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Sleep Support

The Vitamin Shoppe
4.5
★ ★ ★ ★ ★
(29 ratings)
Theanine 200 mg
GABA 250 mg
Valerian 300 mg
5-HTP 250 mg
Product Image
Score77
Meaningful theanine, GABA, 5-HTP, and melatonin create strong bedtime support. High-dose 5-HTP and additive sedation make medication screening and cautious use essential.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Sleep Support
Stress Relief
Mood Support

Score 77

Meaningful theanine, GABA, 5-HTP, and melatonin create strong bedtime support. High-dose 5-HTP and additive sedation make medication screening and cautious use essential.
How scoring works
$21.99($0.73 per serving)
iHerb
$ 21.99
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Analysis

L-theanine at 200 mg and GABA at 250 mg provide meaningful calming amounts, while 2 mg melatonin supports sleep timing. Valerian is supplied as 300 mg raw root powder, which is less concentrated and below a stronger nighttime range.

5-HTP from Griffonia is listed at 250 mg, a relatively high amount for a combined sleep formula. Its source is named, but active standardization and a gradual-release feature are not disclosed.

Two capsules and clear individual amounts are practical. The product fits adults who specifically need a strong bedtime combination and have no serotonergic medicine conflict.

Who is it for
  • Adults seeking nighttime sleep support
  • People who want several calming pathways in one formula
  • Users not taking serotonin-raising medicines
Best for
  • Bedtime relaxation
  • Sleep-onset support
  • Strong multi-pathway bedtime calming

Pros

  • Provides 200 mg L-theanine
  • Supplies 250 mg GABA
  • Uses a moderate 2 mg melatonin amount
  • Clearly discloses all active amounts

Cons

  • 5-HTP is relatively high at 250 mg
  • Valerian is unstandardized root powder
  • Valerian amount is modest for raw powder
  • Poor fit for daytime cognitive goals

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines because serotonin effects can become excessive.
  • The combined sleep ingredients can cause substantial drowsiness; do not drive after use.
  • Alcohol, sedatives, and other sleep medicines can intensify the formula’s effects.

Nutrient quality

80 High impact

L-theanine is appropriate, but raw valerian powder and unstandardized Griffonia reduce technical quality; theanine, GABA, and melatonin are useful, while the 5-HTP amount is comparatively high. The high 5-HTP amount and combined sedatives create avoidable interaction and drowsiness concerns; the actives strongly fit sleep and relaxation support; every listed active has a plausible role in the nighttime formula.

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Ingredient transparency

77 High impact

Every listed active has a specific amount; no proprietary blend hides key doses. Names and sources are mostly clear, though active standardization is not provided for Griffonia or valerian; serving directions and inactive ingredients are not included in the supplied details.

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Customer satisfaction

62 Moderate impact

The supplied aggregate average is favorable, though no individual feedback is available; the small rating sample limits confidence, and no individual feedback is supplied. Detailed feedback is absent, so repeated complaints cannot be assessed; real-world fit with the intended purpose remains uncertain.

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Value for money

86 Highest impact

Meaningful dosing supports good value despite ordinary ingredient forms; the serving supplies several useful actives at a reasonable cost. The formula avoids obvious low-value extras; it compares well with similarly broad sleep blends.

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Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A- Goal FitA- Strength of SupportA- CoverageB Formula Quality
Melatonin · 2 mgTheanine · 200 mg

Melatonin, theanine, GABA, valerian, and 5-HTP address circadian timing and several relaxation pathways. The formula is strongly sleep focused but combines potent mechanisms that may not suit everyone.

Theanine, GABA, and melatonin have meaningful amounts, while valerian is modest and 5-HTP is relatively high. 5-HTP can dangerously compound serotonergic medicines such as SSRIs or MAO inhibitors.

Study evidence
5-HTP Supportive 1 study
GABA Supportive 4 studies
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Valerian Supportive 31 studies
Stress Relief
Stress Relief
Impact
Highest effect
A- Goal FitB+ Strength of SupportB+ CoverageB+ Formula Quality
GABA · 250 mgTheanine · 200 mg

L-theanine, GABA, valerian, 5-HTP, and melatonin provide strong nighttime calming and sleep support. The formula is aimed at stress-related sleep difficulty rather than daytime resilience and may cause substantial drowsiness.

