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GABA Relaxer

Country Life
4.7
★ ★ ★ ★ ★
(797 ratings)
GABA 200 mg
Vitamin B6 17 mg
Niacin 200 mg
Glycine 400 mg
Taurine 600 mg
Product Image
Score68
A transparent calming blend provides several complementary amino acids, but the key amounts are modest. Elevated niacinamide and B6 are the main drawbacks for routine use.
How scoring works
Quantity:90 Tablet(s) • (45 servings)
Goals:
Sleep Support
Mood Support
Stress Relief
Detoxification

Score 68

A transparent calming blend provides several complementary amino acids, but the key amounts are modest. Elevated niacinamide and B6 are the main drawbacks for routine use.
How scoring works
$22.99($0.51 per serving)
iHerb
$ 22.99
Pure Formulas
$ 22.99
Vitacost
$ 22.99
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Analysis

GABA, taurine, inositol, and glycine cover several calming pathways without relying on a large stimulant or botanical blend. The exact amounts are visible, although the 200 mg GABA and 400 mg glycine servings are modest for targeted use.

Niacinamide and vitamin B6 add nutritional support but are unusually prominent in a relaxation formula. A 200 mg niacinamide serving and 17 mg pyridoxine create more long-term exposure than many users need.

The tablets may fit occasional evening use for someone who wants a broad amino-acid blend. People seeking a more focused sleep product or lower-dose daily formula may find the ingredient balance less convincing.

Who is it for
  • Adults seeking occasional calming support
  • People who prefer a non-caffeine formula
  • Users comfortable with a multi-ingredient tablet
Best for
  • Evening relaxation
  • Stress-support routines
  • Broad amino-acid coverage

Pros

  • Fully disclosed active amounts
  • Combines four calming amino-acid compounds
  • No caffeine listed
  • Multiple servings per container

Cons

  • GABA amount is fairly modest
  • Glycine amount is low for focused use
  • High niacinamide is not central to relaxation
  • Pyridoxine is a conventional B6 form

Warnings

  • The 17 mg vitamin B6 amount may add unnecessary long-term exposure when combined with other B6 supplements.
  • GABA and glycine may cause drowsiness, so assess tolerance before driving or combining with sedating products.
  • The 200 mg niacinamide amount may cause nausea or stomach discomfort in sensitive users.

Nutrient quality

62 Moderate impact

Taurine, inositol, glycine, and GABA fit a relaxation formula, though several amounts are modest. High niacinamide and vitamin B6 weaken the balance for routine use.

Ingredient transparency

78 High impact

Active amounts are fully disclosed without a hidden blend. Usage directions and inactive ingredients are missing from the supplied label data.

Customer satisfaction

72 High impact

The rating and large review base provide a strong top-level signal. Missing review details leave recurring complaints and relaxation experiences unverified.

Value for money

59 Moderate impact

The focused blend provides fair value without obvious decorative extras. Modest amino-acid amounts limit the value of each serving.

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Goals

Sleep Support
Sleep Support
Impact
High effect
B- Goal FitB Strength of SupportB CoverageB- Formula Quality
Glycine · 400 mg

GABA, taurine, inositol, and glycine create a broad relaxation formula that may help when nervous tension delays sleep. Several amounts are useful within a blend, although glycine and GABA remain below stronger standalone sleep doses and oral GABA evidence is limited.

Every active amount is stated, but the tablet uses pyridoxine rather than the preferred active vitamin B6 form. The large niacinamide amount adds little direct sleep value and may cause stomach upset in sensitive users.

Study evidence
GABA Supportive 4 studies
Glycine Supportive 3 studies
Taurine Not classified

No linked studies yet.

Vitamin B6 Disputed 7 studies
Mood Support
Mood Support
Impact
High effect
C+ Goal FitB- Strength of SupportB CoverageB+ Formula Quality
Vitamin B6 · 17 mg

GABA, taurine, inositol, glycine, and vitamin B6 create broad calming and neurotransmitter support. Evidence for oral GABA and these moderate-dose combinations is limited, but the formula is clearly aligned with tension and relaxation.

All amounts are disclosed, though the pressed-tablet format and generic GABA offer no delivery advantage. The blend may cause relaxation or drowsiness in some users, so its effect should be known before driving.

Study evidence
GABA Supportive 12 studies
Glycine Mixed 3 studies
Vitamin B6 Supportive 19 studies
Stress Relief
Stress Relief
Impact
High effect
B- Goal FitC+ Strength of SupportC+ CoverageB Formula Quality
Glycine · 400 mgGABA · 200 mgVitamin B6 · 17 mg

GABA, taurine, glycine, and inositol create a coherent calming blend that targets inhibitory signaling and physical relaxation. All active amounts are disclosed, which makes the formula easier to judge than a proprietary blend.

The 200 mg GABA and 600 mg taurine are plausible supporting amounts, but glycine and inositol are well below common standalone use levels. The blend may cause drowsiness, so users should learn its effect before driving or combining it with alcohol or sedative medicines.

Study evidence
GABA Supportive 6 studies
Glycine Supportive 1 study
Taurine Supportive 5 studies
Detoxification
Detoxification
Impact
High effect
B- Goal FitC Strength of SupportC+ CoverageC+ Formula Quality
Vitamin B6 · 17 mgTaurine · 600 mgGlycine · 400 mg

Taurine and glycine support bile and Phase II conjugation, while B6 provides a metabolic cofactor. Inositol adds liver-metabolism context, but GABA is aimed more at calming than detoxification.

Taurine and glycine are clearly disclosed but sit below strong standalone amounts. Niacinamide and pyridoxine are basic forms, and the formula lacks a liver-protective botanical or antioxidant-recycling core.

Study evidence
Glycine Supportive 5 studies
Taurine Supportive 2 studies
Anti-Aging
Anti-Aging
Impact
Moderate effect
D Goal FitC Strength of SupportD+ CoverageB- Formula Quality
Glycine · 400 mgTaurine · 600 mg

The calming blend may support sleep and stress management, which are indirectly relevant to healthy aging. It does not directly target major longevity pathways, and several amounts fall below common stand-alone use.

Taurine, inositol, glycine, and GABA are all disclosed, but glycine is well below a typical sleep-support amount. The 200 mg niacinamide serving is substantial and may cause digestive discomfort in sensitive users.

Study evidence
Glycine Mixed 14 studies
Taurine Supportive 3 studies
General Health
General Health
Impact
Moderate effect
D+ Goal FitC- Strength of SupportD+ CoverageB- Formula Quality
Glycine · 400 mgTaurine · 600 mg

The formula is better suited to relaxation than broad daily health support. Taurine, glycine, inositol, and GABA offer a coherent calming focus, but several amounts are modest and oral GABA evidence is limited.

Clearly listed amounts improve transparency, while source and quality details are missing. The niacinamide and vitamin B6 amounts are relatively high for routine long-term use and may raise tolerance concerns.

Study evidence
Glycine Supportive 4 studies
Taurine No effect 3 studies

Ingredients

IngredientAmount per serving
Niacin (Niacinamide)
 200 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 17 mg
Taurine
600 mg
Inositol
600 mg
Glycine
400 mg
GABA
200 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
GABA · 200 mg OverallScore70
C+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD- Value

The blend clearly provides 200 mg of standard GABA alongside taurine, inositol, glycine, niacin, and vitamin B6. That GABA amount is reasonable for a complex formula, although hard-pressed tablets may disintegrate more slowly than capsules or powders. The serving cost is high for an unbranded source.

View ingredientView products
Vitamin B6 (Pyridoxine Hydrochloride) · 17 mg OverallScore62
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Synthetic pyridoxine is less direct than active P-5-P. The B6 dose is well aligned with targeted metabolic and neurological support. No listed additives create a clear purity concern.

View ingredientView products
Niacin (Niacinamide) · 200 mg OverallScore61
D+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyF Value

Niacinamide is clearly identified at an effective general-use amount, but it is not specifically matched to the relaxation focus. The tablet has no stated release technology or no-flush positioning. Its serving cost is high when assessed mainly as a niacin source.

View ingredientView products
Loading alternative details
82 Performance

Theanine Serene

Source Naturals Serene Science
<p>A more complete relaxation blend provides substantially more GABA, taurine, magnesium, and L-theanine than the original. Clear doses and the absence of very high niacinamide make it better aligned with sleep and stress support.</p>
71 Performance

NeuroCalm

Designs for Health
<p>Active B-vitamin forms, glycinate magnesium, L-theanine, taurine, chamomile, and branded GABA create a more refined calming formula. The 5-HTP content needs caution with serotonergic medicines, and the serving value is weaker.</p>
72 Performance

Anxiety Control Plus

Metabolic Maintenance
<p>Magnesium bisglycinate, more GABA, lemon balm, and passionflower give this formula a stronger calming focus than the original’s high-dose niacinamide base. Several supporting ingredients are modest, and the zero-milligram vitamin B6 listing is unclear.</p>
77 Budget

True Calm

NOW
<p>A broader calming blend offers the same GABA amount while adding magnesium bisglycinate, inositol, and valerian at better value. Niacinamide and vitamin B6 are also much less concentrated than in the original, although most supporting amino acids remain modest.</p>
76 Budget

GABA Calm Orange Flavor

Source Naturals Serene Science
<p>A low-cost lozenge keeps GABA, glycine, and taurine while avoiding the original’s high niacinamide and vitamin B6 amounts. Its supporting doses are smaller, so it fits mild situational use better than a full amino-acid supplement.</p>
74 Budget

Totally Zen

Carlson
<p>L-theanine adds a useful calming pathway alongside the same GABA amount, and the long supply improves value. Vitamin B6 remains relatively high and the magnesium blend includes oxide, but the formula is more rounded than the original.</p>
81 Value

Double Strength 5-HTP 200 mg

NOW
<p>A clearly disclosed 5-HTP dose gives this option a more direct sleep and mood focus while retaining glycine, taurine, inositol, and modest B vitamins. Value is favorable, but 5-HTP should not be combined casually with serotonergic medicines.</p>
78 Value

GABAplex

Swanson
<p>GABA, glycine, taurine, L-theanine, and tyrosine provide broader calming amino-acid coverage without the original’s large niacinamide amount. The serving economics are favorable, though black pepper extract may affect medicine absorption.</p>
77 Value

NightRest with Melatonin

Source Naturals
<p>Higher amounts of GABA, magnesium, taurine, and glycine plus calming herbs provide stronger sleep-oriented coverage than the original. The formula is cost-effective, but its melatonin amount may cause next-day drowsiness or vivid dreams in sensitive users.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Oral taurine improves critical power and severe-intensity exercise tolerance.
    Waldron M; Patterson SD; Jeffries O · Amino acids · 2020
    Randomized trial12 participantsFitness forTaurine
  2. Acute Effects of Taurine Supplementation on Maximal Fat Oxidation and FATmax in Recreational Endurance Runners: A Randomized, Placebo-Controlled, Crossover, and Triple-Blinded Study.
    Ghazzagh A; Naderi A; Agha-Alinejad H; Livani A; Sarlak M; Aghamohammadi S; Saunders B · International journal of sport nutrition and exercise metabolism · 2024
    Randomized trial11 participantsFitness forTaurine
  3. Combined but Not Isolated Ingestion of Caffeine and Taurine Improves Wingate Sprint Performance in Female Team-Sport Athletes Habituated to Caffeine.
    Karayigit R; Naderi A; Saunders B; Forbes SC; Coso JD; Berjisian E; Yildirim UC; Suzuki K · Sports (Basel, Switzerland) · 2021
    Randomized trial17 participantsFitness forTaurine
  4. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
    Bannai M; Kawai N; Ono K; Nakahara K; Murakami N · Frontiers in neurology · 2012
    Clinical trial7 participantsSleep Support forGlycine
  5. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
    Bannai M; Kawai N · Journal of pharmacological sciences · 2012
    Narrative reviewSleep Support forGlycine
  6. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.
    Field DT; Cracknell RO; Eastwood JR; Scarfe P; Williams CM; Zheng Y; Tavassoli T · Human psychopharmacology · 2022
    Randomized trial478 participantsStress Relief forVitamin B6
  7. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  8. B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study.
    Moore K; Hughes CF; Hoey L; Ward M; Cunningham C; Molloy AM; Strain JJ; McCarroll K; Casey MC; Tracey F; Laird E; O'Kane M; McNulty H · Journal of the American Medical Directors Association · 2020
    Cross-sectional study5,186 participantsStress Relief forVitamin B6
  9. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsStress Relief Sleep Support forGABA
  10. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  11. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.
    Díaz-Flores M; Cruz M; Duran-Reyes G; Munguia-Miranda C; Loza-Rodríguez H; Pulido-Casas E; Torres-Ramírez N; Gaja-Rodriguez O; Kumate J; Baiza-Gutman LA; Hernández-Saavedra D · Canadian journal of physiology and pharmacology · 2014
    Randomized trial60 participantsStress Relief General Health forGlycine
  12. Correlations between dietary taurine intake and life stress in Korean college students.
    Sung MJ; Chang KJ · Advances in experimental medicine and biology · 2009
    Observational studyStress Relief forTaurine
  13. Profiling inflammatory and oxidative stress biomarkers following taurine supplementation: a systematic review and dose-response meta-analysis of controlled trials.
    Faghfouri AH; Seyyed Shoura SM; Fathollahi P; Shadbad MA; Papi S; Ostadrahimi A; Faghfuri E · European journal of clinical nutrition · 2022
    Meta-analysisStress Relief forTaurine
  14. Accelerated biological aging, mediating amino acids, and risk of incident type 2 diabetes: a prospective cohort study.
    Zhang Z; Wang J; Yu B; Sun Y; Chen Y; Lu Y; Wang N; Xia F · Journal of endocrinological investigation · 2025
    Cohort study95,773 participantsAnti-Aging forGlycine
  15. Dietary protein and amino acid intakes for mitigating sarcopenia in humans.
    He W; Connolly ED; Cross HR; Wu G · Critical reviews in food science and nutrition · 2025
    Narrative reviewAnti-Aging forGlycine
  16. Age-Related Neurochemical Changes in the Vestibular Nuclei.
    Smith PF · Frontiers in neurology · 2016
    Narrative reviewAnti-Aging forGlycine
  17. SHMT2 regulates CD8+ T cell senescence via the reactive oxygen species axis in HIV-1 infected patients on antiretroviral therapy.
    Zhang QS; Wang JN; Yang TL; Li SY; Li JQ; Liu DN; Shang H; Zhang ZN · EBioMedicine · 2025
    Observational studyAnti-Aging forGlycine
  18. Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study.
    Cui M; Jiang Y; Zhao Q; Zhu Z; Liang X; Zhang K; Wu W; Dong Q; An Y; Tang H; Ding D; Chen X · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort studyAnti-Aging forGlycine
  19. Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women.
    Chupel MU; Minuzzi LG; Furtado GE; Santos ML; Ferreira JP; Filaire E; Teixeira AM · Amino acids · 2021
    Randomized trial48 participantsAnti-Aging forTaurine
  20. Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70.
    Abud GF; De Carvalho FG; Batitucci G; Travieso SG; Bueno Junior CR; Barbosa Junior F; Marchini JS; de Freitas EC · Nutrition (Burbank, Los Angeles County, Calif.) · 2022
    Randomized trial24 participantsAnti-Aging forTaurine
  21. Association of taurine intake with changes in physical fitness among community-dwelling middle-aged and older Japanese adults: an 8-year longitudinal study.
    Domoto T; Kise K; Oyama Y; Furuya K; Kato Y; Nishita Y; Kozakai R; Otsuka R · Frontiers in nutrition · 2024
    Cohort studyAnti-Aging forTaurine
  22. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.
    Cruz M; Maldonado-Bernal C; Mondragón-Gonzalez R; Sanchez-Barrera R; Wacher NH; Carvajal-Sandoval G; Kumate J · Journal of endocrinological investigation · 2009
    Randomized trial74 participantsAnti-Inflammatory Support forGlycine
  23. Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.
    Vargas MH; Del-Razo-Rodríguez R; López-García A; Lezana-Fernández JL; Chávez J; Furuya MEY; Marín-Santana JC · BMC pulmonary medicine · 2018
    Randomized trial13 participantsAnti-Inflammatory Support forGlycine
  24. Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing.
    Guo X; Bai H; Lu X; Guo J; Qi Y; Huo X; Li S · Clinical oral investigations · 2026
    Randomized trial80 participantsAnti-Inflammatory Support forGlycine
  25. Long-term Implant Maintenance: A Systematic Review of Home and Professional Care Strategies in Supportive Implant Therapy.
    Araújo TG; Moreira CS; Neme RA; Luan H; Bertolini M · Brazilian dental journal · 2024
    Systematic review13 studies pooledAnti-Inflammatory Support forGlycine
  26. Analysis of the factors influencing the occurrence of peri-implantitis in patients with implant-supported restoration and study on the maintenance effect of subgingival sandblasting.
    Pan T; Meng W; Zhang M; Xie Y; Chen Z; Zhou M; Yin L; Xie H · BMC oral health · 2026
    Randomized trial198 participantsAnti-Inflammatory Support forGlycine
  27. Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study.
    Rosa FT; Freitas EC; Deminice R; Jordão AA; Marchini JS · European journal of nutrition · 2015
    Randomized trial24 participantsAnti-Inflammatory Support forTaurine
  28. Effect of taurine supplementation on preventing ventilator-associated pneumonia in pediatrics under mechanical ventilation, a randomized controlled double-blind clinical trial.
    Shirzad-Yazdi N; Shorafa E; Abootalebi SN; Heidari R; Hojabri K; Doostfatemeh M; Masjedi F; Vazin A; Shafiekhani M · Frontiers in pediatrics · 2025
    Randomized trial77 participantsAnti-Inflammatory Support forTaurine
  29. Effect of taurine in muscle damage markers and inflammatory cytokines in running exercise.
    Wang Y; Xu T; Zhao H; Gu C; Li Z · Frontiers in physiology · 2022
    Non-randomized trial10 participantsAnti-Inflammatory Support forTaurine
  30. Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women.
    Chupel MU; Minuzzi LG; Furtado G; Santos ML; Hogervorst E; Filaire E; Teixeira AM · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2018
    Randomized trial48 participantsAnti-Inflammatory Support forTaurine
  31. Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure.
    Ahmadian M; Roshan VD; Aslani E; Stannard SR · Therapeutic advances in cardiovascular disease · 2017
    Randomized trialAnti-Inflammatory Support forTaurine
  32. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  33. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  34. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  35. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group.
    Guyton JR; Blazing MA; Hagar J; Kashyap ML; Knopp RH; McKenney JM; Nash DT; Nash SD · Archives of internal medicine · 2000
    Randomized trial173 participantsCardiovascular Support forNiacin
  36. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia.
    Knopp RH; Alagona P; Davidson M; Goldberg AC; Kafonek SD; Kashyap M; Sprecher D; Superko HR; Jenkins S; Marcovina S · Metabolism: clinical and experimental · 1998
    Randomized trial223 participantsCardiovascular Support forNiacin
  37. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study.
    Sun Q; Wang B; Li Y; Sun F; Li P; Xia W; Zhou X; Li Q; Wang X; Chen J; Zeng X; Zhao Z; He H; Liu D; Zhu Z · Hypertension (Dallas, Tex. : 1979) · 2016
    Randomized trial120 participantsCardiovascular Support forTaurine
  38. Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial.
    Li Y; Wang Q; Liu Y; Li Q; Xia W; Lin S; Yang Q; Scholze A; Zhao Z; He H; Zhang H; Yan Z; Tepel M; Mu H; Zhu Z; Liu D · iScience · 2025
    Randomized trial165 participantsCardiovascular Support forTaurine
  39. Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
    Tzang CC; Chi LY; Lin LH; Lin TY; Chang KV; Wu WT; Özçakar L · Nutrition & diabetes · 2024
    Meta-analysis1,024 participants25 studies pooledCardiovascular Support forTaurine
  40. Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials.
    Nie Z; Liu Y; Zhang M; Wu C; Cao Q; Xu J; Zheng Y; Min Z; Zhang W; Han S · Nutrition reviews · 2025
    Meta-analysis34 studies pooledCardiovascular Support General Health forTaurine
  41. The effects of taurine supplementation on glycemic control and serum lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
    Maleki V; Alizadeh M; Esmaeili F; Mahdavi R · Amino acids · 2021
    Randomized trial45 participantsCardiovascular Support forTaurine
  42. The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
    Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
    Cohort study42 participantsDetoxification forGlycine
  43. Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
    Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
    Single-arm trial19 participantsDetoxification forGlycine
  44. Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
    Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
    Non-randomized trial21 participantsDetoxification forGlycine
  45. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
    Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
    Methods validation study74 participantsDetoxification forGlycine
  46. The treatment of isovaleric acidemia with glycine supplement
    M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
    Non-randomized trial2 participantsDetoxification forGlycine
  47. Dietary amino acid taurine ameliorates liver injury in chronic hepatitis patients.
    Hu YH; Lin CL; Huang YW; Liu PE; Hwang DF · Amino acids · 2008
    Non-randomized trial24 participantsDetoxification forTaurine
  48. Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study.
    Schneider SM; Joly F; Gehrardt MF; Badran AM; Myara A; Thuillier F; Coudray-Lucas C; Cynober L; Trivin F; Messing B · The British journal of nutrition · 2006
    Single-arm trial32 participantsDetoxification forTaurine
  49. Taurine supplementation enhances anaerobic power in elite speed skaters: A double-blind, randomized, placebo-controlled, crossover study.
    Buzdağlı Y; Eyipınar CD; Öget F; Şıktar E; Forbes SC; Tekin A · Biology of sport · 2023
    Randomized trial30 participantsFitness forTaurine
  50. The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners.
    Balshaw TG; Bampouras TM; Barry TJ; Sparks SA · Amino acids · 2013
    Randomized trial8 participantsFitness forTaurine
  51. Effects of different doses of taurine supplementation on repeated-sprint performance after exhaustive exercise in a high temperature and humidity environment.
    Cheng X; Lin Y; Li Z · Frontiers in nutrition · 2026
    Randomized trial16 participantsFitness forTaurine
  52. Acute taurine supplementation enhances thermoregulation and endurance cycling performance in the heat.
    Page LK; Jeffries O; Waldron M · European journal of sport science · 2019
    Randomized trial11 participantsFitness forTaurine
  53. Air-abrasive debridement with glycine powder versus manual debridement and chlorhexidine administration for the maintenance of peri-implant health status: a six-month randomized clinical trial.
    Lupi SM; Granati M; Butera A; Collesano V; Rodriguez Y Baena R · International journal of dental hygiene · 2018
    Randomized trial46 participantsGeneral Health forGlycine
  54. The effects of glycine on auditory mismatch negativity in schizophrenia.
    Greenwood LM; Leung S; Michie PT; Green A; Nathan PJ; Fitzgerald P; Johnston P; Solowij N; Kulkarni J; Croft RJ · Schizophrenia research · 2018
    Randomized trial22 participantsGeneral Health forGlycine
  55. Dietary glycine improves urine storage symptoms in urology outpatients.
    Sugaya K; Oh-Oka H; Yamada T; Miyata M; Ashitomi K; Kadekawa K; Nishijima S · Journal of complementary & integrative medicine · 2021
    Non-randomized trial20 participantsGeneral Health forGlycine
  56. Cognitive Effects of Taurine and Related Sulphur-Containing Amino Acids: A Systematic Review of Human Trials and Considerations for Plant-Based Dietary Transitions.
    Moore JA; Cousins AL; Taylor RMJ; Griffiths AR; Young HA · Foods (Basel, Switzerland) · 2026
    Systematic review244 participants8 studies pooledGeneral Health forTaurine
  57. Association between habitual dietary taurine intake and the risk of metabolic dysfunction-associated steatotic liver disease: a prospective cohort study.
    Zhang S; Xu X; Wang D; Gu Y; Wu H; Meng G; Zhang Q; Liu L; Borné Y; Niu K; Bai L · Food & function · 2026
    Cohort study16,699 participantsGeneral Health forTaurine
  58. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  59. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  60. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
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  61. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  62. [Augmentation of antipsychotics with glycine may ameliorate depressive and extrapyramidal symptoms in schizophrenic patients--a preliminary 10-week open-label study].
    Strzelecki D; Kropiwnicki P; Rabe-Jabłońska J · Psychiatria polska · 2014
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  63. Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
    Pålsson E; Jakobsson J; Södersten K; Fujita Y; Sellgren C; Ekman CJ; Ågren H; Hashimoto K; Landén M · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015
    Cross-sectional study327 participantsMood Support forGlycine
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    Peselow ED; Deutsch SI; Stanley M; Banay-Schwartz M; Virgilio J; Fieve RR · Psychopharmacology · 1983
    Cross-sectional study27 participantsMood Support forGlycine
  65. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  66. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support forVitamin B6
  67. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
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    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  69. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
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  70. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
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  71. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
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  72. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
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    Soh J; Raventhiran S; Lee JH; Lim ZX; Goh J; Kennedy BK; Maier AB · GeroScience · 2024
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  74. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
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  75. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
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  76. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  77. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
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  78. The effect of pyridoxine administration on melatonin secretion in normal men.
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  79. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
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  80. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
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  81. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
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  82. Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial.
    Moludi J; Qaisar SA; Kadhim MM; Ahmadi Y; Davari M · Nutrition & metabolism · 2022
    Randomized trial120 participantsStress Relief forTaurine
  83. Effects of taurine supplementation on VDT work induced visual stress.
    Zhang M; Bi LF; Ai YD; Yang LP; Wang HB; Liu ZY; Sekine M; Kagamimori S · Amino acids · 2005
    Randomized trial25 participantsStress Relief forTaurine
  84. Taurine supplementation attenuates delayed increase in exercise-induced arterial stiffness.
    Ra SG; Choi Y; Akazawa N; Ohmori H; Maeda S · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017
    Randomized trial29 participantsStress Relief forTaurine