Product Image

Totally Zen

Carlson
4.7
★ ★ ★ ★ ★
(461 ratings)
Theanine 100 mg
Vitamin B6 25 mg
GABA 200 mg
Thiamin 10 mg
Niacin 25 mg
Riboflavin 10 mg
Product Image
Score74
A transparent calming formula combines theanine and GABA with broad nutrient support. The short supply, conventional forms, and elevated B6 reduce its appeal for ongoing use.
How scoring works
Quantity:30 Capsule(s) • (30 servings)
Goals:
Stress Relief
Productivity Boost
Mental Focus
Cognitive Support
Mood Support
Brain Health

Score 74

A transparent calming formula combines theanine and GABA with broad nutrient support. The short supply, conventional forms, and elevated B6 reduce its appeal for ongoing use.
How scoring works

Also available as

1 option
120 servings 1 Capsule(s) • 120 Capsule(s) • 120 servings $29.67 ($0.24 per serving)
$8.42($0.28 per serving)
iHerb
$ 8.42
Report prices

Analysis

L-theanine and GABA anchor the formula with complementary calm-focus and relaxation roles. Their amounts are clearly stated but remain moderate rather than intensive.

The B-complex and magnesium provide broader nutritional coverage. Magnesium oxide, cyanocobalamin, and pyridoxine are serviceable but less appealing than better-absorbed or active alternatives.

The smaller container can suit someone who wants to test tolerance before buying a long supply. Daily use still deserves caution because the B6 amount is high enough to become relevant over time.

Who is it for
  • Adults trialing a calm-focus supplement
  • Users seeking theanine plus GABA
  • People who prefer capsules
Best for
  • Short-term trial use
  • Mild daytime calming support
  • Broad B-vitamin coverage

Pros

  • Clear active-ingredient amounts
  • Balanced theanine and GABA pairing
  • Includes magnesium and B vitamins
  • Small container supports a low-commitment trial

Cons

  • Only a short supply
  • Magnesium includes the oxide form
  • Theanine and GABA amounts are modest
  • Several vitamins use conventional forms

Warnings

  • Daily 25 mg vitamin B6 may increase the risk of tingling or numbness with prolonged use, particularly with other B6 supplements.
  • Magnesium oxide may cause loose stools or cramping in sensitive users.
  • GABA and theanine may cause drowsiness; assess tolerance before driving or combining with sedating products.

Nutrient quality

66 High impact

Theanine, GABA, and magnesium align well with relaxation, although their amounts are moderate. Mixed magnesium quality and relatively high vitamin B6 reduce the formula balance.

Ingredient transparency

79 High impact

All listed actives have amounts and no proprietary blend obscures them. Daily directions and inactive ingredients are not available in the supplied details.

Customer satisfaction

70 High impact

The strong rating is supported by a substantial review base. Absent review text prevents assessment of repeated complaints or calming experiences.

Value for money

81 Highest impact

A low serving cost and useful calming core support good value. Ordinary vitamin forms and modest magnesium keep the formula from standing out on quality.

Report analysis

Goals

Stress Relief
Stress Relief
Impact
Highest effect
A- Goal FitB Strength of SupportA- CoverageA- Formula Quality
Magnesium · 50 mgFolate · 340 mcg DFEVitamin B12 · 50 mcgGABA · 200 mgVitamin B6 · 25 mgVitamin C · 90 mgTheanine · 100 mg

L-theanine and GABA provide direct calming support, while magnesium and B vitamins broaden nervous-system and metabolic resilience. The formula is well aligned with acute and background stress without relying on a sedative herb.

L-theanine reaches an effective amount and GABA is suitable for a blend, though magnesium is low and partly supplied as oxide. Vitamin B6 is substantial but uses pyridoxine rather than the active P-5-P form.

Study evidence
GABA Supportive 6 studies
Magnesium Supportive 13 studies
Theanine Supportive 16 studies
Vitamin B6 Supportive 10 studies
Productivity Boost
Productivity Boost
Impact
High effect
B+ Goal FitB Strength of SupportB CoverageB- Formula Quality
Vitamin B12 · 50 mcgVitamin B12 · 50 mcgVitamin B6 · 25 mgMagnesium · 50 mgTheanine · 100 mg

L-theanine supports calm attention, while B vitamins and magnesium provide broader metabolic and neurotransmitter support. GABA may contribute to relaxation, but its direct cognitive effect is less certain.

The 100 mg theanine amount reaches a useful starting level, and all active amounts are disclosed. Broad vitamin coverage, generic forms, magnesium oxide, and several overlapping calming ingredients make the formula less precise than a focused productivity stack.

Study evidence
Magnesium Supportive 10 studies
Theanine Supportive 5 studies
Mental Focus
Mental Focus
Impact
High effect
B+ Goal FitB Strength of SupportB- CoverageB- Formula Quality
Folate · 340 mcg DFEVitamin B6 · 25 mgVitamin B12 · 50 mcgMagnesium · 50 mgTheanine · 100 mg

L-theanine, vitamin B6, and GABA create a calm-focus formula with useful disclosed amounts. Theanine reaches a meaningful starting dose, while B6 uses pyridoxine rather than the preferred active P-5-P form.

The broad B-vitamin base supports neurotransmitter metabolism but may be more extensive than needed for acute focus. No stimulant is present, so the effect should favor reduced tension over strong alertness.

Study evidence
Magnesium Supportive 6 studies
Theanine Supportive 19 studies
Vitamin B6 Disputed 6 studies
Cognitive Support
Cognitive Support
Impact
High effect
B- Goal FitB- Strength of SupportB CoverageB Formula Quality
Thiamin · 10 mgVitamin B6 · 25 mgFolate · 340 mcg DFEVitamin B12 · 50 mcgMagnesium · 50 mgTheanine · 100 mg

L-theanine, GABA, magnesium, and B vitamins create a broad calm-focus and neurotransmitter-support formula. L-theanine and vitamin B6 are meaningfully dosed, while magnesium is modest, GABA has limited brain access, and several nutrient forms are not preferred.

The ingredients generally share a coherent nervous-system purpose, but the vitamin-heavy design is less targeted to memory or long-term brain structure. Full dose disclosure is a strength, while the broad list introduces some lower-value padding.

Study evidence
Magnesium Supportive 24 studies
Theanine Supportive 25 studies
Vitamin B6 Supportive 17 studies
Mood Support
Mood Support
Impact
High effect
B- Goal FitC+ Strength of SupportB- CoverageA- Formula Quality
Folate · 340 mcg DFEVitamin B6 · 25 mgVitamin B12 · 50 mcgMagnesium · 50 mg

L-theanine and GABA provide direct calming support, while B vitamins and magnesium add foundational nervous-system nutrition. The formula may be most useful for tension-related mood symptoms rather than broader mood regulation.

L-theanine is well dosed, but magnesium is modest and several vitamin forms are less preferred. The combined calming ingredients are coherent, although GABA may cause drowsiness in sensitive users.

Study evidence
GABA Supportive 12 studies
Magnesium Supportive 60 studies
Theanine Supportive 12 studies
Brain Health
Brain Health
Impact
High effect
B- Goal FitC+ Strength of SupportC+ CoverageC+ Formula Quality
Folate · 340 mcg DFEVitamin B12 · 50 mcgVitamin B6 · 25 mgThiamin · 10 mgMagnesium · 50 mg

L-theanine and GABA support calm focus, while B vitamins and magnesium provide neurotransmitter and energy cofactors. The formula is oriented toward stress relief rather than memory or neuroprotection.

Magnesium is only 50 mg and partly comes from poorly absorbed oxide, while B12 uses cyanocobalamin and B6 uses pyridoxine. Numerous vitamins add breadth, but most are unlikely to improve cognition unless intake is inadequate.

Study evidence
Magnesium Supportive 86 studies
Theanine Supportive 17 studies
Vitamin B6 Supportive 29 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 90 mg
Thiamine (Thiamine Hydrochloride, Vitamin B1)
 10 mg
Riboflavin (Vitamin B2)
 10 mg
Niacin (Niacinamide)
 25 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 25 mg
Folate
340 mcg DFE
Vitamin B12 (Cyanocobalamin)
 50 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 10 mg
Magnesium (Magnesium Citrate, Magnesium Oxide)
 50 mg
L-Theanine
100 mg
GABA
200 mg
Gluten Free Adults 18–50 Women
Report overview
Theanine · 100 mg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

The clearly identified L-Theanine dose sits at the start of the optimal range for relaxation and focus support. Its exact amount is easy to verify, although no branded source or purity testing is disclosed. Cost efficiency is competitive for the active amount delivered.

View ingredientView products
Vitamin B6 (Pyridoxine Hydrochloride) · 25 mg OverallScore80
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The formula provides a preferred-range amount of pyridoxine hydrochloride alongside riboflavin, magnesium, L-theanine, and GABA. One capsule delivers the full serving, and the serving cost is favorable for a multi-ingredient blend. Active P-5-P is absent and excipient purity cannot be confirmed from the supplied label data.

View ingredientView products
GABA · 200 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyB- Value

The clearly disclosed GABA amount suits a broad calming blend, although the source is not branded or otherwise characterized. Capsule delivery is practical, and the supporting theanine, magnesium, and B vitamins broaden the formula beyond GABA alone. Value is reasonable, while the incomplete excipient information leaves some uncertainty about label purity.

View ingredientView products
Loading alternative details
76 Performance

Stress-Defy

Irwin Naturals
<p>A wider stress-support blend adds holy basil, skullcap, rhodiola, and ginkgo to L-theanine and GABA. High vitamin B6 and possible ginkgo-related bleeding risk require more caution than the original.</p>
78 Performance

Vitamins Only

Solgar
<p>A broader vitamin profile improves general nutrient coverage beyond the original’s B-vitamin and calming focus. It loses GABA and L-theanine, and its vitamin B6 amount is still high for long-term daily use.</p>
77 Performance

Vitamin B Complex

California Gold Nutrition
<p>Active riboflavin and vitamin B6 forms plus methylated folate improve form quality for the B-vitamin portion of the formula. Label duplication makes total exposure uncertain, and direct calming ingredients are absent.</p>
78 Budget

B-50 Complex

21st Century
<p>A broad B-complex covers the same main vitamin families at substantially better serving value. Conventional forms and high vitamin B6 remain concerns, and the switch removes GABA and L-theanine.</p>
80 Budget

B-Complex plus Vitamin C

21st Century
<p>Core B vitamins and vitamin C offer a much lower-cost option with a more moderate vitamin B6 amount. Missing folate, vitamin B12, biotin, GABA, and L-theanine make it less complete than the original.</p>
80 Budget

Super Vitamin B-Complex

Spring Valley
<p>Broad B-vitamin coverage and a long supply improve value while reducing vitamin B6 exposure compared with the original. Unspecified forms and the absence of calming amino acids are the main trade-offs.</p>
74 Value

Totally Zen

Carlson
<p>The longer-size version supplies essentially the same GABA, L-theanine, magnesium, and B-vitamin formula at slightly better serving value. Mixed magnesium forms and relatively high vitamin B6 remain unchanged drawbacks.</p>
81 Value

Super B-Complex

Nature Made
<p>Broad B-vitamin coverage with vitamin C and a modest vitamin B6 amount makes this a gentler, lower-cost daily nutrient option. It does not replace the original’s GABA or L-theanine for calming support.</p>
77 Value

B-50 Complex

Nature's Way
<p>Active riboflavin and wide B-vitamin coverage offer favorable value compared with the original. High pyridoxine limits long-term appeal, and the formula lacks the original’s calming amino acids.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  5. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  6. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  7. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  8. Current Evidence on Common Dietary Supplements for Sleep Quality.
    Esquivel MK; Ghosn B · American journal of lifestyle medicine · 2025
    Narrative reviewSleep Support forTheanine
  9. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  10. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsStress Relief Sleep Support forGABA
  11. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  12. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA Mood Support Stress Relief forTheanine
  13. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsStress Relief Mood Support forTheanine
  14. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsStress Relief Sleep Support forTheanine
  15. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  16. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  17. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  18. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  19. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  20. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  21. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  22. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  23. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  24. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  25. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  26. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  27. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  28. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  29. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledBrain Health forVitamin B6
  30. Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
    Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
    Cross-sectional study266 participantsBrain Health forVitamin B6
  31. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
    Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Randomized trial180 participantsBrain Health forVitamin B6
  32. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsBrain Health Cognitive Support forVitamin B6
  33. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
    Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
    Scoping review12 studies pooledBrain Health forVitamin B6
  34. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
    Doyle LW; Crowther CA; Middleton P; Marret S; Rouse D · The Cochrane database of systematic reviews · 2009
    Meta-analysis6,145 participants5 studies pooledCognitive Support forMagnesium
  35. Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis.
    Zhang C; Sun L; Sun H · Medicine · 2022
    Meta-analysis1,899 participants22 studies pooledCognitive Support forMagnesium
  36. Effects of magnesium supplementation on serum brain-derived neurotrophic factor levels and cognitive function in patients undergoing fluoxetine therapy for depression.
    Noor NJ; Syamsuddin S; Liaury K; Tawali S; Idris I; Azis I; Lisal ST · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsCognitive Support forMagnesium
  37. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsCognitive Support Energy forMagnesium
  38. Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?
    Hassan WF; Tawfik MH; Nabil TM; Abd Elkareem RM · Minerva anestesiologica · 2021
    Randomized trial80 participantsCognitive Support forMagnesium
  39. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  40. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  41. Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.
    Zhuo C; Xu Y; Wang H; Fang T; Chen J; Zhou C; Li Q; Liu J; Xu S; Yao C; Yang W; Yang A; Li B; Chen Y; Tian H; Lin C · Frontiers in psychiatry · 2021
    Randomized trial200 participantsCognitive Support forVitamin B6
  42. Associations between dietary B vitamin intakes and cognitive function among elderly individuals: An observational study.
    Chen Q; Huang J; Shi X; Peng Y; Chen A; Huang L; Zhang Y; Chen X · Nutrition (Burbank, Los Angeles County, Calif.) · 2025
    Cross-sectional study2,716 participantsCognitive Support forVitamin B6
  43. Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases.
    Zhang C; Hu Y; Cao X; Deng Y; Wang Y; Guan M; Wu X; Jiang H · Scientific reports · 2025
    Cohort study926 participantsCognitive Support forVitamin B6
  44. Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
    Gordon S; Hoey L; McNulty H; Keenan J; Pangilinan F; Brody LC; Ward M; Strain JJ; McAnena L; McCann A; Molloy AM; Cunningham C; McCarroll K; Hughes CF · BMC medicine · 2025
    Observational study4,553 participantsCognitive Support forVitamin B6
  45. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  46. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  47. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  48. Relationship between Whole-Blood Magnesium and Cognitive Performance among Chinese Adults.
    Lu Z; He R; Zhang Y; Li B; Li F; Fu Y; Rong S · Nutrients · 2023
    Cross-sectional study1,006 participantsMental Focus forMagnesium
  49. Serum Magnesium and Cognitive Function Among Qatari Adults.
    Al-Ghazali K; Eltayeb S; Musleh A; Al-Abdi T; Ganji V; Shi Z · Frontiers in aging neuroscience · 2020
    Cross-sectional study1,000 participantsMental Focus forMagnesium
  50. Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis.
    Effatpanah M; Rezaei M; Effatpanah H; Effatpanah Z; Varkaneh HK; Mousavi SM; Fatahi S; Rinaldi G; Hashemi R · Psychiatry research · 2019
    Meta-analysisMental Focus forMagnesium
  51. The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial.
    Hemamy M; Pahlavani N; Amanollahi A; Islam SMS; McVicar J; Askari G; Malekahmadi M · BMC pediatrics · 2021
    Randomized trial33 participantsMental Focus forMagnesium
  52. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
    Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
    Randomized trial100 participantsMental Focus Productivity Boost forMagnesium
  53. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  54. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  55. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort.
    Deijen JB; van der Beek EJ; Orlebeke JF; van den Berg H · Psychopharmacology · 1995
    Randomized trial76 participantsMental Focus forVitamin B6
  56. The effect of vitamin B6 on cognition.
    Malouf R; Grimley Evans J · The Cochrane database of systematic reviews · 2004
    Systematic review109 participants2 studies pooledMental Focus forVitamin B6
  57. Antiemetic use during pregnancy and child neurodevelopment: population-based birth cohort study.
    Cho Y; Choi EY; Han JY; Kim H; Choe YJ; Shin JY · BMC medicine · 2025
    Cohort study630,904 participantsMental Focus forVitamin B6
  58. A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
    Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
    Randomized trial44 participantsMental Focus forVitamin B6
  59. B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial
    Tammy M Scott, Graham Rogers, Daniel E Weiner, Kathryn Livingston, Jacob Selhub, Paul F Jacques, Irwin H Rosenberg, Aron M Troen · The Journal of Prevention of Alzheimer's Disease · 2017
    Randomized trial584 participantsMental Focus forVitamin B6
  60. Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis.
    Zhao B; Deng H; Li B; Chen L; Zou F; Hu L; Wei Y; Zhang W · Diabetes/metabolism research and reviews · 2021
    Meta-analysis1,168 participants26 studies pooledMetabolism Boost forMagnesium
  61. Magnesium supplementation for glycemic status in women with gestational diabetes: a systematic review and meta-analysis.
    Tan X; Huang Y · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Meta-analysis4 studies pooledMetabolism Boost forMagnesium
  62. Impact of oral magnesium supplementation on glycemic and cardiometabolic outcomes in prediabetic adults: a systematic review and meta-analysis.
    Basit A; Kumar S; Ahmed H; Babar R; Saeed SS; Siddiqui TA; Khan S; Saeed A; Khan M; Hanif H; Fasih A; Shabbir S; Kumar H; Kumar L; Raja A; Kumar S; Chander S · Journal of diabetes and metabolic disorders · 2026
    Meta-analysis384 participants5 studies pooledMetabolism Boost forMagnesium
  63. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial.
    Rodríguez-Morán M; Guerrero-Romero F · Diabetes care · 2003
    Randomized trial63 participantsMetabolism Boost forMagnesium
  64. Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Razzaghi R; Pidar F; Momen-Heravi M; Bahmani F; Akbari H; Asemi Z · Biological trace element research · 2018
    Randomized trial70 participantsMetabolism Boost forMagnesium
  65. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  66. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  67. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  68. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  69. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  70. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  71. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  72. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  73. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  74. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  75. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  76. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  77. Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.
    Tao MH; Chuang SC; Wu IC; Chan HT; Cheng CW; Chen HL; Lee MM; Chang HY; Hsiung CA; Hsu CC · European journal of nutrition · 2024
    Cohort study5,663 participantsProductivity Boost forMagnesium
  78. Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.
    Tu X; Qiu H; Lin S; He W; Huang G; Zhang X; Wu Y; He J · Neuropsychiatric disease and treatment · 2022
    Cohort study327 participantsProductivity Boost forMagnesium
  79. Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
    Lai XN; Sadhwani V; Ng WM; Gani A · Cureus · 2025
    Cohort study667 participantsProductivity Boost forMagnesium
  80. Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.
    Chen M; Xue R; Zhang M; Zhang J; Zheng J; Ye D; Sun J · Journal of the American Medical Directors Association · 2025
    Cross-sectional study2,768 participantsProductivity Boost forMagnesium
  81. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  82. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  83. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost forTheanine
  84. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  85. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  86. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  87. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  88. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  89. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  90. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  91. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  92. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  93. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  94. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  95. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  96. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  97. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  98. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  99. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  100. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium Stress Relief forVitamin B6
  101. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  102. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  103. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  104. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6