Product Image

B-100

NOW
4.8
★ ★ ★ ★ ★
(10643 ratings)
Thiamin 100 mg
Niacin 100 mg
Riboflavin 100 mg
PABA 10 mg
Vitamin B5 100 mg
Vitamin B6 100 mg
Choline 10 mg
Product Image
Score76
A complete and economical high-potency formula is held back by basic forms and 100 mg of pyridoxine per serving.
How scoring works
Quantity:250 Capsule(s) • (250 servings)
Goals:
Energy
General Health
Heart Health
Metabolism Boost

Score 76

A complete and economical high-potency formula is held back by basic forms and 100 mg of pyridoxine per serving.
How scoring works

Also available as

3 options
50.00mg • 250 Capsule(s) servings 50.00mg • 250 Capsule(s) • 250 servings $18.99 ($0.07 per serving) 50.00mg • 250 Tablet(s) servings 50.00mg • 250 Tablet(s) • 250 servings $25.50 ($0.10 per serving) 100 servings 1 Veg Capsule(s) • 100 Capsule(s) • 100 servings $13.02 ($0.13 per serving)
$30.95($0.12 per serving)
Vitacost
$ 36.83
Daily Vita
$ 34.70
iHerb
$ 36.74
Amazon
$ 30.95
Nutrition Faktory
$ 34.99
Report prices

Analysis

High amounts of all core B vitamins provide broad coverage for normal energy metabolism. The capsule format and large serving count are convenient for buyers who already know they want this potency.

Cyanocobalamin and pyridoxine hydrochloride are basic forms, while the folate form is unspecified. Choline, inositol, and PABA appear at only 10 mg each, so they contribute little practical value.

A 100 mg vitamin B6 dose is the decisive limitation because it is not well suited to unsupervised long-term daily use. The economical serving format does not offset that safety concern for most routine users.

Who is it for
  • Adults seeking a large-count high-potency B-complex
  • People who prefer capsules over tablets
Best for
  • Broad B-vitamin coverage
  • Long bottle supply

Pros

  • Complete core B-vitamin profile
  • Large number of servings
  • Clearly listed doses
  • Capsule format

Cons

  • Mostly conventional forms
  • Folate form is unspecified
  • Very small choline and inositol amounts
  • Excessive potency for routine use

Warnings

  • Vitamin B6 is supplied as 100 mg of pyridoxine hydrochloride; prolonged daily use may cause tingling, numbness, or other nerve symptoms.

Nutrient quality

62 Moderate impact

Broad coverage and substantial core amounts support the intended use. Standard forms, very high pyridoxine, and token secondary additions weaken the balance.

Ingredient transparency

81 Highest impact

Active amounts are stated and no proprietary blend is shown. The supplied data does not include excipients or full daily-use directions.

Customer satisfaction

73 High impact

The average rating is strong and the large evidence base makes it more dependable. No specific feedback is supplied to judge repeated complaints or alignment with the intended use.

Value for money

89 Highest impact

The large supply provides excellent cost efficiency for a broad B-complex. Standard forms and minor low-dose additions prevent the formula from feeling premium.

Report analysis

Goals

Energy
Energy
Impact
High effect
B+ Goal FitB- Strength of SupportC CoverageA Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

A high-potency B-complex supplies the cofactors needed for carbohydrate, fat, and protein metabolism. Substantial thiamin, riboflavin, niacin, and pantothenic acid create focused support for cellular energy production.

Cyanocobalamin remains below the targeted B12 range for energy, and the formula does not address alertness or stress adaptation. The very high pyridoxine amount raises concern for prolonged daily use because excess vitamin B6 can affect nerves.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
General Health
Daily Energy Vitality
General Health
Impact
High effect
A- Goal FitC- Strength of SupportB- CoverageB Formula Quality
Folate · 680 mcg DFEVitamin B12 · 100 mcg

The broad B-vitamin formula supports energy metabolism and helps cover several common nutritional gaps. Amounts are clearly stated, but cyanocobalamin and pyridoxine are basic forms rather than active alternatives.

Small choline, inositol, and PABA amounts add little to the otherwise high-potency nutrient base. The 100 mg vitamin B6 amount is a meaningful long-term concern because sustained high intake can harm peripheral nerves.

Study evidence
Vitamin B12 Adverse 66 studies
Heart Health
Heart Health
Impact
High effect
C+ Goal FitB- Strength of SupportC CoverageB+ Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 680 mcg DFE

Vitamin B6, folate, and vitamin B12 form a relevant combination for homocysteine metabolism. The formula uses ordinary pyridoxine and cyanocobalamin rather than preferred active forms.

Niacinamide supports basic nutrition but is not the form used for targeted lipid management. The high vitamin B6 amount reaches a chronic-use safety boundary and may raise neuropathy risk with prolonged daily use.

Study evidence
Folate Supportive 116 studies
Niacin Supportive 105 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C Goal FitB- Strength of SupportC CoverageA- Formula Quality
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

The concentrated B-vitamin blend supplies broad cofactor support for cellular energy production. It may help when intake is inadequate, but it is not a direct thermogenic or fat-oxidation formula.

Most amounts are fully disclosed and substantial, while the vitamin forms are generally conventional. The pyridoxine amount is high for routine long-term use, which weakens the practical dose profile despite the formula's focus.

Study evidence
Vitamin B6 Supportive 16 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
C- Goal FitC- Strength of SupportD CoverageC+ Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 680 mcg DFENiacin · 100 mg

Folate, B6, and B12 support homocysteine metabolism, which has a clear cardiovascular connection. The formula does not provide lipid, endothelial, cardiac-energy, or meaningful mineral support.

Cyanocobalamin, pyridoxine, and unspecified folate are less favorable than active forms. Long-term daily use of the very high vitamin B6 amount may cause peripheral neuropathy.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride, Vitamin B1)
 100 mg
Riboflavin (Vitamin B2)
 100 mg
Niacin (Niacinamide, Vitamin B3)
 100 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Folate
680 mcg DFE
Vitamin B12 (Cyanocobalamin)
 100 mcg
Biotin
100 mcg
Pantothenic Acid (Calcium Pantothenate)
 100 mg
Choline (Choline Bitartrate)
 10 mg
Inositol
10 mg
PABA
10 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
Thiamin (Thiamine Hydrochloride, Vitamin B1) · 100 mg OverallScore88
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

A high-potency thiamin dose uses a standard water-soluble form and is fully disclosed. The conventional capsule provides ordinary delivery quality without a premium absorption system. Value is excellent for a broad formula priced below the collection norm.

View ingredientView products
Niacin (Niacinamide, Vitamin B3) · 100 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value

The B-complex provides a substantial niacinamide amount for general nutritional use. A standard capsule offers no special release control, while the clearly disclosed form keeps classic flushing unlikely. Its serving cost is favorable for the amount and the wider B-vitamin profile.

View ingredientView products
Riboflavin (Vitamin B2) · 100 mg OverallScore77
D- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Standard riboflavin requires enzymatic conversion before it becomes metabolically active, while the capsule should dissolve readily. The amount reaches the high-potency range for metabolic support. The low serving cost makes the clearly stated dose highly efficient.

View ingredientView products
Loading alternative details
81 Performance

CellularActive Coenzyme B-Complex

Bluebonnet
<p>Cocarboxylase, riboflavin 5-phosphate, pyridoxal 5-phosphate, methylfolate, and methylcobalamin create a more balanced active-form profile than the original’s conventional 100 mg pattern. Vitamin B6 is held to 25 mg, though mixed methylfolate and folic acid plus only 10 mg choline remain trade-offs.</p>
81 Performance

Activated B-Complex High Bioavailability

Swanson
<p>Benfotiamine, riboflavin 5-phosphate, pyridoxal 5-phosphate, methylfolate, methylcobalamin, and pantethine improve form quality over the original’s conventional 100 mg pattern. The 25 mg B6 amount is more restrained than many high-potency complexes but still deserves care with long-term daily use.</p>
79 Performance

CoEnzyme B-Complex

KAL
<p>Active riboflavin, B6, methylfolate, and methylcobalamin provide broad coenzyme support with a more moderate 20 mg B6 amount than the original’s conventional 100 mg pattern. The chewable adds carbohydrate and also includes cyanocobalamin, while choline remains modest.</p>
77 Budget

B-50

NOW
<p>A much lower recurring cost still provides a complete B-complex with substantial core amounts. Compared with the original’s conventional 100 mg pattern, most forms remain basic and 50 mg of pyridoxine is still high for prolonged daily use.</p>
77 Budget

B-50 Complex 50 mg

Source Naturals
<p>A lower recurring cost preserves broad thiamine, riboflavin, niacin, B6, B12, pantothenic acid, choline, and inositol coverage. Compared with the original’s conventional 100 mg pattern, the formula uses basic forms, while high folate and 50 mg of pyridoxine reduce routine-use balance.</p>
80 Budget

B-Complex '100'

Solgar
<p>A slightly lower recurring cost preserves familiar B-100 potency and broad metabolic coverage. Compared with the original’s conventional 100 mg pattern, it offers little form improvement, and 100 mg of pyridoxine remains poorly suited to prolonged unsupervised use.</p>
76 Value

Hi Potency B Complex

Natural Factors
<p>A low recurring cost and complete 50 mg B-vitamin pattern provide strong supply value. Compared with the original’s conventional 100 mg pattern, conventional forms and very high folate limit quality, while 50 mg pyridoxine remains high for routine long-term use.</p>
75 Value

B-Complex 50

Bluebonnet
<p>A lower-cost 50 mg pattern retains the full set of B vitamins, choline, inositol, and PABA without moving into a 100 or 150 mg formula. Compared with the original’s conventional 100 mg pattern, form quality is basic and 50 mg pyridoxine remains high, so the value is mainly in broad coverage and supply.</p>
76 Value

Mega Vitamin B-Stress

Solaray
<p>A broad B-complex plus vitamin C provides substantial ingredient coverage and a larger supply for the cost. Compared with the original’s conventional 100 mg pattern, the formula adds antioxidant breadth but relies on basic forms, and 100 mg pyridoxine makes indefinite daily use difficult to justify.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  2. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  3. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  4. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  5. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  6. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  7. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  8. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  9. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  10. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  11. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  12. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  13. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  14. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  15. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  16. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  17. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  18. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  19. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  20. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  21. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  22. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  23. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  24. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  25. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  26. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  27. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  28. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  29. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  30. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  31. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  32. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  33. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  34. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  35. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  36. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  37. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  38. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  39. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  40. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  41. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  42. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  43. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  44. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  45. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin
  46. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  47. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  48. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  49. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  50. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  51. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  52. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  53. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  54. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  55. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  56. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  57. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6