p>It lowers the recurring cost while providing broad metabolic coverage with clearly stated amounts and substantial pantothenic acid. High folic acid and vitamin B6 reduce dose balance for routine use.</p>
77 Value

B-50 Complex

Nature's Way
<p>It balances formulation quality and cost through active riboflavin and a broad, clearly dosed B-complex base. Vitamin B6 remains unnecessarily high for routine long-term use.</p>
76 Value

Hi Potency B Complex

Natural Factors
<p>It balances formulation quality and cost through a complete high-potency B-vitamin pattern with coherent energy support. High folate and vitamin B6 make the formula unnecessarily aggressive for unsupervised daily use.</p>
75 Value

B-Complex 50

Bluebonnet
<p>It balances formulation quality and cost through a complete B-vitamin pattern with clear amounts and reasonable serving value. The formula still relies on basic forms and a high vitamin B6 amount.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  2. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  3. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  4. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
    González-Domínguez R; Castellano-Escuder P; Lefèvre-Arbogast S; Low DY; Du Preez A; Ruigrok SR; Lee H; Helmer C; Pallàs M; Urpi-Sarda M; Sánchez-Pla A; Korosi A; Lucassen PJ; Aigner L; Manach C; Thuret S; Samieri C; Andres-Lacueva C · Alzheimer's research & therapy · 2022
    Observational studyMetabolism Boost forVitamin B5
  5. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  6. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  7. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  8. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  9. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  10. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  11. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  12. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  13. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  14. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  15. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  16. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  17. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  18. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  19. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6