BioCoenzymated Active B Complex
Natural Factors
BioCoenzymated Active B Complex
4.8
★ ★ ★ ★ ★
(4218 ratings)
Vitamin B6 25 mg
Thiamin 30 mg
Vitamin B5 100 mg
Niacin 100 mg
Choline 50 mg
Vitamin B12 500 mcg
Riboflavin 10 mg
Score 92.0
A premium B-complex that excels in bioavailability, using active forms of most B vitamins for superior absorption and utilization. It's ideal for those seeking maximum efficacy, despite its higher price.
Quantity: 60 Capsule(s)Servings size: 1 Vegetarian Capsule(s) (60 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
Cognitive Support
leaderboard Score 92.0
A premium B-complex that excels in bioavailability, using active forms of most B vitamins for superior absorption and utilization. It's ideal for those seeking maximum efficacy, despite its higher price.
insights Analysis
This B-complex shines due to its commitment to using bioavailable, coenzymated forms of B vitamins, including Benfotiamine (B1), Riboflavin 5-Phosphate (B2), Inositol Hexanicotinate (non-flushing B3), Pyridoxal 5-Phosphate (P5P for B6), (6S)-5-Methyltetrahydrofolic Acid (L-Methylfolate for B9), and Methylcobalamin (B12). This makes it particularly beneficial for individuals with genetic predispositions (e.g., MTHFR mutations) or absorption issues. The dosages are well-balanced, providing effective amounts without being excessively high, reducing the risk of side effects sometimes associated with standard B-100 complexes. Natural Factors is a respected brand, and the product's high review count reflects consumer appreciation for its quality and effectiveness, especially for energy and cognitive support.
- Contains active/coenzymated forms of most B vitamins (B1, B2, B3 as non-flush, B6, B9, B12), ensuring superior absorption and bioavailability.
- Utilizes L-Methylfolate for Folate, which is crucial for individuals with MTHFR gene variations and generally better absorbed than folic acid.
- Includes Benfotiamine, a fat-soluble form of Thiamine (B1) known for enhanced absorption and tissue penetration.
- Doses are effective yet balanced, minimizing the risk of side effects associated with excessively high levels.
- From Natural Factors, a well-regarded brand known for quality and research-backed formulations.
- Higher price per serving compared to many standard B-complex supplements, which might be a barrier for some budgets.
- Lower dosages of some B vitamins compared to 'B-100' complexes, which may be less impactful for individuals with severe deficiencies seeking very high therapeutic doses.
- Some individuals may experience a yellow discoloration of urine, which is a harmless and common side effect due to the riboflavin content.
$20.97($0.34 per serving)
 iHerb | $ 20.97 | |
 Amazon | $ 20.97 |
bolt Effectiveness for goals
B vitamin complexes support various bodily functions, including energy metabolism, nervous system health, and red blood cell formation. They play crucial roles in converting food into energy and maintaining cellular health. Different B vitamins often work synergistically to achieve these effects.
Coenzymated, or active, forms of B vitamins are already in the metabolic form the body uses, bypassing conversion steps. This can potentially lead to more efficient utilization and bioavailability compared to their inactive precursors. Examples include methylcobalamin for B12 and pyridoxal 5-phosphate for B6.
Thiamine hydrochloride is a water-soluble form of Vitamin B1, while benfotiamine is a lipid-soluble derivative. Benfotiamine may offer enhanced absorption and prolonged presence in the body, particularly beneficial for nerve tissue. This combination aims to provide comprehensive thiamine support.
Folate and vitamin B12 are essential cofactors in the one-carbon metabolism cycle, which is crucial for DNA synthesis, repair, and methylation processes. They are interdependent for the proper formation of red blood cells and the maintenance of nervous system function. Adequate levels of both are necessary for the metabolism of homocysteine.
Vitamins B6, B12, and folate are key players in the metabolic pathways that convert homocysteine into other beneficial molecules. They help break down homocysteine, preventing its accumulation in the blood. Maintaining healthy homocysteine levels is important for overall cardiovascular health.
schedule Dosage, timing & forms
Many people prefer taking B complex supplements in the morning with food to support energy metabolism throughout the day. Taking them with a meal can also help minimize stomach upset and enhance absorption. While there's no strict rule, consistency is often considered more important than specific timing.
