Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
Randomized trial40 participantsflagSleep Support forscienceGABA
- Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
Case-control study40 participantsflagSleep Support forscienceGABA
- Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
Randomized trial54 participantsflagStress Relief forscienceValerian
- Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
Randomized trial20 participantsflagStress Relief forscienceValerian
- Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
Randomized trial63 participantsflagStress Relief forscienceGABA
- GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
Randomized trial30 participantsflagStress Relief flagSleep Support forscienceGABA
- Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
Randomized trial160 participantsflagSleep Support forscienceGABA
- Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
Randomized trial320 participantsflagSleep Support forscienceMagnesium
- Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
Cohort study3,964 participantsflagSleep Support forscienceMagnesium
- Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
Randomized trial120 participantsflagSleep Support forscienceMagnesium
- The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
Randomized trial46 participantsflagSleep Support forscienceMagnesium
- A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
Randomized trial175 participantsflagSleep Support forscienceMagnesium
- Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
Randomized trial80 participantsflagSleep Support flagStress Relief forscienceValerian
- Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
Randomized trial40 participantsflagSleep Support forscienceValerian
- Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
Randomized trial202 participantsflagSleep Support forscienceValerian
- Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
Randomized trial40 participantsflagSleep Support forscienceValerian
- Valerian for sleep: a systematic review and meta-analysis.
Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
Meta-analysis1,093 participants16 studies pooledflagSleep Support forscienceValerian
- Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
Clinical trial30 participantsflagStress Relief forscienceGABA
- Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
Case-control study45 participantsflagStress Relief forscienceGABA
- Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
Randomized trial168 participantsflagStress Relief forscienceGABA
- Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
Randomized trial126 participantsflagStress Relief forscienceMagnesium
- Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
Randomized trial137 participantsflagStress Relief forscienceMagnesium
- Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
Non-randomized trial60 participantsflagStress Relief forscienceMagnesium
- Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
Randomized trial45 participantsflagStress Relief forscienceMagnesium
- Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
Randomized trialflagStress Relief forscienceMagnesium
- Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
Systematic review327 participants12 studies pooledflagStress Relief forscienceValerian
- Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
Non-randomized trial54 participantsflagStress Relief forscienceValerian
- Stress-induced insomnia treated with kava and valerian: singly and in combination.
Wheatley D · Human psychopharmacology · 2019
Single-arm trial24 participantsflagStress Relief forscienceValerian