Theanine and GABA reach useful amounts, while valerian root powder is modest and 5-HTP is unusually high. The 5-HTP may dangerously compound serotonergic medicines such as selective serotonin reuptake inhibitors or monoamine oxidase inhibitors, and the sedative blend should not be used before driving.

Study evidence
5-HTP Supportive 18 studies
GABA Supportive 6 studies
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Valerian Supportive 18 studies
Mood Support
Mood Support
Impact
High effect
B Goal FitC+ Strength of SupportB- CoverageA- Formula Quality
5-HTP · 250 mg

5-HTP supports serotonin production, while L-theanine, GABA, valerian, and melatonin promote nighttime calm and sleep. The formula is more sedating than broadly mood stabilizing, and the 5-HTP amount is higher than the preferred range.

The combination has a clear nighttime purpose, but several generic forms lack standardization or branded quality details. Combining 5-HTP with SSRIs or MAO inhibitors can dangerously raise serotonin, and the sleep actives can impair alertness.

Study evidence
5-HTP Supportive 9 studies
GABA Supportive 12 studies
Theanine Supportive 12 studies
Valerian Supportive 17 studies
Brain Health
Brain Health
Impact
Moderate effect
C- Goal FitB Strength of SupportD CoverageC Formula Quality

The formula is primarily a sleep aid rather than a direct daytime brain-health product. L-theanine is meaningfully dosed, while melatonin, valerian, GABA, and 5-HTP reinforce sedation and nighttime use.

Its calming ingredients may indirectly help cognition through sleep, but they do not provide broad neuronal or memory support. The 5-HTP amount may dangerously compound serotonergic medicines such as SSRIs or MAO inhibitors, and the blend can cause drowsiness.

Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Productivity Boost
Productivity Boost
Impact
Moderate effect
D- Goal FitB+ Strength of SupportD+ CoverageD Formula Quality
Theanine · 200 mg

L-theanine may promote calm attention, while sleep support can indirectly help next-day function. The theanine amount is well aligned with common use.

Valerian, GABA, melatonin, and 5-HTP make this a sedating bedtime formula rather than a daytime productivity aid. The 5-HTP may dangerously compound serotonergic medicines such as SSRIs, SNRIs, or MAO inhibitors, and the blend may cause drowsiness.

Study evidence
Theanine Supportive 5 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
D Goal FitB+ Strength of SupportD+ CoverageD- Formula Quality
Theanine · 200 mg

L-theanine can support calm focus, but valerian, GABA, 5-HTP, and melatonin make the formula strongly sleep oriented. The combined effect is likely to reduce alertness rather than support active cognitive work.

5-HTP can interact dangerously with serotonergic medicines such as SSRIs or MAO inhibitors. The complete blend may cause drowsiness and should not be used before driving or other alertness-dependent tasks.

Study evidence
Theanine Supportive 25 studies
Mental Focus
Mental Focus
Impact
Moderate effect
C- Goal FitB- Strength of SupportD CoverageD+ Formula Quality
Theanine · 200 mg

L-theanine may support calm attention, but 5-HTP and the broader sleep design favor sedation rather than daytime focus. The formula is therefore poorly aligned with sustained alertness.

The 200 mg L-theanine amount is useful and clear, while source purity is not documented. The 250 mg 5-HTP may compound serotonergic medicines such as SSRIs or MAO inhibitors, and the blend may cause drowsiness.

Study evidence
Theanine Supportive 19 studies

Ingredients

IngredientAmount per serving
Valerian root powder
300 mg
L-Theanine
200 mg
GABA
250 mg
5-HTP (Griffonia Seed Extract)
 250 mg
Melatonin
2 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Theanine · 200 mg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

A clearly disclosed 200 mg L-theanine amount sits in the preferred range, though the generic source lacks purity evidence. Value is strengthened by the additional 250 mg 5-HTP dose. The 5-HTP may dangerously compound serotonergic medicines such as SSRIs or MAO inhibitors, and the sleep blend may also cause drowsiness.

View ingredientView products
GABA · 250 mg OverallScore72
B- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD- Value

The GABA amount reaches the preferred effective range within a multi-ingredient sleep formula. A standard capsule and unbranded source provide acceptable quality without a premium delivery advantage. The serving cost is high for standard GABA. Included 5-HTP can raise serotonin and may conflict with medicines such as selective serotonin reuptake inhibitors or monoamine oxidase inhibitors.

View ingredientView products
Valerian · 300 mg OverallScore57
C- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyD- Value

Raw root powder offers no concentrated or standardized potency advantage. The 300 mg root amount is below the preferred range for stronger nighttime support. The higher cost is difficult to justify for an under-target raw powder.

View ingredientView products
Loading alternative details
76 Performance

Best-Rest Formula

Pure Encapsulations
<p>Branded L-theanine, active vitamin B6, substantial GABA, valerian, and several calming herbs create a technically strong sleep blend. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
77 Performance

Lights Out Sleep

ALLMAX
<p>A varied sleep blend provides useful valerian, GABA, melatonin, and active vitamin B6. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
75 Performance

Ortho Sleep

AOR Advanced Orthomolecular Research Advanced
<p>A broad mix of sleep ingredients offers strong pathway coverage with clearly disclosed amounts. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
78 Budget

Sleep

NOW
<p>Substantial valerian, hops, passionflower, and GABA create a focused nighttime calming blend. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
75 Budget

5-HTP 100 mg

Solgar
<p>A full 5-HTP amount is supported by active vitamin B6, magnesium, and valerian for mood and sleep-related use. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
71 Budget

PM Formula

Nature's Way
<p>Valerian, hops, theanine, and black cohosh form a coherent nighttime relaxation formula. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
83 Value

ZenMind

NutriCology
<p>Branded L-theanine and a substantial GABA amount form a focused relaxation stack with fully disclosed doses. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
74 Value

Chewable GABA

NOW
<p>A substantial GABA amount anchors the calming chewable, while taurine, inositol, and L-theanine provide only modest support. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
69 Value

Sleep Support

Bluebonnet Targeted Choice
<p>Theanine, valerian, tart cherry, passionflower, 5-HTP, and chamomile form a coherent but lightly dosed sleep blend. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  2. Does valerian work for insomnia? An umbrella review of the evidence.
    Valente V; Machado D; Jorge S; Drake CL; Marques DR · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
    Systematic review8 studies pooledSleep Support forValerian
  3. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  4. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  5. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  6. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsSleep Support Brain Health Cognitive Support forTheanine
  7. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  8. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  9. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsStress Relief Sleep Support forGABA
  10. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsStress Relief Mood Support forTheanine
  11. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  12. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  13. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  14. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  15. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  16. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  17. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  18. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  19. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  20. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  21. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  22. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  23. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  24. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  25. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  26. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  27. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  28. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  29. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  30. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  31. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  32. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  33. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  34. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  35. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  36. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine Stress Relief forGABA
  37. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  38. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsMood Support Sleep Support Stress Relief forValerian
  39. Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
    Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
    Meta-analysis12 studies pooledMood Support forValerian
  40. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
    Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
    Meta-analysis6,894 participants60 studies pooledMood Support forValerian
  41. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
    Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
    Randomized trial20 participantsMood Support forValerian
  42. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledMood Support Stress Relief forValerian
  43. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  44. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  45. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost forTheanine
  46. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  47. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  48. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  49. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  50. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  51. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  52. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  53. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  54. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
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  55. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  56. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
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    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
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    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
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    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
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    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
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    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
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    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  64. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  65. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
    Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
    Randomized trial202 participantsStress Relief forMelatonin
  66. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
    Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
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  67. Melatonin for pre- and postoperative anxiety in adults.
    Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
    Meta-analysis774 participants12 studies pooledStress Relief forMelatonin
  68. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
    Meta-analysis441 participants5 studies pooledStress Relief forMelatonin
  69. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
    Randomized trial88 participantsStress Relief forMelatonin
  70. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  71. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
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    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
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    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian