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Magnesium Glycinate 400 mg

4.8
★ ★ ★ ★ ★
(452 ratings)
Magnesium 400 mg
Product Image
Score81
Pure high-dose bisglycinate offers strong quality and broad goal fit, but four capsules, cost, and tolerance limit practicality.
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Capsule
Quantity:60 Capsule(s) • (15 servings)
Goals:
Bone Health
General Health
Stress Relief
Cardiovascular Support
Sleep Support
Testosterone Support
Heart Health
Energy

Score 81

Pure high-dose bisglycinate offers strong quality and broad goal fit, but four capsules, cost, and tolerance limit practicality.
How scoring works

Also available as

1 option
120 servings Magnesium 400 mg • 120 Capsule(s) • 30 servings $23.96 ($0.79 per serving)
$13.56($0.90 per serving)
Pure Formulas
$ 13.56
Daily Vita
$ 13.56
iHerb
$ 13.56
Walmart
$ 16.25
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Analysis

Magnesium bisglycinate is a well-tolerated chelated form with clear single-form labeling. The substantial amount supports stress, sleep, muscle, cardiovascular, and bone pathways.

The form is generally gentler than citrate or oxide, but the large amount can still exceed some users' digestive tolerance. Splitting the serving may be more practical if the label permits.

Four capsules per serving create considerable pill burden and a costly routine. It suits users who value pure bisglycinate and high potency over convenience.

Who is it for
  • Adults seeking high-dose bisglycinate
  • People targeting stress or sleep support
Best for
  • Stress and sleep support
  • Bone and general magnesium replenishment

Pros

  • Pure bisglycinate form
  • Substantial elemental amount
  • Broad goal fit

Cons

  • Four capsules per serving
  • High serving cost
  • More than many users need for maintenance

Warnings

  • A 400 mg serving may cause diarrhea or cramping even though bisglycinate is generally gentle

Nutrient quality

88 Highest impact

A substantial bisglycinate amount gives the formula excellent absorption potential. High-dose tolerability and narrow pathway coverage are the main limitations.

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Ingredient transparency

84 Highest impact

The active form and elemental amount are specific, with no hidden blend. Intake directions and non-active ingredients were not included in the supplied details.

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Customer satisfaction

70 High impact

The available satisfaction metric and sample size provide the clearest evidence for general acceptance. Specific experience details are absent, so repeated complaints and purpose fit remain uncertain.

.

Value for money

79 High impact

Premium form quality partly supports the higher serving cost. Several capsules and a costly serving reduce competitiveness.

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Goals

Bone Health
Bone Health
Impact
Highest effect
A+ Goal FitA- Strength of SupportA CoverageA+ Formula Quality
Magnesium · 400 mg

The formula directly targets mineral structure, absorption, and remodeling with multiple bone-specific actives. Hydroxyapatite calcium, vitamin D, vitamin K, magnesium, and boron have strong complementary skeletal rationale.

The formula provides useful amounts across calcium, magnesium, vitamin D, K2, boron, and phosphorus. The formula covers mineral structure, absorption, remodeling, and trace-mineral support.

Study evidence
Magnesium Supportive 48 studies
General Health
General Health
Impact
Highest effect
A Goal FitA Strength of SupportC CoverageA Formula Quality
Magnesium · 400 mg

Magnesium bisglycinate provides highly relevant support for energy metabolism, muscle function, and nervous-system regulation. The chelated form has strong absorption potential and the 400 mg elemental amount is clearly stated.

Four capsules are needed for the full serving, which may reduce convenience. The focused formula otherwise offers deep magnesium support without unnecessary ingredients.

Study evidence
Magnesium Supportive 114 studies
Stress Relief
Stress Relief
Impact
Highest effect
B+ Goal FitA+ Strength of SupportC+ CoverageA+ Formula Quality
Magnesium · 400 mg

Magnesium bisglycinate directly supports nervous system regulation and muscle relaxation. The single mineral is well suited to foundational stress support, though it does not address adaptogenic or neurotransmitter pathways separately.

The fully disclosed amount is substantial and uses a well-absorbed form. The high amount may cause digestive upset in sensitive users, while the focused formula avoids unnecessary ingredients.

Study evidence
Magnesium Supportive 13 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A Goal FitA- Strength of SupportC CoverageA+ Formula Quality
Magnesium · 400 mg

Ubiquinone supports mitochondrial energy production in heart muscle and provides lipid-phase antioxidant activity. The standard amount may be especially relevant when statin use or low CoQ10 status is a concern.

The focused capsule clearly discloses the ubiquinone amount and form. CoQ10 may reduce warfarin’s anticoagulant effect, so stable use requires clinical monitoring.

Sleep Support
Sleep Support
Impact
Highest effect
B+ Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Magnesium · 400 mg

Magnesium bisglycinate provides a substantial, clearly disclosed mineral amount in a form well suited to nighttime relaxation. The chelated form offers good absorption and is generally less laxative than citrate.

Support remains limited to mineral-based relaxation without a circadian or separate mental-calming ingredient. The four-capsule serving may be inconvenient, but no conflicting stimulant or unnecessary active is present.

Study evidence
Magnesium Supportive 23 studies
Testosterone Support
Testosterone Support
Impact
High effect
C+ Goal FitA Strength of SupportC- CoverageA+ Formula Quality
Magnesium · 400 mg

Magnesium bisglycinate may support endocrine function and free-testosterone status when magnesium intake is low. Evidence for a meaningful hormone change in magnesium-replete users remains limited.

The 400 mg amount is clearly disclosed in a highly absorbable form. Four capsules supply the dose, and the full amount may still cause loose stools in sensitive users.

Study evidence
Magnesium Disputed 5 studies

Ingredients

IngredientAmount per serving
Magnesium (Magnesium Bisglycinate)
 400 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overview
Magnesium (Magnesium Bisglycinate) · 400 mg OverallScore74
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD+ Value

Magnesium bisglycinate offers high absorption potential, and the clearly stated 400 mg elemental serving fits the target range. The clean single-ingredient formula lacks a cofactor and does not identify a patented chelation standard. Its high serving cost weakens value despite the premium mineral form.

View ingredientView products
Loading alternative details
88 Performance

Magnesium Bisglycinate Powder

NOW
<p>Magnesium bisglycinate supplies a well-absorbed form at a practical, moderate amount. Compared with the original, its magnesium form, dose clarity, and focused design offer a stronger quality-oriented option.</p>
85 Performance

Cal/Mag 500 mg/250 mg

NaturesPlus
<p>Chelated calcium and magnesium provide a focused, balanced mineral formula with strong form quality. Compared with the original, its magnesium form, dose clarity, and focused design offer a stronger quality-oriented option.</p>
85 Performance

Magnesium Bisglycinate 200 mg

Natural Factors
<p>A focused magnesium bisglycinate powder uses a highly absorbable form at a moderate, practical amount. Compared with the original, its magnesium form, dose clarity, and focused design offer a stronger quality-oriented option.</p>
85 Budget

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate provides high-quality absorption quality, a useful elemental amount, and strong serving value in a clean powder. Its lower supplied serving cost makes it a more economical magnesium option than the original.</p>
91 Budget

Krebs Magnesium Potassium Complex

Nature's Way
<p>Magnesium lysinate and malate provide favorable forms at a useful amount, with a modest potassium contribution. Its lower supplied serving cost makes it a more economical magnesium option than the original.</p>
83 Budget

Magnesium Citrate Pure Powder

Best Naturals
<p>A well-aligned amount of magnesium citrate delivers useful absorption in a focused powder. Its lower supplied serving cost makes it a more economical magnesium option than the original.</p>
84 Value

Magnesium Glycinate

NOW
<p>Magnesium glycinate is a well-absorbed form that is often gentle on digestion. Its stated magnesium form, practical dose, and lower serving cost offer a stronger balance of quality and value than the original.</p>
83 Value

Magnesium Citrate 420 mg

Nutricost
<p>A substantial amount of magnesium citrate offers useful absorption and a focused formula. Its stated magnesium form, practical dose, and lower serving cost offer a stronger balance of quality and value than the original.</p>
83 Value

Magnesium Citrate 200 mg

Best Naturals
<p>A substantial amount of magnesium citrate combines useful absorption with a focused single-active design. Its stated magnesium form, practical dose, and lower serving cost offer a stronger balance of quality and value than the original.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  2. The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature.
    Arab A; Rafie N; Amani R; Shirani F · Biological trace element research · 2023
    Systematic review7,582 participants9 studies pooledSleep Support forMagnesium
  3. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  4. Effects of zinc and magnesium supplements on postpartum depression and anxiety: A randomized controlled clinical trial.
    Fard FE; Mirghafourvand M; Mohammad-Alizadeh Charandabi S; Farshbaf-Khalili A; Javadzadeh Y; Asgharian H · Women & health · 2017
    Randomized trial99 participantsStress Relief forMagnesium
  5. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  6. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  7. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  8. Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults.
    Joris PJ; Plat J; Bakker SJ; Mensink RP · Scientific reports · 2018
    Randomized trial52 participantsCardiovascular Support forMagnesium
  9. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  10. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  11. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  12. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  13. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  14. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  15. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  16. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  17. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  18. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  19. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  20. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  21. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  22. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  23. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  24. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledHeart Health forMagnesium
  25. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  26. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  27. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  28. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forMagnesium
  29. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  30. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  31. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  32. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  33. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  34. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  35. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  36. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  37. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  38. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  39. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  40. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  41. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium