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Ortho Sleep

AOR Advanced Orthomolecular Research Advanced
4.2
★ ★ ★ ★ ★
(149 ratings)
Theanine 200 mg
GABA 100 mg
5-HTP 100 mg
Melatonin 3 mg
Valerian 150 mg
Product Image
Score75
Meaningful theanine and lemon balm join melatonin, valerian, GABA, and 5-HTP in a coherent sleep blend. Cost and serotonin interactions are its main drawbacks.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Sleep Support
Stress Relief
Brain Health
Mood Support
Productivity Boost

Score 75

Meaningful theanine and lemon balm join melatonin, valerian, GABA, and 5-HTP in a coherent sleep blend. Cost and serotonin interactions are its main drawbacks.
How scoring works
$35.16($1.17 per serving)
iHerb
$ 35.16
Pure Formulas
$ 35.17
Amazon
$ 35.16
Report prices

Analysis

Lemon balm at 300 mg and L-theanine at 200 mg provide the strongest calming foundation. Valerian at 150 mg is lighter, while 3 mg melatonin directly supports sleep timing.

GABA and 5-HTP are each supplied at 100 mg, with smaller passionflower adding botanical breadth. Ingredient amounts and species are mostly clear, although active-marker percentages are not supplied.

Two capsules are manageable, but serving value is only modest. The combination suits stress-related sleep needs better than weight loss, focus, or daytime productivity.

Who is it for
  • Adults seeking nighttime sleep support
  • People who want several calming pathways in one formula
  • Users not taking serotonergic medicines
Best for
  • Bedtime relaxation
  • Sleep-onset support
  • Stress-related sleep difficulty

Pros

  • Provides 200 mg L-theanine
  • Includes 300 mg lemon balm
  • Uses a coherent set of bedtime ingredients
  • Clearly lists individual amounts

Cons

  • Serving value is modest
  • Valerian is lightly dosed
  • Botanical active-marker percentages are missing
  • Poor match for daytime productivity

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines.
  • Melatonin and the calming blend may cause next-day drowsiness or impaired alertness.
  • Alcohol, sedatives, and sleep medicines can add to the formula’s effects.

Nutrient quality

83 Highest impact

Specific botanical species improve identity, but marker percentages and extract ratios are not supplied; theanine, melatonin, lemon balm, and 5-HTP are useful, while valerian and passionflower are modest. Doses are mostly moderate, although multiple sedatives and 5-HTP create interaction concerns; the ingredients coherently cover sleep onset and relaxation; most actives have a clear nighttime purpose.

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Ingredient transparency

77 High impact

Every listed active has a specific amount; no proprietary blend hides key doses. Latin species and plant parts are often given, but potency standardization remains incomplete; serving directions and inactive ingredients are not included in the supplied details.

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Customer satisfaction

70 High impact

The supplied aggregate average is favorable, though no individual feedback is available; the large rating sample improves confidence in the aggregate average, but no individual feedback is supplied. Detailed feedback is absent, so repeated complaints cannot be assessed; real-world fit with the intended purpose remains uncertain.

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Value for money

66 High impact

The broad formula partly supports a premium cost; the cost per serving is high despite useful ingredient coverage. Most ingredients add relevant sleep support; several comparable sleep blends cost less per serving.

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Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A Goal FitB+ Strength of SupportA CoverageA Formula Quality
Melatonin · 3 mgTheanine · 200 mg

Melatonin directly supports circadian timing, while theanine, lemon balm, GABA, 5-HTP, and valerian address relaxation and sleep onset. Several key actives are supplied at meaningful, transparent amounts.

Valerian and passionflower are light, and the extracts lack full standardization details. The 5-HTP amount can interact with SSRIs, SNRIs, MAO inhibitors, and other serotonergic medicines, while the combined calming agents may cause next-day drowsiness.

Study evidence
5-HTP Supportive 1 study
GABA Supportive 4 studies
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Valerian Supportive 31 studies
Stress Relief
Stress Relief
Impact
Highest effect
A- Goal FitB+ Strength of SupportA- CoverageB+ Formula Quality
GABA · 100 mgTheanine · 200 mg

L-theanine, GABA, melatonin, valerian, and 5-HTP provide strong multi-pathway support for relaxation and sleep-related stress. Theanine is especially well dosed, while GABA and physiological-dose melatonin add complementary calming effects.

Valerian is below the preferred extract range and lacks active-marker standardization, but the overall blend retains useful depth. Melatonin and valerian may cause drowsiness, and 5-HTP can interact with serotonergic antidepressants.

Study evidence
5-HTP Supportive 18 studies
GABA Supportive 6 studies
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Valerian Supportive 18 studies
Brain Health
Brain Health
Impact
Highest effect
B+ Goal FitB+ Strength of SupportB+ CoverageA Formula Quality

L-theanine, melatonin, 5-HTP, valerian, GABA, lemon balm, and passionflower form a focused sleep and calming blend. Theanine and melatonin are supplied at evidence-aligned amounts.

Oral GABA and some botanicals have less consistent evidence, while 5-HTP can compound serotonin-related effects with serotonergic antidepressants. The formula supports brain health indirectly through sleep rather than improving daytime cognition.

Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Mood Support
Mood Support
Impact
High effect
B- Goal FitB Strength of SupportB- CoverageB Formula Quality
5-HTP · 100 mg

5-HTP directly supports serotonin production, while theanine, lemon balm, valerian, GABA, passionflower, and melatonin promote calm and sleep. Most core amounts are meaningful for a multi-ingredient nighttime formula.

The blend is weighted toward sedation and sleep rather than broad daytime mood support. 5-HTP may dangerously amplify serotonergic medicines, while stacked calming ingredients and melatonin can increase next-day drowsiness.

Study evidence
5-HTP Supportive 9 studies
GABA Supportive 12 studies
Theanine Supportive 12 studies
Valerian Supportive 17 studies
Productivity Boost
Productivity Boost
Impact
High effect
C- Goal FitB+ Strength of SupportC- CoverageC+ Formula Quality
Theanine · 200 mg

Theanine reaches a useful calming amount, but the formula is designed to promote sleep rather than daytime productivity. Melatonin, valerian, lemon balm, GABA, passionflower, and 5-HTP can impair alertness after use.

Better sleep may indirectly help next-day performance when insomnia is the limiting problem. The 5-HTP content can raise serotonin-related risk with SSRIs, SNRIs, or MAO inhibitors, and the sedating combination can impair driving.

Study evidence
Theanine Supportive 5 studies
Weight Loss
Weight Loss
Impact
Moderate effect
D- Goal FitB Strength of SupportC- CoverageA Formula Quality

Improved sleep may indirectly support appetite regulation, and the listed 5-HTP amount may influence serotonin-related cravings. Theanine, lemon balm, valerian, GABA, passionflower, and melatonin form a clear nighttime calming blend.

No ingredient directly promotes fat loss, thermogenesis, or muscle preservation. The 5-HTP can interact with serotonergic medicines, so users taking those medicines need product-specific medical guidance.

Study evidence
5-HTP Supportive 5 studies
Theanine Not classified

No linked studies yet.

Cognitive Support
Cognitive Support
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportC CoverageD+ Formula Quality
Theanine · 200 mg

L-theanine at 200 mg may support calm attention, while 5-HTP and GABA affect relaxation-related signaling. Valerian, lemon balm, passionflower, and melatonin make the product strongly sleep-oriented rather than cognition-oriented.

Several ingredients reach useful nighttime amounts, but sedation may impair alertness and mental performance. 5-HTP may interact with serotonin-raising medicines, and the combined sleep ingredients may add to drowsiness.

Study evidence
Theanine Supportive 25 studies

Ingredients

IngredientAmount per serving
Lemon Balm (Melissa officinalis L.) aerial parts extract
300 mg
L-Theanine
200 mg
Valerian (Valeriana officinalis L.) root extract
150 mg
GABA
100 mg
L-5-Hydroxytryptophan (Griffonia)
 100 mg
Passionflower (Passiflora incarnata L.) aerial parts extract
32 mg
Melatonin
3 mg
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
Theanine · 200 mg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

The active L-isomer and an optimal theanine dose are clearly disclosed. Generic sourcing leaves purity less certain than a branded form. Clinically dosed 5-HTP improves value, though it may compound the effects of serotonergic medicines.

View ingredientView products
GABA · 100 mg OverallScore70
B- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD- Value

The 100 mg GABA dose is transparent and reasonable within a multi-ingredient sleep blend, but it uses an unbranded standard form. Capsule delivery is conventional, and the serving cost is high relative to the GABA amount. Melatonin, valerian, and 5-HTP may cause drowsiness, while 5-HTP warrants care with serotonergic medicines.

View ingredientView products
5-HTP (Griffonia) · 100 mg OverallScore58
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value

The serving provides the collection's target 5-HTP amount from a named Griffonia source. Vegetarian capsules are practical, but the extract standardization and specific serotonin-medication warning are not supplied. The formula is expensive for its 5-HTP content, and its melatonin plus several calming ingredients may increase next-day drowsiness in sensitive users.

View ingredientView products
Loading alternative details
77 Performance

Sleep Support

The Vitamin Shoppe
<p>Useful amounts of L-theanine, GABA, melatonin, and 5-HTP create a strong sleep-oriented blend. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
77 Performance

Lights Out Sleep

ALLMAX
<p>A varied sleep blend provides useful valerian, GABA, melatonin, and active vitamin B6. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
76 Performance

Best-Rest Formula

Pure Encapsulations
<p>Branded L-theanine, active vitamin B6, substantial GABA, valerian, and several calming herbs create a technically strong sleep blend. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
87 Budget

Sleep Regimen 3-in-1

NOW
<p>Melatonin, L-theanine, and Griffonia-derived 5-HTP create a focused, fully disclosed sleep formula with excellent serving value. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
79 Budget

Superior Sleep

Doctor's Best
<p>Ashwagandha, theanine, GABA, melatonin, and 5-HTP are all supplied at meaningful amounts for sleep support. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
82 Budget

Tranquil Sleep

Natural Factors Stress-Relax
<p>Branded Suntheanine, physiological melatonin, and Griffonia-derived 5-HTP make a coherent bedtime blend in an enteric-coated softgel. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
72 Value

Power to Sleep PM

Irwin Naturals
<p>Valerian, ashwagandha, hops, lemon balm, passionflower, and melatonin create broad nighttime support. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
82 Value

Tranquil Sleep

Natural Factors Stress-Relax
<p>Branded Suntheanine, physiological melatonin, and Griffonia-derived 5-HTP create a well-defined sleep formula in an enteric-coated softgel. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
69 Value

Sleep Support

Bluebonnet Targeted Choice
<p>Theanine, valerian, tart cherry, passionflower, 5-HTP, and chamomile form a coherent but lightly dosed sleep blend. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  2. Does valerian work for insomnia? An umbrella review of the evidence.
    Valente V; Machado D; Jorge S; Drake CL; Marques DR · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
    Systematic review8 studies pooledSleep Support forValerian
  3. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  4. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  5. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  6. Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
    Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
    Meta-analysis1,998 participants34 studies pooledSleep Support forMelatonin
  7. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  8. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsSleep Support Brain Health Cognitive Support forTheanine
  9. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  10. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsStress Relief Mood Support forTheanine
  11. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  12. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  13. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  14. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  15. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  16. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  17. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  18. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support forTheanine
  19. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  20. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Productivity Boost forTheanine
  21. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  22. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support forTheanine
  23. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  24. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  25. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  26. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  27. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  28. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsMood Support Stress Relief forGABA
  29. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  30. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  31. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  32. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  33. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  34. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  35. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine Stress Relief forGABA
  36. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  37. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsMood Support Sleep Support Stress Relief forValerian
  38. Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
    Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
    Meta-analysis12 studies pooledMood Support forValerian
  39. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
    Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
    Meta-analysis6,894 participants60 studies pooledMood Support forValerian
  40. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
    Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
    Randomized trial20 participantsMood Support forValerian
  41. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledMood Support Stress Relief forValerian
  42. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  43. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsProductivity Boost Stress Relief forTheanine
  44. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  45. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost forTheanine
  46. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  47. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  48. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  49. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  50. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  51. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  52. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  53. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  54. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  55. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  56. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
    Randomized trial40 participantsSleep Support forValerian
  57. Valerian for sleep: a systematic review and meta-analysis.
    Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
    Meta-analysis1,093 participants16 studies pooledSleep Support forValerian
  58. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  59. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  60. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  61. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  62. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  63. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  64. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  65. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
    Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
    Randomized trial202 participantsStress Relief forMelatonin
  66. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
    Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
    Randomized trial90 participantsStress Relief forMelatonin
  67. Melatonin for pre- and postoperative anxiety in adults.
    Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
    Meta-analysis774 participants12 studies pooledStress Relief forMelatonin
  68. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
    Meta-analysis441 participants5 studies pooledStress Relief forMelatonin
  69. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
    Randomized trial88 participantsStress Relief forMelatonin
  70. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  71. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
    Randomized trial54 participantsStress Relief forValerian
  72. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
  73. Stress-induced insomnia treated with kava and valerian: singly and in combination.
    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian
  74. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  75. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  76. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  77. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  78. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP