Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials.
Fernández-San-MartÃn MI; Masa-Font R; Palacios-Soler L; Sancho-Gómez P; Calbó-Caldentey C; Flores-Mateo G · Sleep medicine · 2010
Meta-analysis18 studies pooledflagSleep Support forscienceValerian
- Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
Case-control study40 participantsflagSleep Support forscienceGABA
- Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
Ell J; Schmid SR; Benz F; Spille L · Journal of sleep research · 2024
Systematic review15 studies pooledflagSleep Support forscienceValerian
- Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
Randomized trial40 participantsflagSleep Support forscienceGABA
- Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
Randomized trial40 participantsflagSleep Support forscienceValerian
- Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
Randomized trial160 participantsflagSleep Support forscienceGABA
- Valerian for sleep: a systematic review and meta-analysis.
Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
Meta-analysis1,093 participants16 studies pooledflagSleep Support forscienceValerian
- Does valerian work for insomnia? An umbrella review of the evidence.
Valente V; Machado D; Jorge S; Drake CL; Marques DR · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
Systematic review8 studies pooledflagSleep Support forscienceValerian
- Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
Sateia MJ; Buysse DJ; Krystal AD; Neubauer DN; Heald JL · Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
Guideline / consensusflagSleep Support forscienceValerian
- Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
Randomized trial202 participantsflagSleep Support forscienceValerian
- Herbal medicine for insomnia: A systematic review and meta-analysis.
Leach MJ; Page AT · Sleep medicine reviews · 2016
Meta-analysis1,602 participants14 studies pooledflagSleep Support forscienceValerian
- Valerian for insomnia: a systematic review of randomized clinical trials.
Stevinson C; Ernst E · Sleep medicine · 2019
Systematic review9 studies pooledflagSleep Support forscienceValerian
- A systematic review of insomnia and complementary medicine.
Sarris J; Byrne GJ · Sleep medicine reviews · 2011
Systematic review20 studies pooledflagSleep Support forscienceValerian
- GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
Randomized trial30 participantsflagSleep Support flagStress Relief forscienceGABA
- Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
Randomized trial80 participantsflagSleep Support flagStress Relief forscienceValerian
- Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
Randomized trial40 participantsflagSleep Support forscienceValerian
- Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
Randomized trial63 participantsflagStress Relief forscienceGABA
- Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
Clinical trial30 participantsflagStress Relief forscienceGABA
- Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
Case-control study45 participantsflagStress Relief forscienceGABA
- Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
Randomized trial168 participantsflagStress Relief forscienceGABA
- Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
Randomized trial54 participantsflagStress Relief forscienceValerian
- Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
Systematic review327 participants12 studies pooledflagStress Relief forscienceValerian
- Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
Non-randomized trial54 participantsflagStress Relief forscienceValerian
- Stress-induced insomnia treated with kava and valerian: singly and in combination.
Wheatley D · Human psychopharmacology · 2019
Single-arm trial24 participantsflagStress Relief forscienceValerian