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Insomnitol

Designs for Health
4.7
★ ★ ★ ★ ★
(49 ratings)
Theanine 100 mg
GABA 100 mg
Valerian 400 mg
5-HTP 100 mg
Product Image
Score72
A broad, well-dosed mix of melatonin, valerian, branded GABA, theanine, and 5-HTP offers strong bedtime support. High cost, additive drowsiness, and serotonin interactions are important trade-offs.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Sleep Support
Mood Support
Brain Health
Stress Relief

Score 72

A broad, well-dosed mix of melatonin, valerian, branded GABA, theanine, and 5-HTP offers strong bedtime support. High cost, additive drowsiness, and serotonin interactions are important trade-offs.
How scoring works
$55.99($1.86 per serving)
Pure Formulas
$ 55.99
iHerb
$ 55.99
Report prices

Analysis

Melatonin at 3 mg provides direct sleep-timing support, while 400 mg valerian, passionflower, lemon balm, and chamomile address relaxation through several botanical pathways. Active compounds are named for the main herbs, although their standardization percentages are not shown.

PharmaGABA, L-theanine, and 5-HTP are each supplied at 100 mg, with active vitamin B6 supporting neurotransmitter metabolism. The combination is substantial for bedtime use but may feel stronger than necessary for people who need only mild help.

Two capsules are convenient, but the serving value is weak. The formula fits persistent nighttime relaxation needs better than weight loss, mental focus, or daytime mood support.

Who is it for
  • Adults seeking nighttime sleep support
  • People who want several calming pathways in one formula
  • Users not taking serotonin-raising medicines
Best for
  • Bedtime relaxation
  • Sleep-onset support
  • Multi-ingredient support for stress-related sleep difficulty

Pros

  • Combines several meaningful sleep ingredients
  • Uses branded PharmaGABA
  • Includes active vitamin B6
  • Names marker compounds for the main calming herbs

Cons

  • Serving value is weak
  • Botanical marker percentages are missing
  • The long formula may be more sedating than needed
  • Poor fit for daytime focus or productivity

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines because serotonin effects can become excessive.
  • Melatonin, valerian, GABA, and the calming herbs may cause pronounced drowsiness; do not drive after use.
  • Alcohol, sedatives, and sleep medicines can add to the formula’s sedating effects.

Nutrient quality

88 Highest impact

Active vitamin B6 and branded GABA support good ingredient quality, while several botanical marker strengths are not quantified; the major sleep ingredients are supplied in plausible and clearly stated amounts. The doses are generally reasonable, although the many calming actives may produce additive sedation; the ingredient set directly covers sleep onset and relaxation through several complementary pathways; nearly every listed ingredient has a clear sleep or calming role.

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Ingredient transparency

77 High impact

Every listed active has a specific amount; no proprietary blend hides key doses. Most ingredients use specific forms or active markers, though several extracts lack standardized percentages; serving directions and inactive ingredients are not included in the supplied details.

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Customer satisfaction

65 High impact

The supplied aggregate average is very favorable, though no individual feedback is available; the rating sample is moderate, but no individual feedback is supplied. Detailed feedback is absent, so repeated complaints cannot be assessed; real-world fit with the intended purpose remains uncertain.

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Value for money

50 Lower impact

Strong formulation quality partly supports the premium positioning, but the cost remains high; the serving provides meaningful doses but is expensive for routine nightly use. The broad blend contains few obvious low-value additions; comparable sleep formulas often provide similar core actives at a lower serving cost.

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Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A Goal FitA- Strength of SupportA CoverageB+ Formula Quality
Melatonin · 3 mgTheanine · 100 mg

Melatonin provides direct circadian support, while GABA, L-theanine, 5-HTP, valerian, passionflower, lemon balm, and chamomile address several relaxation pathways. Most actives have substantial disclosed amounts.

The long combination can produce additive drowsiness, and 5-HTP should not be combined with serotonergic medicines. The formula is comprehensive, although missing botanical marker percentages limit full quality assessment.

Study evidence
5-HTP Supportive 1 study
GABA Supportive 4 studies
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Valerian Supportive 31 studies
Vitamin B6 Disputed 7 studies
Mood Support
Mood Support
Impact
Highest effect
B Goal FitA- Strength of SupportA- CoverageB Formula Quality
Vitamin B6 · 10 mg5-HTP · 100 mg

5-HTP, theanine, branded GABA, and several calming herbs provide broad relaxation and sleep support with some mood relevance. The formula is more strongly sedating than mood-stabilizing, so daytime use may be impractical.

Most lead ingredients reach useful amounts and several botanical markers are identified. Combined melatonin, valerian, GABA, and calming herbs may cause drowsiness, while 5-HTP can interact with serotonergic medicines.

Study evidence
5-HTP Supportive 9 studies
GABA Supportive 12 studies
Theanine Supportive 12 studies
Valerian Supportive 17 studies
Brain Health
Brain Health
Impact
Highest effect
B- Goal FitA- Strength of SupportB+ CoverageA- Formula Quality
Vitamin B6 · 10 mg

Melatonin, valerian, PharmaGABA, theanine, and calming botanicals support sleep, which can indirectly benefit cognition and recovery. The formula uses several standardized or branded ingredients at meaningful amounts.

It is a sleep product rather than a daytime cognitive enhancer, and the combined sedating ingredients can impair alertness after dosing. The 5-HTP should not be combined casually with serotonergic medicines such as SSRIs or MAO inhibitors because serotonin effects can add up.

Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Stress Relief
Stress Relief
Impact
Highest effect
B+ Goal FitB+ Strength of SupportA- CoverageC+ Formula Quality
GABA · 100 mgVitamin B6 · 10 mgTheanine · 100 mg

Valerian, lemon balm, passionflower, chamomile, theanine, GABA, 5-HTP, and melatonin provide broad nighttime calming support. Several ingredients reach plausible amounts and named active markers improve transparency.

The many sedative ingredients create overlap and may cause next-day drowsiness in sensitive users. The 5-HTP warrants caution with serotonergic medicines, while melatonin and the calming herbs may add to other sedatives.

Study evidence
5-HTP Supportive 18 studies
GABA Supportive 6 studies
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Valerian Supportive 18 studies
Mental Focus
Mental Focus
Impact
Moderate effect
D- Goal FitB Strength of SupportC- CoverageD+ Formula Quality
Vitamin B6 · 10 mgTheanine · 100 mg

L-theanine may support calm attention, but GABA, 5-HTP, and sleep-oriented ingredients shift the formula toward nighttime relaxation. The combination is poorly suited to users seeking alert, productive focus.

Key amounts and active forms are clearly disclosed, including PharmaGABA and active vitamin B6. 5-HTP should not be combined with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines because excessive serotonin can cause a serious reaction.

Study evidence
Theanine Supportive 19 studies
Vitamin B6 Disputed 6 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
F Goal FitB- Strength of SupportF CoverageB+ Formula Quality
Vitamin B6 · 10 mgTheanine · 100 mg

L-theanine may support calm attention, but valerian, 5-HTP, GABA, and melatonin make the formula primarily sedating. The ingredients are better supported for sleep than for memory or daytime cognition.

Several sleep actives are meaningfully dosed for the nighttime purpose. Sleep and relaxation pathways are covered without direct cognitive enhancement.

Study evidence
Theanine Supportive 25 studies

Ingredients

IngredientAmount per serving
Vitamin B-6 (Pyridoxal 5-Phosphate)
 10 mg
Valerian (Valerenic Acid)
 400 mg
Passion Flower (Flavonoids)
 200 mg
Lemon Balm (Rosmarinic Acid)
 200 mg
German Chamomile (Apigenin)
 200 mg
gamma-Aminobutyric acid (PharmaGABA(TM))
 100 mg
L-Theanine
100 mg
5-HTP
100 mg
Melatonin
3 mg
Gluten Free Adults 18–50
Report overview
Theanine · 100 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

A clearly disclosed 100 mg L-theanine dose falls within the preferred range for relaxation and focus support. The ingredient is the active L-isomer, although no branded source or added purity evidence is provided. Cost is high for the theanine amount, but meaningful doses of 5-HTP and branded GABA improve the broader formula's value.

View ingredientView products
GABA (PharmaGABA(TM)) · 100 mg OverallScore78
A Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD- Value

Branded PharmaGABA supplies a clearly disclosed 100 mg dose suited to a multi-ingredient sleep blend. Standard capsules are practical, and the formula pairs GABA with valerian, passionflower, lemon balm, chamomile, theanine, 5-HTP, and melatonin. The serving is expensive, while melatonin and 5-HTP warrant added care for people sensitive to sedatives or using serotonergic medicines.

View ingredientView products
Valerian (Valerenic Acid) · 400 mg OverallScore65
C- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The 400 mg valerian amount fits a useful range, but the label does not state a standardized valerenic-acid percentage or extract ratio. Capsules contain the herb's strong odor well, while the high serving cost weakens value. Melatonin, 5-HTP, GABA, theanine, and several calming herbs may increase drowsiness, and 5-HTP warrants caution with serotonergic medicines.

View ingredientView products
Loading alternative details
83 Performance

ZenMind

NutriCology
<p>Branded L-theanine and a substantial GABA amount form a focused relaxation stack with fully disclosed doses. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
76 Performance

Best-Rest Formula

Pure Encapsulations
<p>Branded L-theanine, active vitamin B6, substantial GABA, valerian, and several calming herbs create a technically strong sleep blend. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
75 Performance

Ortho Sleep

AOR Advanced Orthomolecular Research Advanced
<p>A broad mix of sleep ingredients offers strong pathway coverage with clearly disclosed amounts. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
78 Budget

Sleep

NOW
<p>Substantial valerian, hops, passionflower, and GABA create a focused nighttime calming blend. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
77 Budget

Lights Out Sleep

ALLMAX
<p>A varied sleep blend provides useful valerian, GABA, melatonin, and active vitamin B6. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
77 Budget

Sleep Support

The Vitamin Shoppe
<p>Useful amounts of L-theanine, GABA, melatonin, and 5-HTP create a strong sleep-oriented blend. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
75 Value

5-HTP 100 mg

Solgar
<p>A full 5-HTP amount is supported by active vitamin B6, magnesium, and valerian for mood and sleep-related use. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
74 Value

Chewable GABA

NOW
<p>A substantial GABA amount anchors the calming chewable, while taurine, inositol, and L-theanine provide only modest support. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
71 Value

PM Formula

Nature's Way
<p>Valerian, hops, theanine, and black cohosh form a coherent nighttime relaxation formula. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  2. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  3. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  4. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsSleep Support Brain Health Cognitive Support forTheanine
  5. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  6. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
    Randomized trial54 participantsStress Relief forValerian
  7. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
    Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
    Randomized trial20 participantsStress Relief Mood Support forValerian
  8. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  9. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  10. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  11. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  12. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  13. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  14. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  15. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  16. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus forTheanine
  17. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  18. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  19. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Stress Relief forTheanine
  20. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  21. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort.
    Deijen JB; van der Beek EJ; Orlebeke JF; van den Berg H · Psychopharmacology · 1995
    Randomized trial76 participantsMental Focus forVitamin B6
  22. The effect of vitamin B6 on cognition.
    Malouf R; Grimley Evans J · The Cochrane database of systematic reviews · 2004
    Systematic review109 participants2 studies pooledMental Focus forVitamin B6
  23. Antiemetic use during pregnancy and child neurodevelopment: population-based birth cohort study.
    Cho Y; Choi EY; Han JY; Kim H; Choe YJ; Shin JY · BMC medicine · 2025
    Cohort study630,904 participantsMental Focus forVitamin B6
  24. A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
    Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
    Randomized trial44 participantsMental Focus forVitamin B6
  25. B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial
    Tammy M Scott, Graham Rogers, Daniel E Weiner, Kathryn Livingston, Jacob Selhub, Paul F Jacques, Irwin H Rosenberg, Aron M Troen · The Journal of Prevention of Alzheimer's Disease · 2017
    Randomized trial584 participantsMental Focus forVitamin B6
  26. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  27. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  28. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  29. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  30. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  31. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsMood Support Stress Relief forGABA
  32. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  33. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  34. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  35. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  36. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  37. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  38. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  39. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine Stress Relief forGABA
  40. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  41. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsMood Support Sleep Support Stress Relief forValerian
  42. Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
    Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
    Meta-analysis12 studies pooledMood Support forValerian
  43. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
    Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
    Meta-analysis6,894 participants60 studies pooledMood Support forValerian
  44. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledMood Support Stress Relief forValerian
  45. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  46. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  47. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  48. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  49. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  50. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  51. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  52. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  53. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  54. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  55. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  56. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  57. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
    Randomized trial40 participantsSleep Support forValerian
  58. Valerian for sleep: a systematic review and meta-analysis.
    Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
    Meta-analysis1,093 participants16 studies pooledSleep Support forValerian
  59. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  60. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  61. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  62. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  63. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  64. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  65. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  66. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  67. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  68. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  69. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  70. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  71. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
    Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
    Randomized trial202 participantsStress Relief forMelatonin
  72. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
    Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
    Randomized trial90 participantsStress Relief forMelatonin
  73. Melatonin for pre- and postoperative anxiety in adults.
    Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
    Meta-analysis774 participants12 studies pooledStress Relief forMelatonin
  74. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
    Meta-analysis441 participants5 studies pooledStress Relief forMelatonin
  75. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
    Randomized trial88 participantsStress Relief forMelatonin
  76. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  77. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
  78. Stress-induced insomnia treated with kava and valerian: singly and in combination.
    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian