Product Image

2-in-1 Kidney & Liver Super Cleanse

Irwin Naturals
4.5
★ ★ ★ ★ ★
(1347 ratings)
Milk Thistle 270 mg
Stinging Nettle 150 mg
Vitamin B12 250 mcg
Vitamin B6 15 mg
European Elder 65 mg
EPA (Eicosapentaenoic Acid) 288 mg
Fish Oil 1600 mg
Product Image
Score62
A credible milk-thistle-centered cleanse blend with broad urinary support, offset by modest omega-3s and ingredients that are not well suited to prolonged use.
How scoring works
Quantity:60 Liquid(s) • (20 servings)
Goals:
Detoxification

Score 62

A credible milk-thistle-centered cleanse blend with broad urinary support, offset by modest omega-3s and ingredients that are not well suited to prolonged use.
How scoring works
$18.95($0.94 per serving)
Amazon
$ 18.95
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$ 24.99
Pure Formulas
$ 24.99
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$ 24.99
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Analysis

Milk thistle supplies a stated silymarin amount, and artichoke adds a complementary liver-oriented botanical. Cranberry, nettle, corn silk, dandelion, and uva ursi broaden the urinary focus, while several vitamins and minerals provide secondary nutritional support.

Fish oil supplies separately listed EPA and DHA, but their combined amount and concentration are modest for a dedicated omega-3 product. N-acetyl cysteine is lightly dosed, and several botanicals lack extraction ratios or active-marker standardization.

The formula may fit short-term organ-focused use by adults who understand its long ingredient list. Uva ursi and multiple diuretic herbs make routine prolonged use a poor match, particularly for people with kidney disease or those using diuretic medicines.

Who is it for
  • Adults seeking short-term liver and urinary support
  • Users who want milk thistle with disclosed silymarin
Best for
  • Short-term organ-focused supplementation
  • Milk thistle and artichoke support

Pros

  • Silymarin amount is disclosed
  • EPA and DHA are listed separately
  • Uses methylcobalamin and L-selenomethionine

Cons

  • Omega-3 concentration is low
  • Many botanicals lack standardization
  • Several supporting nutrients are lightly dosed

Warnings

  • Uva ursi and multiple diuretic herbs make prolonged use unsuitable, especially for people with kidney disease.
  • Nettle, corn silk, and dandelion may add to the effects of diuretic medicines and increase fluid loss.
  • Fish oil may increase bleeding tendency with anticoagulant or antiplatelet medicines.
  • Black pepper extract can increase absorption of some medicines and alter their effects.

Nutrient quality

58 Moderate impact

Several useful nutrient forms and disclosed silymarin support the organ-focused theme. Modest omega-3s, tiny NAC, and many low-dose botanicals create shallow and uneven coverage.

Ingredient transparency

70 High impact

Many active weights are stated and no large proprietary blend hides the formula. Null entries, missing amounts, uncertain fish-oil form, and absent inactive ingredients make the long panel hard to judge.

Customer satisfaction

70 High impact

The aggregate rating is favorable and supported by extensive feedback volume. No detailed comments are supplied to reveal repeated tolerance or performance issues.

Value for money

46 Lower impact

The broad formula provides several potentially useful actives, but the serving cost is high. Numerous token additions and weak fish-oil potency make it less competitive than focused organ-support products.

Report analysis

Goals

Detoxification
Detoxification
Impact
High effect
B+ Goal FitC+ Strength of SupportB CoverageC Formula Quality
Vitamin B12 · 250 mcgVitamin B6 · 15 mgSelenium · 50 mcgMagnesium · 12.5 mgMilk Thistle · 270 mgZinc · 7.5 mgVitamin C · 50 mg

Milk thistle with disclosed silymarin, artichoke, antioxidant nutrients, and a small amount of N-acetyl cysteine provide direct liver-support activity. The kidney-oriented botanicals broaden elimination support but do not all have strong evidence for systemic detoxification.

Milk thistle is the strongest component, while N-acetyl cysteine is too small to provide robust glutathione precursor support. Uva ursi and several diuretic herbs make prolonged use a poor fit, particularly for people with kidney disease.

Study evidence
Milk Thistle Supportive 46 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Moderate effect
C+ Goal FitC- Strength of SupportC CoverageC- Formula Quality
Vitamin D · 4 mcgFish Oil · 1600 mgVitamin C · 50 mg

EPA, DHA, nettle, ginger, vitamin C, zinc, and selenium provide several anti-inflammatory and antioxidant pathways. The fish oil offers the clearest evidence-based contribution.

Combined EPA and DHA are moderate, while ginger has no disclosed amount and the broader cleanse blend is difficult to assess. The kidney-and-liver positioning is broader than the formula’s anti-inflammatory depth.

Study evidence
Fish Oil Supportive 68 studies
Ginger Supportive 30 studies
Selenium Supportive 34 studies
Stinging Nettle Supportive 5 studies
Vitamin C Supportive 50 studies
Zinc Supportive 64 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
C Goal FitC Strength of SupportC- CoverageD Formula Quality
Potassium · 25 mgMagnesium · 12.5 mgVitamin D · 4 mcgFish Oil · 1600 mgSelenium · 50 mcgVitamin B12 · 250 mcgVitamin B6 · 15 mgVitamin C · 50 mg

Fish oil supplies separately stated EPA and DHA for basic lipid and inflammatory-pathway support. Clear fatty-acid amounts are more informative than a generic fish-oil total.

The combined EPA and DHA amount is modest for targeted triglyceride support, and the molecular form and oxidation testing are not disclosed. Most of the formula serves a kidney and liver cleanse concept rather than cardiovascular health.

Study evidence
Fish Oil Supportive 185 studies
Heart Health
Heart Health
Impact
Moderate effect
C+ Goal FitC- Strength of SupportC- CoverageF Formula Quality
Magnesium · 12.5 mgEPA (Eicosapentaenoic Acid) · 288 mgVitamin B12 · 250 mcgVitamin B6 · 15 mgVitamin D · 4 mcg

Disclosed EPA and DHA provide a credible cardiovascular pathway within a kidney-and-liver formula. Their combined amount is modest compared with a dedicated omega-3 product.

The many botanicals mainly serve detoxification and urinary goals rather than heart health. Fish-oil form and purity testing are not stated, while the long ingredient list dilutes the otherwise relevant omega-3 contribution.

Study evidence
General Health
General Health
Impact
Moderate effect
C- Goal FitD+ Strength of SupportC CoverageD+ Formula Quality
Vitamin B12 · 250 mcgVitamin D · 4 mcgMagnesium · 12.5 mgFish Oil · 1600 mgSelenium · 50 mcgZinc · 7.5 mgVitamin C · 50 mg

Fish oil, selected vitamins, minerals, and botanicals offer some support for antioxidant defenses and organ-focused wellness. Methylcobalamin and L-selenomethionine are useful forms, but the formula is built around a narrow cleanse concept rather than broad daily nutrition.

EPA and DHA are low, several nutrients are token additions, and many botanical extracts lack strong relevance to foundational health. The product fits short-term organ-focused use better than a comprehensive general-health plan.

Study evidence
Fish Oil Supportive 61 studies
Magnesium Supportive 114 studies
Vitamin B12 Adverse 66 studies
Vitamin D Supportive 115 studies
Energy
Energy
Impact
Moderate effect
D+ Goal FitC Strength of SupportD- CoverageD+ Formula Quality
Vitamin D · 4 mcgMagnesium · 12.5 mgVitamin B12 · 250 mcgFish Oil · 1600 mgPotassium · 25 mg

Vitamin B12 reaches the focused target, but the formula is designed for kidney and liver cleansing rather than energy. Magnesium is minimal and no caffeine, creatine, CoQ10, or substantial adaptogen is present.

B12 form details are incomplete, while many botanical amounts do not establish reliable energy support. The product has limited fit for an energy goal despite one useful metabolic nutrient.

Study evidence
Magnesium Supportive 4 studies
Vitamin B12 Disputed 14 studies

Ingredients

IngredientAmount per serving
Calories
30 Calorie(s)
Total Fat
2 Gram(s)
Saturated Fat
0.5 Gram(s)
Cholesterol
15 mg
Total Carbohydrates
3 Gram(s)
Protein
1 Gram(s)
Vitamin C
50 mg
Vitamin D
4 mcg
Vitamin B6
15 mg
Vitamin B12
250 mcg
Magnesium
12.5 mg
Zinc
7.5 mg
Selenium
50 mcg
Potassium
25 mg
Fish Oil
1600 mg
Eicosapentaenoic Acid
288 mg
Docosahexaenoic Acid
192 mg
Milk Thistle seed extract
270 mg
Silymarin
121.5 mg
Pacran SP Cranberry (Vaccinium macrocarpon) powder
250 mg
Artichoke leaf extract
187.5 mg
Stinging Nettle leaf extract
150 mg
Barberry Root Extract
100 mg
Corn Silk extract
100 mg
European Elder fruit extract
65 mg
Dandelion Leaf Extract
50 mg
Uva Ursi leaf extract
50 mg
N-Acetyl-Cysteine
45 mg
Reishi Mushroom Fruiting Body Extract
15 mg
BioPerine Complex
3 mg
Bioperine
0 NP
Ginger Rhizome Extract
0 NP
Adults 18–50 Women
Report overview
Milk Thistle · 270 mg OverallScore68
C+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD- Value
A seed extract delivers a clearly stated 121.5 mg of silymarin per serving. Fish-oil liquid softgels may improve solubility, although the active dose is slightly below the preferred range. The broader cleanse formula offers some quality justification, but milk-thistle value remains limited.
View ingredientView products
Vitamin B12 · 250 mcg OverallScore62
A- Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyF Value

The label indicates methylcobalamin, a bioactive B12 form, and provides the total amount. A swallowed softgel offers standard absorption and the serving sits at the low edge of a moderate dose. The broad combination formula is costly when measured only by its B12 content.

View ingredientView products
Stinging Nettle · 150 mg OverallScore62
C- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD- Value

Leaf extract is clearly specified, though its role in a broad kidney and liver formula is not well defined. The extract has no concentration ratio or active-marker standardization, while the amount falls near the collection median and is disclosed separately. The serving offers modest value because its cost is high relative to the nettle potency provided.

View ingredientView products
Loading alternative details
87 Performance

Omega-3

Solgar
The concentrated serving supplies 1,008 mg EPA and 756 mg DHA, greatly improving the original’s omega-3 depth for heart and anti-inflammatory support. Mixed tocopherols aid oxidation control, although fish source, molecular form, purification, and independent testing remain unclear.
83 Performance

Super Omega-3

Life Extension
Substantial EPA and DHA are paired with quantified olive polyphenols and sesame lignans, giving the formula more focused cardiovascular and antioxidant support than the original’s crowded blend. A four-softgel serving is less convenient, and oil-quality documentation is incomplete.
84 Performance

Alaska Wild Fish Oil Mega Omega-3

21st Century
The concentrated, EPA-forward serving provides 965 mg EPA and 385 mg DHA, offering much deeper omega-3 support than the original. Antioxidant protection, molecular form, fish species, and independent purity testing are not disclosed.
76 Budget

Omega-3 Fish Oil 1000 mg Lemon

Natrol
Clearly listed EPA and DHA preserve part of the original’s omega-3 coverage at a much lower serving cost. The 180 mg EPA and 120 mg DHA amounts are modest, and oil form, purification, and oxidation protection are not disclosed.
79 Budget

Omega-3 Fish Oil with Vitamin D 1000 mg Lemon Flavored

Swanson
Vitamin D3 adds useful general-health breadth while the disclosed EPA and DHA maintain part of the original’s cardiovascular focus at a lower serving cost. The omega-3 amounts remain modest, and purification, molecular form, and independent testing are not provided.
70 Budget

Omega-3 Salmon Oil

Bluebonnet
A simple fish-oil formula retains EPA and DHA coverage with favorable serving economics compared with the original. The active amounts are modest and dilute, while oxidation protection, molecular form, purification, and independent testing are not disclosed.
84 Value

Mega EPA/DHA

Life Extension
A substantial 720 mg EPA and 480 mg DHA serving gives stronger active depth and a better value trade-off than the original. Natural vitamin E supports oxidation control, but fish species, molecular form, purification, and independent testing are not disclosed.
80 Value

Super Omega-3

Country Life
The focused serving provides 400 mg EPA and 200 mg DHA from named small-fish sources, improving ingredient clarity and omega-3 efficiency over the original’s broad blend. Molecular form, purification, oxidation protection, and independent testing remain unknown.
82 Value

Extreme Omega 2400 mg Lemon Natural Flavor

Natrol
A substantial 646 mg EPA and 430 mg DHA serving with natural vitamin E combines focused support with favorable serving economics. The fish source, molecular form, purification process, and independent testing are not disclosed.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  3. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  4. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  5. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  6. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  7. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  8. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  9. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  10. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  11. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  12. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  13. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  14. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  15. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  16. The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis.
    Mazidi M; Gao HK; Rezaie P; Ferns GA · Food & nutrition research · 2022
    Meta-analysis9 studies pooledAnti-Inflammatory Support forGinger
  17. Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials.
    Musazadeh V; Morvaridi M; Hosseini-Roknabadi SM; Mahmoudinezhad M; Jafari A; Shidfar F · Diabetology & metabolic syndrome · 2026
    Meta-analysis43,570 participants36 studies pooledAnti-Inflammatory Support forGinger
  18. Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial.
    Mozaffari-Khosravi H; Naderi Z; Dehghan A; Nadjarzadeh A; Fallah Huseini H · Journal of nutrition in gerontology and geriatrics · 2017
    Randomized trial120 participantsAnti-Inflammatory Support forGinger
  19. Effects of Ginger Supplementation on Markers of Inflammation and Functional Capacity in Individuals with Mild to Moderate Joint Pain.
    Broeckel J; Estes L; Leonard M; Dickerson BL; Gonzalez DE; Purpura M; Jäger R; Sowinski RJ; Rasmussen CJ; Kreider RB · Nutrients · 2025
    Randomized trial30 participantsAnti-Inflammatory Support forGinger
  20. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis.
    Aryaeian N; Shahram F; Mahmoudi M; Tavakoli H; Yousefi B; Arablou T; Jafari Karegar S · Gene · 2019
    Randomized trial70 participantsAnti-Inflammatory Support forGinger
  21. Selenium and the course of mild Graves' orbitopathy.
    Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
    Randomized trial159 participantsAnti-Inflammatory Support forSelenium
  22. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsAnti-Inflammatory Support forSelenium
  23. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
    Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
    Randomized trial60 participantsAnti-Inflammatory Support forSelenium
  24. The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
    Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
    Meta-analysis656 participants11 studies pooledAnti-Inflammatory Support forSelenium
  25. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
    Randomized trial33 participantsAnti-Inflammatory Support forSelenium
  26. The effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: a randomized double-blind control trial.
    Namazi N; Esfanjani AT; Heshmati J; Bahrami A · Pakistan journal of biological sciences : PJBS · 2012
    Randomized trial50 participantsAnti-Inflammatory Support forStinging Nettle
  27. Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial.
    Akbar Karami A; Sheikhsoleimani M; Reza Memarzadeh M; Haddadi E; Bakhshpour M; Mohammadi N; Mehdi Mirhashemi S · Pakistan journal of biological sciences : PJBS · 2021
    Randomized trial60 participantsAnti-Inflammatory Support forStinging Nettle
  28. Safety, Tolerability, and Efficacy of Hox Alpha, a Dry Extract from Stinging Nettle Leaves versus OTC NSAIDs in Osteoarthritis: A Retrospective, Propensity-Matched 12-Week Analysis from the German Pain e-Registry (SIPHARO Study).
    Überall MA; Küster MA; Müller-Schwefe PCG; Müller-Schwefe GHH · Journal of pain research · 2026
    Cohort study2,146 participantsAnti-Inflammatory Support forStinging Nettle
  29. [Recommendations of the DGRh Committee on Complementary Medicine and Nutrition on the application of selected phytotherapeutic drugs and herbal medicines in rheumatology].
    Keyßer G; Seifert O; Frohne I; Michalsen A; Pfeil A; Reuß-Borst M; Sander O · Zeitschrift fur Rheumatologie · 2025
    Guideline / consensusAnti-Inflammatory Support forStinging Nettle
  30. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain
    C Randall, H Randall, F Dobbs, C Hutton, H Sanders · Journal of the Royal Society of Medicine · 2000
    Randomized trial27 participantsAnti-Inflammatory Support forStinging Nettle
  31. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  32. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  33. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  34. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  35. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  36. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
    Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
    Randomized trial40 participantsAnti-Inflammatory Support forZinc
  37. Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
    Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
    Meta-analysis23 studies pooledAnti-Inflammatory Support forZinc
  38. The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
    Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Meta-analysis73 studies pooledAnti-Inflammatory Support forZinc
  39. The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
    Randomized trial46 participantsAnti-Inflammatory Support forZinc
  40. Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
    Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Meta-analysis75 studies pooledAnti-Inflammatory Support forZinc
  41. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  42. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  43. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  44. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  45. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  46. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle
  47. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  48. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  49. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  50. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  51. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  52. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  53. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  54. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  55. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  56. Parenteral Nutrition Containing Fish Oil for Hospitalized Non-Intensive Care Unit (ICU) Patients: A Systematic Review, Meta-Analysis, and Cost-Effectiveness Analysis.
    Pradelli L; Heller AR; Klek S; Mayer K; Rosenthal MD; Muscaritoli M · Nutrients · 2025
    Meta-analysis29 studies pooledGeneral Health forFish Oil
  57. Effects of fish oil during hemodialysis on nutritional status and quality of life: a randomized double-blinded trial.
    Zhang C; Ge C; Wang J; Sun D · Food & nutrition research · 2022
    Randomized trial103 participantsGeneral Health forFish Oil
  58. The effects of fish oil plus vitamin D3 intervention on non-alcoholic fatty liver disease: a randomized controlled trial.
    Guo XF; Wang C; Yang T; Ma WJ; Zhai J; Zhao T; Xu TC; Li J; Liu H; Sinclair AJ; Li D · European journal of nutrition · 2022
    Randomized trial111 participantsGeneral Health forFish Oil
  59. Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality.
    O'Keefe EL; O'Keefe JH; Tintle NL; Westra J; Albuisson L; Harris WS · Mayo Clinic proceedings · 2024
    Meta-analysis117,702 participants17 studies pooledGeneral Health forFish Oil
  60. Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review.
    Marik PE; Varon J · Clinical cardiology · 2010
    Meta-analysis39,044 participants11 studies pooledGeneral Health forFish Oil
  61. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  62. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  63. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  64. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  65. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  66. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  67. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  68. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  69. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  70. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  71. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  72. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  73. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  74. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  75. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  76. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
    Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Saito Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Japan EPA lipid intervention study (JELIS) Investigators · Lancet (London, England) · 2007
    Randomized trial18,645 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  77. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
    Saito Y; Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; JELIS Investigators, Japan · Atherosclerosis · 2008
    Randomized trial14,981 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  78. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis.
    Dinu M; Sofi F; Lotti S; Colombini B; Mattioli AV; Catapano AL; Casula M; Baragetti A; Wong ND; Steg PG; Ambrosio G · European journal of preventive cardiology · 2024
    Meta-analysis134,144 participants18 studies pooledHeart Health forEPA (Eicosapentaenoic Acid)
  79. Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
    Matsuzaki M; Yokoyama M; Saito Y; Origasa H; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Matsuzawa Y; JELIS Investigators · Circulation journal : official journal of the Japanese Circulation Society · 2009
    Randomized trialHeart Health forEPA (Eicosapentaenoic Acid)
  80. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
    Skulas-Ray AC; Wilson PWF; Harris WS; Brinton EA; Kris-Etherton PM; Richter CK; Jacobson TA; Engler MB; Miller M; Robinson JG; Blum CB; Rodriguez-Leyva D; de Ferranti SD; Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology · Circulation · 2020
    OtherHeart Health forEPA (Eicosapentaenoic Acid)