Active or coenzymated forms, such as methylcobalamin for B12 or pyridoxal 5-phosphate for B6, are already in the forms the body can readily use. This may improve bioavailability and absorption, especially for individuals with genetic variations affecting vitamin conversion. It reduces the need for the body to convert them before utilization.
Thiamine hydrochloride is a water-soluble form, while benfotiamine is a fat-soluble derivative. Benfotiamine is often included for its enhanced absorption and ability to remain in the body longer, potentially offering different physiological benefits. This combination aims to provide comprehensive thiamine support.
Inositol and choline are often grouped with B vitamins due to their similar functions, particularly in cell membrane health and nerve signaling. They work synergistically to support cognitive function, fat metabolism, and liver health. Their combined presence complements the actions of other B vitamins.
Inositol Hexanicotinate is often referred to as a "no-flush" form of niacin, meaning it's less likely to cause the common niacin flush (redness, itching). It releases niacin slowly in the body, providing its benefits without the uncomfortable side effect often associated with nicotinic acid. This makes it a preferred choice for sustained niacin support.
health_and_safety Safety & interactions
Certain B vitamins may interact with some medications. For instance, vitamin B6 can affect some Parkinson's disease medications, and folate may interact with certain anticonvulsants or methotrexate. It is advisable to consult a healthcare professional regarding potential interactions.
High doses of biotin can interfere with certain laboratory tests, particularly those that use biotin technology, such as tests for thyroid hormones and cardiac troponin. This can lead to falsely high or low results, which may affect diagnosis and treatment. It is recommended to inform your doctor and stop biotin supplementation a few days before having blood tests.
This complex uses inositol hexanicotinate, which is often referred to as a 'no-flush' form of niacin. This form is generally less likely to cause the common skin flushing sensation associated with nicotinic acid. However, individual sensitivities can vary.
Individuals with certain genetic variations, like MTHFR, may benefit from the methylfolate form provided, as it is readily utilized by the body. However, high doses of folate can potentially mask a vitamin B12 deficiency or interact with anticonvulsant medications. Always discuss supplement use with a healthcare provider if you have specific health conditions or take prescription drugs.
Metformin, a medication commonly used for type 2 diabetes, can sometimes lead to reduced absorption of vitamin B12 over time. Supplementing with vitamin B12 may help address this potential deficiency. However, it's important to monitor B12 levels and discuss supplementation with a healthcare professional.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Thiamine | 30 mg |
Riboflavin | 10 mg |
Niacin | 100 mg |
Vitamin B6 | 25 mg |
Folate | 680 mcg DFE |
Vitamin B12 | 500 mcg |
Biotin | 250 mcg |
Pantothenic Acid | 100 mg |
Choline | 50 mg |
Inositol | 25 mg |
Categories
Vitamin B12 100.0
Contains 500mcg of Methylcobalamin, the active and most bioavailable form of B12, ensuring optimal absorption and utilization for neurological and energy functions.
Vitamin B6 100.0
Features 25mg of Pyridoxal 5-Phosphate (P5P), the active and most readily usable form of B6, which is crucial for over 100 enzymatic reactions in the body and bypasses the need for liver conversion.
Riboflavin 100.0
Provides 10mg of Riboflavin 5-Phosphate, the active coenzyme form of Vitamin B2, ensuring immediate bioavailability and efficient utilization in cellular energy production.
Goals
Energy 95.0
By providing B vitamins in their active, readily usable forms, this product ensures efficient conversion of food into energy, offering robust and sustained energy support for the body.
Brain Health 95.0
The coenzymated forms of B6, B9 (L-Methylfolate), and B12 (Methylcobalamin) are critical for neurotransmitter synthesis and nerve health, making this highly effective for optimal brain function and support.
Mood Support 95.0
Active B vitamins directly support the production of mood-regulating neurotransmitters, making this complex highly effective for promoting a balanced mood and emotional well-being.
Recommended Alternatives
87 Value 
High Potency Vitamin B Complex
Lake Avenue Nutrition
4.5
★★★★★
(5973 ratings)
Offers an excellent balance of active B vitamin forms (B2, B6, B9, B12) at competitive price points, providing great bioavailability and strong potency without the highest premium cost.
88 Value 
B-Complex
Paradise Earth's Blend
4.7
★★★★★
(4459 ratings)
Combines active B vitamin forms (Methylcobalamin, L-Methylfolate, P5P, Benfotiamine) with a blend of superfoods and adaptogens, offering comprehensive active B vitamin support at a reasonable price for its quality.
85 Value 
Activated B-Complex High Bioavailability
Swanson
4.9
★★★★★
(1190 ratings)
Provides a B-complex with several active forms (Methylcobalamin, L-5-Methyltetrahydrofolate, P5P) at a mid-range price, making it a solid choice for those seeking better absorption than standard B-complexes without the highest cost.
95 Performance 
Advanced Nutrients
Thorne
4.6
★★★★★
(851 ratings)
A very high-quality comprehensive multivitamin with excellent active forms of B vitamins, plus many other beneficial nutrients, offering superior overall nutritional support for optimal health.
93 Performance 
Two-Per-Day Capsules
Life Extension
4.7
★★★★★
(85932 ratings)
A highly comprehensive multivitamin that includes excellent active forms of B vitamins (Methylcobalamin, L-5-Methyltetrahydrofolate, P5P, Riboflavin 5-Phosphate) in effective doses, along with a wide array of other crucial nutrients.
96 Performance 
Life Extension Mix Capsules
Life Extension
4.7
★★★★★
(492 ratings)
An ultra-comprehensive multi-nutrient formula that includes very high doses of active B vitamins (Methylcobalamin, L-5-Methyltetrahydrofolate, P5P, Riboflavin 5-Phosphate), along with an extensive range of vitamins, minerals, and phytonutrients for maximum health optimization.
78 Budget 
Hi Potency B Complex
Natural Factors
4.7
★★★★★
(13054 ratings)
Offers a general high-potency B-complex from the same reputable brand at a lower price, though it mostly uses standard B vitamin forms, sacrificing some of the 'active' benefits.
80 Budget 
B-50
NOW
4.7
★★★★★
(33178 ratings)
A well-balanced B-50 complex with standard, well-tolerated forms of B vitamins at a much more affordable price per serving, providing good general support.
60 Budget 
B 50 Complex
Thompson
4.7
★★★★★
(2864 ratings)
A very cost-effective basic B-50 complex, suitable for general supplementation needs without the premium price of active forms.
87 Value
High Potency Vitamin B Complex
Lake Avenue Nutrition
4.5
★★★★★
(5973 ratings)
Offers an excellent balance of active B vitamin forms (B2, B6, B9, B12) at competitive price points, providing great bioavailability and strong potency without the highest premium cost.
88 Value
B-Complex
Paradise Earth's Blend
4.7
★★★★★
(4459 ratings)
Combines active B vitamin forms (Methylcobalamin, L-Methylfolate, P5P, Benfotiamine) with a blend of superfoods and adaptogens, offering comprehensive active B vitamin support at a reasonable price for its quality.
85 Value
Activated B-Complex High Bioavailability
Swanson
4.9
★★★★★
(1190 ratings)
Provides a B-complex with several active forms (Methylcobalamin, L-5-Methyltetrahydrofolate, P5P) at a mid-range price, making it a solid choice for those seeking better absorption than standard B-complexes without the highest cost.
95 Performance
Advanced Nutrients
Thorne
4.6
★★★★★
(851 ratings)
A very high-quality comprehensive multivitamin with excellent active forms of B vitamins, plus many other beneficial nutrients, offering superior overall nutritional support for optimal health.
93 Performance
Two-Per-Day Capsules
Life Extension
4.7
★★★★★
(85932 ratings)
A highly comprehensive multivitamin that includes excellent active forms of B vitamins (Methylcobalamin, L-5-Methyltetrahydrofolate, P5P, Riboflavin 5-Phosphate) in effective doses, along with a wide array of other crucial nutrients.
96 Performance
Life Extension Mix Capsules
Life Extension
4.7
★★★★★
(492 ratings)
An ultra-comprehensive multi-nutrient formula that includes very high doses of active B vitamins (Methylcobalamin, L-5-Methyltetrahydrofolate, P5P, Riboflavin 5-Phosphate), along with an extensive range of vitamins, minerals, and phytonutrients for maximum health optimization.