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Calcium Plus Mixed Berry Flavor

Pure Essence Ionic-Fizz
4.7
ā˜… ā˜… ā˜… ā˜… ā˜…
(61 ratings)
Folate 50 mcg
Potassium 100 mg
Calcium 250 mg
Vitamin A 250 IU
Vitamin D 100 IU
Magnesium 300 mg
Product Image
Score68
A convenient mineral drink with balanced calcium and magnesium plus active B vitamins. Low vitamin D and several lightly dosed extras limit its completeness.
How scoring works
Quantity:14 Liquid(s) ā€¢ (60 servings)
Goals:
General Health
Bone Health
Energy
Stress Relief

Score 68

A convenient mineral drink with balanced calcium and magnesium plus active B vitamins. Low vitamin D and several lightly dosed extras limit its completeness.
How scoring works
$44.80($0.74 per serving)
Pure Formulas
$ 44.80
iHerb
$ 44.80
iHerb
$ 44.80
Report prices

Analysis

Calcium lactate and magnesium carbonate provide a balanced mineral base in a flavored liquid. Potassium, zinc, boron, and a small vitamin D3 amount broaden bone and muscle nutrient coverage.

Quatrefolic and methylcobalamin are good B-vitamin forms, though their amounts are secondary to the mineral focus. Bamboo, beet, grape skin, and sea-mineral additions are small and do not clearly drive the product's value.

The drink format may help users who dislike pills and offers sixty servings. It works best as a moderate calcium-magnesium supplement, not a complete bone formula.

Who is it for
  • Adults who prefer drink-mix minerals
  • People seeking moderate calcium and magnesium
  • Users avoiding large tablets
Best for
  • Pill-free mineral support
  • Daily calcium and magnesium intake
  • Flavored hydration routines

Pros

  • Balanced calcium and magnesium
  • Uses active folate and B12
  • Includes potassium and boron
  • Sixty servings

Cons

  • Vitamin D amount is very low
  • Magnesium carbonate is a basic form
  • Several botanical extras are lightly dosed
  • Premium daily cost

Warnings

  • The 300 mg supplemental magnesium amount may loosen stools
  • Calcium should be spaced from levothyroxine and tetracycline or quinolone antibiotics
  • People with kidney disease need guidance before concentrated mineral use

Nutrient quality

70 High impact

Magnesium is meaningful, but calcium is modest and vitamin D and zinc are lightly dosed for bone support. No listed amount appears excessive for general use.

Ingredient transparency

78 High impact

Each listed active ingredient has a specific amount. No proprietary blend hides a listed active dose.

Customer satisfaction

64 Moderate impact

The strong rating is encouraging, but the review base is small. No review text is available to assess recurring complaints or firsthand results.

Value for money

57 Moderate impact

Useful magnesium and good B-vitamin forms partly justify the cost. The long bottle life supports fair serving value despite modest calcium and vitamin D.

Report analysis

Goals

General Health
Stress Resilience
General Health
Impact
High effect
B+ Goal FitC+ Strength of SupportB CoverageB Formula Quality
Folate Ā· 50 mcgVitamin B12 Ā· 30 mcgVitamin D Ā· 100 IUMagnesium Ā· 300 mgBoron Ā· 500 mcgZinc Ā· 2 mgVitamin C Ā· 250 mg

The mineral drink combines calcium and magnesium with vitamin D, boron, and several supporting nutrients. Its strongest contribution is broad skeletal and mineral support.

Calcium and magnesium are substantial, but magnesium carbonate has poor absorption potential. Active folate and B12 forms are welcome, though their amounts and the vitamin D amount are modest.

Study evidence
Boron Supportive 6 studies
Folate Supportive 80 studies
Magnesium Supportive 114 studies
Vitamin D Supportive 115 studies
Zinc Supportive 60 studies
Bone Health
Bone Mineral Preservation
Bone Health
Impact
High effect
A- Goal FitD+ Strength of SupportB- CoverageB Formula Quality
Magnesium Ā· 300 mgCalcium Ā· 250 mgVitamin D Ā· 100 IUCopper Ā· 0.25 mgManganese Ā· 1 mgBoron Ā· 500 mcgZinc Ā· 2 mgVitamin C Ā· 250 mg

The drink mix is broadly designed around structural minerals and their cofactors. Calcium, magnesium, vitamin D3, potassium, boron, and trace minerals address several bone pathways.

Vitamin D, folate, potassium, zinc, and boron are lightly dosed, while calcium lactate and magnesium carbonate are not ideal forms. The formula is comprehensive on paper but uneven in delivered depth.

Study evidence
Boron Supportive 5 studies
Calcium Supportive 144 studies
Folate Supportive 50 studies
Magnesium Supportive 48 studies
Potassium Supportive 39 studies
Vitamin D Supportive 202 studies
Zinc Supportive 33 studies
Energy
Physical Stamina
Energy
Impact
High effect
B+ Goal FitB- Strength of SupportC CoverageC Formula Quality
Vitamin D Ā· 100 IUMagnesium Ā· 300 mgVitamin B12 Ā· 30 mcgPotassium Ā· 100 mg

Magnesium reaches a meaningful amount for ATP-related enzyme activity and muscle function. Potassium and methylcobalamin add electrolyte and metabolic support, though both are modest.

Magnesium carbonate has limited absorption potential and vitamin D is far below a useful daily amount. The bone-focused formula contains several tiny plant additions that contribute little to energy.

Study evidence
Magnesium Supportive 4 studies
Potassium Supportive 2 studies
Vitamin D Supportive 32 studies
Stress Relief
Stress Relief
Impact
High effect
B- Goal FitB- Strength of SupportD+ CoverageC- Formula Quality
Vitamin D Ā· 100 IUMagnesium Ā· 300 mgFolate Ā· 50 mcgVitamin B12 Ā· 30 mcgVitamin B6 Ā· 1 mgVitamin C Ā· 250 mg

Magnesium supports nervous-system regulation and muscle relaxation, with the clearest benefit when intake is inadequate. Its physiological role is established, while human evidence for reducing perceived stress in otherwise replete users is less robust than for targeted adaptogens or theanine.

The 300 mg elemental magnesium amount reaches a useful supplemental range. Magnesium carbonate is poorly absorbed, although the label clearly states the amount and uses active folate and methylcobalamin.

Study evidence
Folate Supportive 19 studies
Magnesium Supportive 13 studies
Vitamin B6 Supportive 10 studies
Heart Health
Healthy Blood Pressure
Heart Health
Impact
Moderate effect
B- Goal FitC Strength of SupportC- CoverageC+ Formula Quality
Magnesium Ā· 300 mgVitamin B12 Ā· 30 mcgVitamin B6 Ā· 1 mgFolate Ā· 50 mcgVitamin D Ā· 100 IU

Magnesium reaches a substantial amount and supports vascular tone and cardiac physiology. Methylfolate, methylcobalamin, potassium, and vitamin D add several related nutrient pathways.

Magnesium carbonate absorbs poorly, while folate, potassium, vitamin D, and zinc are underdosed. Small botanical and sea-mineral additions add label breadth without meaningful heart potency.

Study evidence
Folate Supportive 116 studies
Magnesium Supportive 158 studies
Potassium Supportive 182 studies
Vitamin D Mixed 164 studies
Cardiovascular Support
Arterial Integrity and Protection
Cardiovascular Support
Impact
Moderate effect
C Goal FitC- Strength of SupportC CoverageB- Formula Quality
Potassium Ā· 100 mgMagnesium Ā· 300 mgVitamin D Ā· 100 IUVitamin B12 Ā· 30 mcgVitamin B6 Ā· 1 mgFolate Ā· 50 mcgVitamin C Ā· 250 mg

Magnesium, potassium, active folate, methylcobalamin, and a small beet component provide several cardiovascular links. The product is primarily a calcium-mineral drink, so heart support is secondary.

The magnesium amount is substantial, but carbonate has weaker absorption potential and potassium is modest. Very small botanical additions create breadth on paper without adding much functional depth.

Study evidence
Folate Supportive 93 studies
Magnesium Supportive 123 studies
Potassium Supportive 117 studies
Vitamin D Mixed 170 studies
Digestive Health
Digestive Health
Impact
Moderate effect
C Goal FitC+ Strength of SupportD CoverageD+ Formula Quality
Zinc Ā· 2 mgVitamin A Ā· 250 IUVitamin D Ā· 100 IUMagnesium Ā· 300 mg

Magnesium carbonate may support bowel motility at a substantial amount, but it is primarily included in a bone-mineral drink. The formula lacks fiber, enzymes, probiotics, or targeted mucosal actives.

The elemental amount is clear, while carbonate offers less predictable absorption and motility than citrate. Magnesium can cause diarrhea or cramping, especially when combined with other magnesium products.

Study evidence
Magnesium Supportive 50 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene)
 250 IU
Vitamin C (Ascorbic Acid)
 250 mg
Vitamin D3
100 IU
Vitamin B6 (Pyridoxine Hydrochloride)
 1 mg
Folate (Quatrefolic)
 50 mcg
Vitamin B12 (Methylcobalamin)
 30 mcg
Calcium (Calcium Lactate)
 250 mg
Magnesium (Magnesium Carbonate)
 300 mg
Zinc (Zinc Lactate)
 2 mg
Copper (Copper Gluconate)
 0.25 mg
Manganese (Manganese Gluconate)
 1 mg
Potassium (Potassium Bicarbonate)
 100 mg
Bamboo extract
60 mg
Beet root powder
10 mg
ionic Sea Minerals
10 mg
Grape skin extract
8 mg
Boron (Boron Citrate)
 500 mcg
Gluten Free Adults 18ā€“50 Vegan Women Vegetarian
Report overview
Folate (Quatrefolic) Ā· 50 mcg OverallScore68
A+ Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyD- Value

Quatrefolic provides a validated body-ready form with strong source clarity. The folate amount is very low even though methylcobalamin is included at a useful level. The larger package improves value, but the serving remains underdosed for folate support.

View ingredientView products
Potassium (Potassium Bicarbonate) Ā· 100 mg OverallScore66
A+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyD- Value

Potassium bicarbonate provides a well-absorbed alkalizing source. The 100 mg amount is low, and the label does not fully separate compound weight from elemental yield. Value is fair but depends more on the broader calcium drink mix than on potassium delivery.

View ingredientView products
Calcium (Calcium Lactate) Ā· 250 mg OverallScore60
D- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD+ Value

Calcium lactate limits the formulation because of its low elemental yield. The serving amount supports general supplementation rather than high calcium needs on its own; no listed purity concern materially weakens the formulation. The moderately elevated serving cost provides fair rather than strong value.

View ingredientView products
Loading alternative details
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LifeTIME
The ingredient profile offers a potentially stronger fit for the overlapping nutrient needs than the original. Calcium citrate, magnesium citrate, and vitamin D3 create a well-focused liquid with useful doses.
79 Performance

Magnesium Plus Mixed Berry Flavor

Pure Essence Ionic-Fizz
The ingredient profile offers a potentially stronger fit for the overlapping nutrient needs than the original. A substantial magnesium amount supports the drink's mineral focus, while methylfolate and methylcobalamin add useful B-vitamin coverage.
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The ingredient profile offers a potentially stronger fit for the overlapping nutrient needs than the original. Calcium citrate and magnesium citrate support absorption, but vitamin D2 and magnesium oxide weaken the form profile.
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The supplied serving-cost data indicates a less expensive option than the original. Calcium citrate provides a useful core dose, but magnesium oxide is a weaker form and vitamin D3 is modest.
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The balance of formulation quality and serving efficiency makes it a practical value candidate compared with the original. A substantial magnesium amount supports the drink's mineral focus, while methylfolate and cyanocobalamin add useful B-vitamin coverage.
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The balance of formulation quality and serving efficiency makes it a practical value candidate compared with the original. The liquid combines vitamin D3 with substantial calcium and magnesium, but the supplied form entries are internally unclear.
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Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y Ā· European journal of clinical nutrition Ā· 2026
    Randomized trial612 participantsBone Health forVitamin D
  2. Effect of monthly high-dose vitamin D on bone density in community-dwelling older adults substudy of a randomized controlled trial.
    Reid IR; Horne AM; Mihov B; Gamble GD; Al-Abuwsi F; Singh M; Taylor L; Fenwick S; Camargo CA; Stewart AW; Scragg R Ā· Journal of internal medicine Ā· 2017
    Randomized trial452 participantsBone Health forVitamin D
  3. Effects of Vitamin D Supplementation on Bone Turnover and Bone Mineral Density in Healthy Men: A Post-Hoc Analysis of a Randomized Controlled Trial.
    Lerchbaum E; Trummer C; Theiler-Schwetz V; Kollmann M; Wƶlfler M; Pilz S; Obermayer-Pietsch B Ā· Nutrients Ā· 2019
    Randomized trial200 participantsBone Health forVitamin D
  4. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y Ā· Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Ā· 2022
    Randomized trial193 participantsBone Health forVitamin D
  5. Vitamin D and HRT: no benefit additional to that of HRT alone in prevention of bone loss in early postmenopausal women. A 2.5-year randomized placebo-controlled study.
    Komulainen M; Tuppurainen MT; Krƶger H; Heikkinen AM; Puntila E; Alhava E; Honkanen R; Saarikoski S Ā· Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Ā· 1997
    Randomized trial464 participantsBone Health forVitamin D
  6. Associations of dietary calcium intake with metabolic syndrome and bone mineral density among the Korean population: KNHANES 2008-2011.
    Kim MK; Chon SJ; Noe EB; Roh YH; Yun BH; Cho S; Choi YS; Lee BS; Seo SK Ā· Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Ā· 2018
    Cross-sectional study14,705 participantsBone Health forCalcium
  7. Treatment with alendronate plus calcium, alendronate alone, or calcium alone for postmenopausal low bone mineral density.
    Bonnick S; Broy S; Kaiser F; Teutsch C; Rosenberg E; DeLucca P; Melton M Ā· Current medical research and opinion Ā· 2007
    Randomized trial701 participantsBone Health forCalcium
  8. Dietary calcium intake protects women consuming oral contraceptives from spine and hip bone loss.
    Teegarden D; Legowski P; Gunther CW; McCabe GP; Peacock M; Lyle RM Ā· The Journal of clinical endocrinology and metabolism Ā· 2005
    Randomized trial154 participantsBone Health forCalcium
  9. Relationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: a meta-regression.
    Rabenda V; BruyĆØre O; Reginster JY Ā· Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Ā· 2011
    Meta-analysis47,365 participants15 studies pooledBone Health forCalcium
  10. Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
    Tihtonen K; Korhonen P; IsojƤrvi J; Ojala R; Ashorn U; Ashorn P; Tammela O Ā· Annals of the New York Academy of Sciences Ā· 2022
    Meta-analysis1,566 participants7 studies pooledBone Health forCalcium
  11. Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial.
    Jehle S; Hulter HN; Krapf R Ā· The Journal of clinical endocrinology and metabolism Ā· 2013
    Randomized trial201 participantsBone Health forPotassium
  12. Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia.
    Jehle S; Zanetti A; Muser J; Hulter HN; Krapf R Ā· Journal of the American Society of Nephrology : JASN Ā· 2007
    Randomized trial161 participantsBone Health forPotassium
  13. Effects of Potassium Citrate Supplementation on Bone Turnover Markers in Postmenopausal Women: A GRADE-Assessed Systematic Review, Meta-analysis and Trial Sequential Analysis.
    AlSejari N; Alkhulaifi NS; Alenezi RS; Alharran AM; Alsubaiei AA Ā· Calcified tissue international Ā· 2026
    Meta-analysis401 participants5 studies pooledBone Health forPotassium
  14. Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial.
    Macdonald HM; Black AJ; Aucott L; Duthie G; Duthie S; Sandison R; Hardcastle AC; Lanham New SA; Fraser WD; Reid DM Ā· The American journal of clinical nutrition Ā· 2008
    Randomized trial276 participantsBone Health forPotassium
  15. Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women.
    Dawson-Hughes B; Harris SS; Palermo NJ; Castaneda-Sceppa C; Rasmussen HM; Dallal GE Ā· The Journal of clinical endocrinology and metabolism Ā· 2009
    Randomized trial171 participantsBone Health forPotassium
  16. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G Ā· Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine Ā· 2022
    Narrative reviewBone Health forMagnesium
  17. Association between magnesium deficiency scores and hip bone health in adults: a population-based study.
    Li S; Chang W; Wu G; Wang K; Sun X; Sun H; Zhou J Ā· Magnesium research Ā· 2025
    Cross-sectional study13,259 participantsBone Health forMagnesium
  18. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD Ā· The American journal of clinical nutrition Ā· 2014
    Cohort study73,684 participantsBone Health forMagnesium
  19. Dialysate Magnesium and Coronary Artery Calcification, Bone Mineral Density, and Cramping in Maintenance Hemodialysis: A Quasi-experimental Study.
    Srisuwarn P; Sethakarun S; Nongnuch A; Jongjirasiri S; Sritara C; Klyprayong P; Disthabanchong S Ā· Kidney medicine Ā· 2022
    Non-randomized trial40 participantsBone Health forMagnesium
  20. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects.
    Ryder KM; Shorr RI; Bush AJ; Kritchevsky SB; Harris T; Stone K; Cauley J; Tylavsky FA Ā· Journal of the American Geriatrics Society Ā· 2006
    Cross-sectional study2,038 participantsBone Health forMagnesium
  21. Associations of Dietary Intakes of Calcium, Magnesium, and Soy Isoflavones With Bone Fracture Risk in Men: A Prospective Study.
    Cui Y; Cai H; Zheng W; Shu XO Ā· JBMR plus Ā· 2026
    Cohort study61,025 participantsBone Health forMagnesium
  22. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E Ā· Neurogastroenterology and motility Ā· 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  23. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H Ā· Journal of neurogastroenterology and motility Ā· 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  24. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation.
    Bu LN; Chang MH; Ni YH; Chen HL; Cheng CC Ā· Pediatrics international : official journal of the Japan Pediatric Society Ā· 2007
    Randomized trial45 participantsDigestive Health forMagnesium
  25. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS Ā· The New England journal of medicine Ā· 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  26. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H Ā· Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland Ā· 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  27. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    JosĆ© RamĆ³n V; Mora Mora M; Marino AlarcĆ³n O; HernĆ”ndez G; Josefina Linares L; Urdaneta Romero H; ArĆ©valo GonzĆ”lez E Ā· Investigacion clinica Ā· 2013
    Case-control study45 participantsBone Health forBoron
  28. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR Ā· FASEB journal : official publication of the Federation of American Societies for Experimental Biology Ā· 1987
    Single-arm trial12 participantsBone Health forBoron
  29. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S Ā· Magnesium research Ā· 1994
    Narrative reviewBone Health forBoron
  30. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL Ā· Environmental health perspectives Ā· 1995
    Randomized trial28 participantsBone Health forBoron
  31. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen Ā· The American Journal of Clinical Nutrition Ā· 1997
    Non-randomized trial11 participantsBone Health forBoron
  32. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S Ā· International journal of older people nursing Ā· 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  33. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ Ā· The Journal of clinical endocrinology and metabolism Ā· 1998
    Randomized trial60 participantsBone Health forCalcium
  34. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A Ā· Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Ā· 1995
    Randomized trial168 participantsBone Health forCalcium
  35. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H Ā· Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Ā· 2014
    Randomized trial404 participantsBone Health forCalcium
  36. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R Ā· The Journal of clinical investigation Ā· 1997
    Randomized trial149 participantsBone Health forCalcium
  37. Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
    Wei H; Jin Z; Zhou L; Tang G; Chai S; Che X; Tan Y; Zeng W Ā· Frontiers in endocrinology Ā· 2025
    Cross-sectional study1,315 participantsBone Health forFolate
  38. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
    Liu CT; Karasik D; Xu H; Zhou Y; Broe K; Cupples LA; Cpgm de Groot L; Ham A; Hannan MT; Hsu YH; Jacques P; McLean RR; Paul L; Selhub J; Trajanoska K; van der Velde N; van Schoor N; Kiel DP Ā· The American journal of clinical nutrition Ā· 2021
    Cohort study4,310 participantsBone Health forFolate
  39. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G Ā· Current aging science Ā· 2022
    Narrative review35,298 participants29 studies pooledBone Health forFolate
  40. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
    Cagnacci A; Baldassari F; Rivolta G; Arangino S; Volpe A Ā· Bone Ā· 2004
    Cross-sectional study161 participantsBone Health forFolate
  41. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
    Rejnmark L; Vestergaard P; Hermann AP; Brot C; Eiken P; Mosekilde L Ā· Calcified tissue international Ā· 2008
    Cohort study1,869 participantsBone Health forFolate
  42. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; PĆ©rez-Albela JL; VĆ”squez-LĆ³pez VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M Ā· Nutrients Ā· 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  43. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY Ā· Craniomaxillofacial trauma & reconstruction Ā· 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  44. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J Ā· Biomaterials Ā· 2016
    Randomized trial48 participantsBone Health forMagnesium
  45. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z Ā· Endocrine connections Ā· 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  46. Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women.
    Frassetto L; Morris RC; Sebastian A Ā· The Journal of clinical endocrinology and metabolism Ā· 2005
    Randomized trial170 participantsBone Health forPotassium
  47. Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women.
    Moseley KF; Weaver CM; Appel L; Sebastian A; Sellmeyer DE Ā· Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Ā· 2013
    Randomized trial52 participantsBone Health forPotassium
  48. Effects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensives.
    He FJ; Marciniak M; Carney C; Markandu ND; Anand V; Fraser WD; Dalton RN; Kaski JC; MacGregor GA Ā· Hypertension (Dallas, Tex. : 1979) Ā· 2010
    Randomized trial42 participantsBone Health forPotassium
  49. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group Ā· The American journal of clinical nutrition Ā· 2024
    Randomized trial454 participantsBone Health forVitamin D
  50. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F Ā· BoneKEy reports Ā· 2014
    Narrative reviewBone Health forVitamin D
  51. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S Ā· Critical reviews in food science and nutrition Ā· 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  52. Increased incidence of fractures in middle-aged and elderly men with low intakes of phosphorus and zinc.
    ElmstĆ„hl S; Gullberg B; Janzon L; Johnell O; ElmstĆ„hl B Ā· Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Ā· 1999
    Cohort study6,576 participantsBone Health forZinc
  53. Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.
    Berger PK; Pollock NK; Laing EM; Chertin V; Bernard PJ; Grider A; Shapses SA; Ding KH; Isales CM; Lewis RD Ā· The Journal of nutrition Ā· 2016
    Randomized trial147 participantsBone Health forZinc
  54. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth.
    Merialdi M; Caulfield LE; Zavaleta N; Figueroa A; Costigan KA; Dominici F; Dipietro JA Ā· The American journal of clinical nutrition Ā· 2004
    Randomized trial242 participantsBone Health forZinc
  55. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A Ā· Saudi medical journal Ā· 2009
    Randomized trial60 participantsBone Health forZinc
  56. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
    Ceylan MN; Akdas S; Yazihan N Ā· Biological trace element research Ā· 2021
    Meta-analysis40 studies pooledBone Health forZinc
  57. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L Ā· European journal of clinical nutrition Ā· 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  58. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J Ā· Journal of the American Heart Association Ā· 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  59. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ Ā· The American journal of cardiology Ā· 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  60. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH Ā· Journal of internal medicine Ā· 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  61. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ Ā· Circulation Ā· 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  62. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D Ā· The American journal of clinical nutrition Ā· 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  63. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K Ā· PloS one Ā· 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  64. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M Ā· Journal of cardiovascular pharmacology Ā· 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  65. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H Ā· Current atherosclerosis reports Ā· 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium Cardiovascular Support Heart Health forVitamin D
  66. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J Ā· Journal of nephrology Ā· 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  67. Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies.
    Gan L; Zhao B; Inoue-Choi M; Liao LM; Graubard BI; Weinstein SJ; Albanes D; Huang J Ā· BMC medicine Ā· 2024
    Meta-analysis416,104 participantsCardiovascular Support forPotassium
  68. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.
    D'Elia L; Barba G; Cappuccio FP; Strazzullo P Ā· Journal of the American College of Cardiology Ā· 2011
    Meta-analysis247,510 participants11 studies pooledCardiovascular Support Heart Health forPotassium
  69. Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials.
    Geleijnse JM; Kok FJ; Grobbee DE Ā· Journal of human hypertension Ā· 2003
    Meta-analysis27 studies pooledCardiovascular Support forPotassium
  70. Twenty-Four-Hour Urinary Sodium and Potassium Excretion and Their Associations With Blood Pressure Among Adults in China: Baseline Survey of Action on Salt China.
    Li Y; Zhang P; Wu J; Ma J; Xu J; Zhang X; Luo R; Liu M; Sun Y; Li X; Tan M; He FJ; MacGregor GA; Li X Ā· Hypertension (Dallas, Tex. : 1979) Ā· 2021
    Cross-sectional study5,353 participantsCardiovascular Support forPotassium
  71. Dietary Sodium and Potassium Intake and Risk of Non-Fatal Cardiovascular Diseases: The Million Veteran Program.
    Wang DD; Li Y; Nguyen XT; Song RJ; Ho YL; Hu FB; Willett WC; Wilson PWF; Cho K; Gaziano JM; DjoussĆ© L; On Behalf Of The Va Million Veteran Program Ā· Nutrients Ā· 2022
    Cohort study180,156 participantsCardiovascular Support forPotassium
  72. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V Ā· Journal of the American Society of Nephrology : JASN Ā· 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  73. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; MagalhĆ£es R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; MagalhĆ£es J; Sougey E; Silva T; Junio A; Bandeira F; LeĆ£o R Ā· American heart journal plus : cardiology research and practice Ā· 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  74. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y Ā· PloS one Ā· 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  75. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F Ā· Hypertension (Dallas, Tex. : 1979) Ā· 2015
    Randomized trial88 participantsCardiovascular Support Heart Health forVitamin D
  76. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA Ā· World journal of pediatrics : WJP Ā· 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  77. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q Ā· Clinical nutrition (Edinburgh, Scotland) Ā· 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  78. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y Ā· Pediatric gastroenterology, hepatology & nutrition Ā· 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  79. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q Ā· The American journal of clinical nutrition Ā· 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  80. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J Ā· Sleep medicine: X Ā· 2025
    Randomized trial80 participantsEnergy forMagnesium
  81. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E Ā· Journal of cachexia, sarcopenia and muscle Ā· 2024
    Cohort study81,524 participantsEnergy forMagnesium
  82. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D Ā· Lancet (London, England) Ā· 1991
    Randomized trial32 participantsEnergy forMagnesium
  83. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C Ā· Magnesium research Ā· 2008
    Narrative reviewEnergy forMagnesium
  84. [Efficacy of potassium N-acetylaminosuccinate (Cogitum) in the treatment of asthenic syndrome: results of double-blind placebo-controlled trial].
    Esin RG; Khayrullin IK; Esin OR; Fatykhova AF; Gismatullina EI; Isaeva YN Ā· Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Ā· 2023
    Randomized trial37 participantsEnergy forPotassium
  85. Human resting energy expenditure in relation to dietary potassium.
    DĆ©riaz O; ThĆ©riault G; LavallĆ©e N; Fournier G; Nadeau A; Bouchard C Ā· The American journal of clinical nutrition Ā· 1991
    Randomized trial8 participantsEnergy forPotassium
  86. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    LĆ³pez-MuƱoz P; Torres-Costoso AI; FernĆ”ndez-RodrĆ­guez R; GuzmĆ”n-PavĆ³n MJ; de Arenas-Arroyo SN; Basco-LĆ³pez JƁ; Reina-GutiĆ©rrez S Ā· Nutrients Ā· 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  87. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM Ā· Arthritis care & research Ā· 2016
    Randomized trial40 participantsEnergy forVitamin D
  88. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M Ā· Nutrients Ā· 2026
    Randomized trial91 participantsEnergy forVitamin D
  89. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S Ā· Reumatologia Ā· 2024
    Randomized trial68 participantsEnergy forVitamin D
  90. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E Ā· Science & sports Ā· 2022
    Randomized trial40 participantsEnergy forVitamin D
  91. Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.
    Nikkhah S; Dolatian M; Naghii MR; Zaeri F; Taheri SM Ā· Complementary therapies in clinical practice Ā· 2015
    Randomized trial113 participantsGeneral Health forBoron
  92. Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.
    Elewski BE; Aly R; Baldwin SL; GonzĆ”lez Soto RF; Rich P; Weisfeld M; Wiltz H; Zane LT; Pollak R Ā· Journal of the American Academy of Dermatology Ā· 2015
    Randomized trialGeneral Health forBoron
  93. The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.
    Toledo-Bahena ME; Bucko A; Ocampo-Candiani J; Herz-Ruelas ME; Jones TM; Jarratt MT; Pollak RA; Zane LT Ā· Journal of drugs in dermatology : JDD Ā· 2015
    Clinical trial336 participantsGeneral Health forBoron
  94. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).
    Henriksson R; Capala J; Michanek A; Lindahl SA; Salford LG; FranzĆ©n L; Blomquist E; Westlin JE; Bergenheim AT; Swedish Brain Tumour Study Group Ā· Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Ā· 2009
    Single-arm trial30 participantsGeneral Health forBoron
  95. Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1Ī², IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study
    Otilia-Constantina Rogoveanu, George Dan Mogosanu, Cornelia Bejenaru, Ludovic Everard Bejenaru, Octavian Croitoru, Johny Neamtu, Zbigniew Pietrzkowski, Tania Reyes-Izquierdo, Andrei Bita, Iulia Daria Scorei, Romulus Ion Scorei Ā· Biological Trace Element Research Ā· 2015
    Randomized trial78 participantsGeneral Health forBoron
  96. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z Ā· Nutrients Ā· 2022
    Cohort study55,569 participantsGeneral Health forFolate
  97. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC Ā· European journal of clinical nutrition Ā· 1998
    Randomized trial119 participantsGeneral Health forFolate
  98. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY Ā· The Journal of nutrition Ā· 2023
    Cohort study21,260 participantsGeneral Health forFolate
  99. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F Ā· Medicine Ā· 2024
    Systematic reviewGeneral Health forFolate
  100. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS Ā· Journal of public health (Oxford, England) Ā· 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  101. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ Ā· Anesthesiology Ā· 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  102. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S Ā· Lancet (London, England) Ā· 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  103. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY Ā· British journal of anaesthesia Ā· 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  104. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K Ā· American journal of kidney diseases : the official journal of the National Kidney Foundation Ā· 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  105. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH Ā· Reproductive biology and endocrinology : RB&E Ā· 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  106. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C Ā· The Cochrane database of systematic reviews Ā· 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  107. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A Ā· Neurogastroenterology and motility Ā· 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  108. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K Ā· Inflammopharmacology Ā· 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  109. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC Ā· International journal of environmental research and public health Ā· 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  110. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y Ā· PloS one Ā· 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  111. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY Ā· Nursing open Ā· 2022
    Randomized trial144 participantsGeneral Health forZinc
  112. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S Ā· The New England journal of medicine Ā· 1995
    Randomized trial937 participantsGeneral Health forZinc
  113. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group Ā· Archives of ophthalmology (Chicago, Ill. : 1960) Ā· 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  114. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R Ā· Scientific reports Ā· 2026
    Randomized trial84 participantsGeneral Health forZinc
  115. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A Ā· The journal of obstetrics and gynaecology research Ā· 2018
    Randomized trial142 participantsGeneral Health forZinc
  116. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y Ā· Stroke Ā· 2017
    Randomized trial20,702 participantsHeart Health forFolate
  117. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group Ā· Annals of internal medicine Ā· 2022
    Case-control study985 participantsHeart Health forFolate
  118. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS Ā· Critical reviews in food science and nutrition Ā· 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate
  119. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A Ā· Nutrition reviews Ā· 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  120. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M Ā· SAGE open medicine Ā· 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  121. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M Ā· Frontiers in nutrition Ā· 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  122. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; RodrĆ­guez-MorĆ”n M Ā· Journal of human hypertension Ā· 2009
    Randomized trial82 participantsHeart Health forMagnesium
  123. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Grƶber U; Predel HG; Reuter H Ā· International journal of clinical pharmacology and therapeutics Ā· 2024
    Randomized trial54 participantsHeart Health forMagnesium
  124. Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials.
    Poorolajal J; Zeraati F; Soltanian AR; Sheikh V; Hooshmand E; Maleki A Ā· PloS one Ā· 2017
    Meta-analysis1,213 participants23 studies pooledHeart Health forPotassium
  125. Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study.
    O'Donnell M; Mente A; Rangarajan S; McQueen MJ; O'Leary N; Yin L; Liu X; Swaminathan S; Khatib R; Rosengren A; Ferguson J; Smyth A; Lopez-Jaramillo P; Diaz R; Avezum A; Lanas F; Ismail N; Yusoff K; Dans A; Iqbal R; Szuba A; Mohammadifard N; Oguz A; Yusufali AH; Alhabib KF; Kruger IM; Yusuf R; Chifamba J; Yeates K; Dagenais G; Wielgosz A; Lear SA; Teo K; Yusuf S; PURE Investigators Ā· BMJ (Clinical research ed.) Ā· 2019
    Cohort study103,570 participantsHeart Health forPotassium
  126. Effect of Potassium Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis of Intervention Studies.
    D'Elia L; Cappuccio FP; Masulli M; La Fata E; Rendina D; Galletti F Ā· Nutrients Ā· 2023
    Meta-analysis332 participants5 studies pooledHeart Health forPotassium
  127. Effects of potassium supplementation on office, home, and 24-h blood pressure in patients with essential hypertension.
    Kawano Y; Minami J; Takishita S; Omae T Ā· American journal of hypertension Ā· 1999
    Randomized trial55 participantsHeart Health forPotassium
  128. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P Ā· European journal of nutrition Ā· 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  129. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM Ā· Frontiers in cardiovascular medicine Ā· 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  130. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T Ā· Asia Pacific journal of clinical nutrition Ā· 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  131. Influence of folic acid on postprandial endothelial dysfunction.
    Wilmink HW; Stroes ES; Erkelens WD; Gerritsen WB; Wever R; Banga JD; Rabelink TJ Ā· Arteriosclerosis, thrombosis, and vascular biology Ā· 2000
    Randomized trial20 participantsStress Relief forFolate
  132. The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial.
    Bahmani F; Karamali M; Shakeri H; Asemi Z Ā· Clinical endocrinology Ā· 2015
    Randomized trial69 participantsStress Relief forFolate
  133. Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.
    Taylor MJ; Carney SM; Goodwin GM; Geddes JR Ā· Journal of psychopharmacology (Oxford, England) Ā· 2004
    Meta-analysis247 participants3 studies pooledStress Relief forFolate
  134. Depressive symptoms and associated factors among women preparing for pregnancy: a population-based study from the Seoul metropolitan preconception health management program.
    Lee HJ; Shin W; Han JY; Choi HZ; Kang J; Woo SY Ā· BMC women's health Ā· 2026
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