Ortho Sleep
AOR Advanced Orthomolecular Research Advanced
Ortho Sleep
4.1
★ ★ ★ ★ ★
(129 ratings)
Valerian 150 mg
Theanine 200 mg
5-HTP 100 mg
GABA 100 mg
Melatonin 3 mg
Score 78.0
A comprehensive sleep aid featuring a blend of GABA, L-Theanine, Melatonin, 5-HTP, Valerian, Passionflower, and Lemon Balm, designed for stress relief, mood support, and improved sleep quality. It offers effective dosages for key ingredients, but its price per serving is on the higher end.
Quantity: 60 Capsule(s)Servings size: 2 Capsule(s) (30 servings)
Selected goals:
Other goals:
Stress Relief
Mood Support
Sleep Support
Mental Focus
Brain Health
leaderboard Score 78.0
A comprehensive sleep aid featuring a blend of GABA, L-Theanine, Melatonin, 5-HTP, Valerian, Passionflower, and Lemon Balm, designed for stress relief, mood support, and improved sleep quality. It offers effective dosages for key ingredients, but its price per serving is on the higher end.
insights Analysis
Ortho Sleep by AOR Advanced Orthomolecular Research provides a synergistic blend of ingredients targeting relaxation and sleep. It contains GABA, L-Theanine, Melatonin, 5-HTP, Valerian, Passionflower, and Lemon Balm. The L-Theanine (200mg) and 5-HTP (100mg) dosages are particularly strong and align with research-backed amounts for their respective effects on relaxation and mood. Melatonin at 3mg is a standard and effective dose for sleep initiation. While Valerian (150mg) and Passionflower (32mg) are included, their doses are on the lower side compared to some standalone supplements, potentially limiting their full impact, although they still contribute to the overall calming effect. The inclusion of Lemon Balm further enhances the anxiolytic properties of the blend. Overall, this product offers a robust multi-ingredient approach to sleep and stress, though its higher cost per serving may be a consideration for some consumers.
- Contains a comprehensive blend of well-researched ingredients for sleep and relaxation.
- Provides effective dosages of L-Theanine (200mg) and 5-HTP (100mg) for mood and calm.
- Synergistic combination of ingredients that target multiple pathways for sleep and stress relief.
- The price per serving is notably higher than many comparable alternative products.
- Dosages for some herbal extracts like Passionflower and Valerian are relatively low, potentially offering less impact than higher-dosed alternatives.
- The oral bioavailability and effectiveness of supplemental GABA for crossing the blood-brain barrier are still subject to scientific debate.
- May cause drowsiness; avoid driving or operating heavy machinery after use.
- Consult a healthcare professional before use if pregnant, nursing, taking medication (especially antidepressants or sedatives), or have a medical condition.
- Not intended for long-term use; for occasional sleeplessness.
$35.16($1.17 per serving)
 iHerb | $ 35.16 | |
 Amazon | $ 35.16 | |
 Pure Formulas | $ 35.17 |
bolt Effectiveness for goals
This blend combines several ingredients known to support different aspects of sleep. Melatonin, 5-HTP, and Valerian are associated with sleep onset and quality, while GABA, L-Theanine, Passionflower, and Lemon Balm aim to promote relaxation and calmness. Together, they may help prepare the body for restful sleep.
Melatonin is a hormone central to regulating sleep, while L-5-Hydroxytryptophan (5-HTP) is a precursor to serotonin, which can then be converted to melatonin. This combination is designed to support the body's natural production of sleep-related compounds and directly supplement melatonin for sleep initiation.
GABA is an inhibitory neurotransmitter that helps calm nerve activity in the brain. L-Theanine, an amino acid, can increase levels of GABA and alpha brain waves, which are associated with a relaxed but alert state. Their combined presence may contribute to a greater sense of calm, which can be beneficial for sleep.
Valerian root is a widely studied herbal ingredient traditionally used to promote sleep and reduce the time it takes to fall asleep. It is believed to work by interacting with GABA receptors in the brain, contributing to its sedative effects and supporting deeper sleep.
Lemon Balm (Melissa officinalis) is an herb recognized for its anxiolytic and calming properties. It is often used to alleviate symptoms of stress and anxiety, which can interfere with sleep. Its presence aims to help soothe the nervous system, facilitating relaxation prior to bedtime.
schedule Dosage, timing & forms
Supplements formulated for sleep are typically recommended to be taken 30-60 minutes before your intended bedtime. This allows the ingredients time to be absorbed and begin working. Consistency in timing each night can also support a regular sleep cycle.
For a supplement containing 3mg of melatonin, it is commonly advised to take it approximately 30 minutes before you plan to go to sleep. This timing helps align the supplement's effects with the natural onset of sleep. Other ingredients like Valerian and L-Theanine also contribute to relaxation within this timeframe.
While these ingredients are generally well-tolerated, some individuals may experience mild next-day grogginess or residual sedation, especially when first starting. It is advisable to start with the recommended dose and assess individual response. Ensuring a full 7-8 hours of sleep can help mitigate this effect.
For many sleep supplements, taking them on an empty stomach or with a light snack is often suggested to potentially facilitate faster absorption. However, some individuals might prefer to take them with food to avoid any potential stomach discomfort. Always follow the specific instructions on the product label.
Many sleep supplements containing these ingredients are designed for occasional use or short-term support during periods of sleep difficulty. For prolonged daily use, especially with melatonin and valerian, it's generally recommended to consult a healthcare professional. Regular breaks can help assess ongoing need and effectiveness.
health_and_safety Safety & interactions
The combination of these ingredients may lead to common side effects such as drowsiness, dizziness, and mild gastrointestinal discomfort. Individuals might also experience vivid dreams or changes in sleep patterns. It is recommended to assess individual tolerance, especially when first starting use.
Yes, ingredients like Valerian, Passionflower, and GABA can enhance the effects of central nervous system depressants. This includes alcohol and sedative medications, potentially leading to increased drowsiness, dizziness, and impaired coordination. It is important to consult a healthcare professional before combining these substances.
L-5-HTP works by increasing serotonin levels in the brain. Combining it with selective serotonin reuptake inhibitors (SSRIs) or other antidepressant medications may lead to an excessive accumulation of serotonin, a condition known as serotonin syndrome. This serious interaction can cause symptoms such as confusion, rapid heart rate, and muscle rigidity.
Melatonin may potentially interact with certain medications. It could increase the effects of anticoagulant and antiplatelet drugs, thereby increasing the risk of bleeding. Additionally, melatonin might interfere with immunosuppressant therapy. Consulting a healthcare provider is advised if you are on such medications.
The safety of these specific ingredients, individually or in combination, during pregnancy or breastfeeding has not been definitively established through sufficient research. Due to a lack of comprehensive safety data, it is generally recommended that pregnant or breastfeeding individuals consult with a healthcare provider before using any supplements.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Lemon Balm (Melissa officinalis L.) aerial parts extract | 300 mg |
L-Theanine | 200 mg |
Valerian (Valeriana officinalis L.) root extract | 150 mg |
GABA | 100 mg |
L-5-Hydroxytryptophan | 100 mg |
Passionflower (Passiflora incarnata L.) aerial parts extract | 32 mg |
Melatonin | 3 mg |
Categories
Theanine 90.0
The 200mg of L-Theanine is an optimal dose, providing a calming effect without sedation, enhancing relaxation, and improving sleep quality, and it works synergistically with other ingredients without causing drowsiness.
5-HTP 85.0
At 100mg, the 5-HTP dosage is well-aligned with typical recommendations for mood support and as a precursor for serotonin, which then converts to melatonin, contributing effectively to both mood and sleep.
Melatonin 80.0
The 3mg dosage of melatonin is a commonly recommended and effective amount for initiating sleep without typically causing excessive grogginess, making it a reliable component for addressing sleep onset issues.
Goals
Sleep Support 90.0
The product combines multiple well-researched ingredients like melatonin, valerian, L-theanine, and 5-HTP, all known to promote sleep initiation and quality, offering a comprehensive approach to addressing various aspects of sleep difficulty.
Stress Relief 85.0
With L-theanine, GABA, valerian, passionflower, and lemon balm, this supplement includes several compounds recognized for their anxiolytic properties, which can help calm the nervous system and reduce feelings of stress and tension.
Mood Support 80.0
The inclusion of 5-HTP, a direct precursor to serotonin, is highly beneficial for mood regulation, and L-theanine can also contribute to a sense of calm and well-being, positively impacting mood.
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