Product Image

High Potency Vitamin B Complex

Lake Avenue Nutrition
4.5
★ ★ ★ ★ ★
(14939 ratings)
Thiamin 110 mg
Niacin 140 mg
Vitamin B5 110 mg
Riboflavin 10 mg
Vitamin B12 400 mcg
Biotin 500 mcg
Choline 28 mg
Product Image
Score83

A larger-supply activated B complex with strong forms and clear amounts. High niacin is the decisive trade-off for regular use.

How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
Energy
General Health

Score 83

A larger-supply activated B complex with strong forms and clear amounts. High niacin is the decisive trade-off for regular use.

How scoring works

Also available as

1 option
30 servings 1 Capsule(s) • 30 Capsule(s) • 30 servings $7.18 ($0.23 per serving)
$20.23($0.22 per serving)
iHerb
$ 20.23
iHerb
$ 20.23
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Analysis

The capsule combines methylfolate, methylcobalamin, riboflavin 5-phosphate, and pyridoxal 5-phosphate. Thiamine and pantothenic acid are also supplied at high amounts.

Niacin reaches 140 mg through niacinamide and nicotinic acid, while choline is limited to 28 mg. The formula is transparent, but the niacin amount may be more aggressive than many users need.

A 90-serving supply improves routine practicality compared with the smaller version. It remains best suited to users who deliberately want activated B forms and can tolerate high niacin.

Who is it for
  • Regular users seeking activated B vitamins
  • Adults wanting methylfolate and methylcobalamin
  • People who tolerate high-niacin formulas
Best for
  • Activated B-complex intake
  • Normal energy metabolism
  • Methylated folate and B12 coverage

Pros

  • Multiple activated forms
  • Includes methylfolate and methylcobalamin
  • Large serving supply
  • Clear ingredient amounts

Cons

  • Niacin amount is very high
  • Choline contribution is modest
  • Narrower than a full cognitive or hair formula

Warnings

  • The 140 mg niacin amount may cause flushing or digestive discomfort
  • People with glucose-control or liver concerns should discuss high-niacin use with a clinician
  • Avoid stacking it with other high-dose niacin products

Nutrient quality

82 Highest impact

Several active coenzyme forms and substantial amounts create strong metabolic coverage. High niacin with an unclear nicotinic-acid share makes tolerability harder to predict.

Ingredient transparency

83 Highest impact

All B vitamins have separate amounts and no proprietary blend hides the core formula. Duplicate entries make the split between niacin forms and some nutrient sources harder to interpret.

Customer satisfaction

77 High impact

The strong average rating is supported by an exceptionally large review base. No review excerpts describe tolerance, effectiveness, or repeated complaints, so those experiences remain uncertain.

Value for money

91 Highest impact

Premium active forms and a long supply provide excellent ongoing value. Potential niacin flushing is the main practical limitation in an otherwise efficient formula.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A Goal FitA Strength of SupportC+ CoverageA Formula Quality
Vitamin B5 · 110 mgRiboflavin · 10 mgThiamin · 110 mgVitamin B12 · 400 mcg

High-potency thiamin, methylcobalamin, active folate, riboflavin phosphate, and pyridoxal phosphate provide strong support for energy metabolism. The amounts are clearly disclosed in a focused one-capsule formula.

No alertness or adaptogenic pathway is included, so benefits are mainly nutritional rather than immediate. The high niacin amount may cause flushing or digestive discomfort in sensitive users.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
General Health
General Health
Impact
Highest effect
B+ Goal FitA- Strength of SupportC+ CoverageA Formula Quality
Folate · 670 mcg DFEVitamin B12 · 400 mcg

Methylfolate, methylcobalamin, active riboflavin, and other B vitamins provide focused support for cellular energy and methylation. The one-capsule design is transparent and avoids unrelated botanical padding.

Several nutrients are supplied far above ordinary daily needs, making the formula more suitable for a defined use than broad maintenance. Nicotinic acid may cause flushing, and prolonged daily vitamin B6 intake deserves caution if tingling or numbness develops.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Metabolism Boost
Metabolism Boost
Impact
Moderate effect
D Goal FitB- Strength of SupportD CoverageB Formula Quality
Biotin · 500 mcgNiacin · 140 mgVitamin B12 · 400 mcgRiboflavin · 10 mgThiamin · 110 mgVitamin B5 · 110 mgVitamin B6 · 10 mg

High-potency B vitamins support cellular energy reactions but do not directly increase metabolic rate or fat burning. Any practical benefit is most likely when a B-vitamin shortage is limiting normal energy production.

Riboflavin phosphate, P-5-P, methylfolate, and methylcobalamin give the formula strong form quality. The sizeable nicotinic acid portion may cause temporary warmth, flushing, or tingling in sensitive users.

Study evidence
Niacin Supportive 17 studies
Riboflavin Mixed 5 studies
Vitamin B12 Supportive 10 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
D Goal FitC Strength of SupportD CoverageB Formula Quality
Choline · 28 mgThiamin · 110 mgVitamin B6 · 10 mgFolate · 670 mcg DFEVitamin B12 · 400 mcg

Thiamine, active B6, methylfolate, and methylcobalamin support normal energy and neurotransmitter metabolism when nutrient status is low. The 28 mg choline amount is too small and uses a standard systemic form rather than a brain-targeted option.

Several B-vitamin forms are strong and clearly disclosed in one capsule. The focused B-complex is well organized, but it does not provide a direct cognitive active or broad pathway coverage.

Study evidence
Choline Supportive 76 studies
Thiamin Supportive 30 studies
Vitamin B12 Disputed 84 studies
Hair Health
Hair Health
Impact
Moderate effect
D- Goal FitC Strength of SupportD- CoverageC- Formula Quality
Biotin · 500 mcg

Biotin and methylcobalamin may support hair when B-vitamin intake is inadequate. The formula does not address iron, zinc, structural proteins, or androgen pathways.

Clear forms and amounts are strengths, while the biotin amount is modest. The B-complex is nutritionally coherent but narrow for hair health.

Study evidence
Biotin Supportive 4 studies
Vitamin B12 Disputed 17 studies

Ingredients

IngredientAmount per serving
Thiamine Hydrochloride
110 mg
Riboflavin (Riboflavin 5-Phosphate)
 10 mg
Niacin (Niacinamide, Nicotinic Acid)
 140 mg
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
 10 mg
Folate ((6S)-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
 670 mcg DFE
Vitamin B12 (Methylcobalamin)
 400 mcg
Biotin
500 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 110 mg
Choline (Choline Dihydrogen Citrate)
 28 mg
Inositol
100 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Thiamin · 110 mg OverallScore88
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Thiamine hydrochloride provides a clearly disclosed standard form at a strong high-potency amount. The swallowed veggie capsule uses ordinary delivery rather than a premium absorption system. A below-median serving cost and substantial B1 amount make this B-complex cost-efficient under the collection rule.

View ingredientView products
Niacin (Niacinamide, Nicotinic Acid) · 140 mg OverallScore71
B+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyC Value

A blend of niacinamide and nicotinic acid gives broad B-complex coverage with fully named forms. Standard capsule delivery is straightforward but offers no release control. The sizeable nicotinic acid portion may cause temporary warmth, redness, or tingling, yet no flush warning appears in the supplied label data.

View ingredientView products
Vitamin B5 (D-Calcium Pantothenate) · 110 mg OverallScore66
B Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

D-calcium pantothenate provides a stable, well-absorbed form of vitamin B5. The 110 mg serving provides general maintenance and metabolic support, and the source is clearly named. Value is limited because reaching a high-potency amount would require multiple servings, and excipient details were not supplied.

View ingredientView products
Loading alternative details
85 Performance

B-Complex Plus

Pure Encapsulations
<p>Methylfolate, methylcobalamin, P-5-P, and activated riboflavin retain active forms while using a more restrained vitamin B6 amount. Elevated niacin still deserves attention, but the formula is better balanced than the original high-potency blend.</p>
85 Performance

BioCoenzymated Active B Complex

Natural Factors
<p>Active thiamine, riboflavin, vitamin B6, folate, and vitamin B12 provide broad refined coverage. Moderate vitamin B6 and clearer niacin positioning improve routine-use balance compared with the original.</p>
81 Performance

CellularActive Coenzyme B-Complex

Bluebonnet
<p>Several coenzyme B-vitamin forms create broad energy and metabolism coverage with moderate vitamin B6. Mixed folate forms and small choline are limitations, but the overall dosing is less aggressive than the original.</p>
84 Budget

Super B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
<p>A broad B-complex provides B12, niacin, thiamine, biotin, and riboflavin at a lower serving cost with less aggressive dosing. Forms are more basic and high biotin can affect laboratory tests, but everyday use may be easier to justify.</p>
80 Budget

B-Complex '100'

Solgar
<p>Broad B12, niacin, thiamine, vitamin B6, riboflavin, choline, and pantothenic acid coverage comes at a lower serving cost. Conventional forms and very high vitamin B6 make it less refined than the original active-form formula.</p>
75 Budget

B-100

NOW
<p>High-potency B vitamins provide inexpensive collection overlap at a lower serving cost. The supplied panel unexpectedly omits vitamin B6 and uses conventional forms, so the savings come with weaker completeness and quality.</p>
80 Value

B-Complex '100'

Solgar
<p>Broad B-vitamin coverage reaches the original product’s main collections at a much lower serving cost. Conventional forms and very high vitamin B6 limit long-term suitability, but the value is strong for targeted high-potency use.</p>
80 Value

B-100 Complex with B2 Coenzyme

Nature's Way
<p>Active riboflavin and partial P-5-P improve a broad B-complex at a lower serving cost. Total vitamin B6 remains very high, but the formula offers substantial coverage without the original niacin-form ambiguity.</p>
72 Value

Complete B 100 mg

Natural Factors
<p>A broad B-100 formula provides extensive collection coverage at a lower serving cost. Conventional forms and excessive vitamin B6 reduce refinement, but the formula remains economical when high potency is intentionally sought.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis.
    Long C; Li Z; Feng H; Jiang Y; Pu Y; Tao J; Yue R · Frontiers in aging neuroscience · 2024
    Meta-analysis82,246 participants9 studies pooledCognitive Support forCholine
  2. Gut microbiota-mediated choline metabolism exacerbates cognitive impairment induced by chronic cerebral hypoperfusion.
    Li X; Ren Y; Gao X; Wang H; Zhang J; Xie J; Liang J; Zhao B; Zhou H; Yin J · Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Cross-sectional studyCognitive Support forCholine
  3. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
    Cohort study125,594 participantsCognitive Support forCholine
  4. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
    Randomized trial36 participantsCognitive Support forCholine
  5. Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study.
    Yamashita S; Kawada N; Wang W; Susaki K; Takeda Y; Kimura M; Iwama Y; Miura Y; Sugano M; Matsuoka R · Lipids in health and disease · 2023
    Randomized trial41 participantsCognitive Support forCholine
  6. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  7. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  8. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M · Clinical therapeutics · 2003
    Randomized trial261 participantsCognitive Support forCholine
  9. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
    Cohort study895 participantsCognitive Support forCholine
  10. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  11. Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life.
    Measelle JR; Baldwin DA; Gallant J; Chan K; Green TJ; Wieringa FT; Borath M; Prak S; Hampel D; Shahab-Ferdows S; Allen LH; Kroeun H; Whitfield KC · Annals of the New York Academy of Sciences · 2021
    Randomized trial335 participantsCognitive Support forThiamin
  12. What is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? - A systematic review.
    Teixeira J; Pereira I; Castanho M; Simões do Couto F · European journal of internal medicine · 2025
    Systematic reviewCognitive Support forThiamin
  13. Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.
    Jia W; Wang H; Li C; Shi J; Yong F; Jia H · Journal of translational medicine · 2024
    Cross-sectional study2,422 participantsCognitive Support forThiamin
  14. Association of vitamin B1 intake with geriatric cognitive function: An analysis of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014.
    Ji K; Sun M; Hong Y; Li L; Wang X; Li C; Yang S; Du W; Xu K; Zhou H · Heliyon · 2024
    Cross-sectional study2,896 participantsCognitive Support forThiamin
  15. A systematic review of treatments for alcohol-related cognitive impairment: lessons from the past and gaps for future interventions.
    Caballeria E; Oliveras C; Nuño L; Balcells-Oliveró M; Gual A; López-Pelayo H · Psychological medicine · 2021
    Systematic review26 studies pooledCognitive Support forThiamin
  16. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
    Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS · Frontiers in endocrinology · 2021
    Systematic review46 studies pooledCognitive Support forVitamin B12
  17. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
    Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K · Maternal and child health journal · 2019
    Randomized trial218 participantsCognitive Support forVitamin B12
  18. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsCognitive Support forVitamin B12
  19. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsCognitive Support forVitamin B12
  20. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsCognitive Support forVitamin B12
  21. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  22. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  23. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  24. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  25. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  26. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  27. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  28. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  29. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  30. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  31. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  32. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  33. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  34. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  35. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  36. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  37. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  38. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  39. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  40. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  41. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  42. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  43. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  44. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  45. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  46. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  47. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  48. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  49. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  50. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forVitamin B12
  51. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  52. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  53. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  54. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  55. Niacin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Boost forNiacin
  56. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans.
    Fangmann D; Theismann EM; Türk K; Schulte DM; Relling I; Hartmann K; Keppler JK; Knipp JR; Rehman A; Heinsen FA; Franke A; Lenk L; Freitag-Wolf S; Appel E; Gorb S; Brenner C; Seegert D; Waetzig GH; Rosenstiel P; Schreiber S; Schwarz K; Laudes M · Diabetes care · 2018
    Clinical trialMetabolism Boost forNiacin
  57. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.
    Christen S; Redeuil K; Goulet L; Giner MP; Breton I; Rota R; Frézal A; Nazari A; Van den Abbeele P; Godin JP; Nutten S; Cuenoud B · Nature metabolism · 2026
    Randomized trial65 participantsMetabolism Boost forNiacin
  58. Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance.
    Linke A; Sonnabend M; Fasshauer M; Höllriegel R; Schuler G; Niebauer J; Stumvoll M; Blüher M · Atherosclerosis · 2009
    Randomized trial30 participantsMetabolism Boost forNiacin
  59. Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.
    Vaag A; Skött P; Damsbo P; Gall MA; Richter EA; Beck-Nielsen H · The Journal of clinical investigation · 1991
    Clinical trial12 participantsMetabolism Boost forNiacin
  60. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  61. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
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    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
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    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
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    Saravanan P; Sukumar N; Adaikalakoteswari A; Goljan I; Venkataraman H; Gopinath A; Bagias C; Yajnik CS; Stallard N; Ghebremichael-Weldeselassie Y; Fall CHD · Diabetologia · 2022
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    Carmel R; Melnyk S; James SJ · Blood · 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  67. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D · Frontiers in pharmacology · 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
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    Kanvinde P; Khurana R; Mudaliar S · Frontiers in nutrition · 2026
    Narrative reviewMetabolism Boost forVitamin B12