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B Complex Neuro Factors

Protocol For Life Balance
4.8
โ˜… โ˜… โ˜… โ˜… โ˜…
(321 ratings)
Betaine Anhydrous 50 mg
PABA 25 mg
Riboflavin 50 mg
Thiamin 50 mg
Vitamin B6 50 mg
Biotin 1000 mcg
Vitamin B5 50 mg
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Score77
Best suited to energy, with the clearest benefits coming from the disclosed active ingredients. The advanced B-complex uses activated and methylated forms, but several B vitamins are supplied at very high amounts while choline and specialty antioxidants are modest.
How scoring works
Quantity:60 Capsule(s) โ€ข (30 servings)
Goals:
Energy
General Health
Heart Health
Metabolism Boost
Cardiovascular Support
Mood Support
Cognitive Support

Score 77

Best suited to energy, with the clearest benefits coming from the disclosed active ingredients. The advanced B-complex uses activated and methylated forms, but several B vitamins are supplied at very high amounts while choline and specialty antioxidants are modest.
How scoring works
$32.00($1.06 per serving)
Pure Formulas
$ 32.00
Vitacost
$ 32.00
iHerb
$ 32.00
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Analysis

The advanced B-complex uses activated and methylated forms, but several B vitamins are supplied at very high amounts while choline and specialty antioxidants are modest. Prolonged high-dose vitamin B6 can contribute to nerve symptoms, and high niacin may cause flushing or other intolerance.

Active forms of thiamin, riboflavin, vitamin B6, folate, and vitamin B12 make this a strong metabolic B-complex. Alpha-lipoic acid provides a modest complementary cellular-energy pathway. CoQ10 is present at a token amount and does not add meaningful mitochondrial depth.

Active B-vitamin forms can support normal energy metabolism, but they do not provide calories, protein, creatine, or a meaningful muscle-building stimulus. Betaine anhydrous is present at only 50 mg, far below a performance-oriented amount. The formula is unsuitable as a weight-gain product because it cannot materially raise energy intake or muscle protein synthesis.

Who is it for
  • People seeking energy support
  • People seeking general health support
  • People seeking heart health support
Best for
  • Energy
  • General Health
  • Heart Health

Pros

  • Prolonged high-dose vitamin B6 can contribute to nerve symptoms, and high niacin may cause flushing or other intolerance.
  • Active forms of thiamin, riboflavin, vitamin B6, folate, and vitamin B12 make this a strong metabolic B-complex.
  • High vitamin B6 and niacin amounts also make the formula less suitable for indefinite daily use.
  • Activated folate, methylcobalamin, dibencozide, riboflavin phosphate, and pyridoxal phosphate provide high-quality B-vitamin support.
  • The formula is narrow for general health and its high vitamin B6 amount may be excessive for routine unsupervised use.

Cons

  • The advanced B-complex uses activated and methylated forms, but several B vitamins are supplied at very high amounts while choline and specialty antioxidants are modest.
  • Alpha-lipoic acid provides a modest complementary cellular-energy pathway.
  • CoQ10 is present at a token amount and does not add meaningful mitochondrial depth.
  • A small CoQ10 amount adds heart context but is unlikely to provide a strong cellular-energy contribution.
  • Cardiovascular coverage remains narrow because the formula lacks meaningful magnesium, omega-3s, or adequately dosed CoQ10.

Warnings

  • Prolonged high-dose vitamin B6 can contribute to nerve symptoms, and high niacin may cause flushing or other intolerance.
  • The formula is narrow for general health and its high vitamin B6 amount may be excessive for routine unsupervised use.
  • The forms are a clear strength, and the focused B-complex avoids much of the clutter found in broad multivitamins.
  • CoQ10 is too small for strong mitochondrial support, and no thyroid, glycemic, or thermogenic pathway is included.
  • Long-term daily use of the supplied B6 amount may cause tingling, numbness, or other nerve symptoms.

Nutrient quality

80 High impact

P-5-P, methylcobalamin, dibencozide, methylfolate, pantethine, and cocarboxylase are well-regarded active forms. Vitamin B6 and niacin are aggressive for routine long-term use.

Ingredient transparency

84 Highest impact

Listed active amounts are clear without a hidden proprietary dose. Complete directions and inactive-ingredient details remain incomplete.

Customer satisfaction

71 High impact

The aggregate rating and its volume provide a favorable top-level signal. Missing experience details prevent assessment of repeated complaints or purpose-specific satisfaction.

Value for money

70 High impact

Advanced coenzyme forms support some premium, but the serving remains costly. Comparable formulas can provide a better balance of forms, safety, and cost.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A- Goal FitA- Strength of SupportB- CoverageA- Formula Quality
Vitamin B5 ยท 50 mgRiboflavin ยท 50 mgThiamin ยท 50 mgVitamin B12 ยท 250 mcgCoenzyme Q-10 ยท 10 mg

Active forms of thiamin, riboflavin, vitamin B6, folate, and vitamin B12 make this a strong metabolic B-complex. Alpha-lipoic acid provides a modest complementary cellular-energy pathway.

CoQ10 is present at a token amount and does not add meaningful mitochondrial depth. High vitamin B6 and niacin amounts also make the formula less suitable for indefinite daily use.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
General Health
General Health
Impact
Highest effect
B+ Goal FitA Strength of SupportC CoverageA Formula Quality
Folate ยท 667 mcg DFEVitamin B12 ยท 250 mcgVitamin C ยท 60 mg

Activated folate, methylcobalamin, dibencozide, riboflavin phosphate, and pyridoxal phosphate provide high-quality B-vitamin support. The formula is narrow for general health and its high vitamin B6 amount may be excessive for routine unsupervised use.

Coverage centers on cellular energy and methylation rather than minerals, fatty acids, or broader nutritional gaps. The ingredients form a focused B-complex with useful cofactors and little unrelated padding.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Heart Health
Heart Health
Impact
High effect
B+ Goal FitB- Strength of SupportC CoverageA- Formula Quality
Coenzyme Q-10 ยท 10 mgVitamin B12 ยท 250 mcgVitamin B6 ยท 50 mgFolate ยท 667 mcg DFE

Active folate, P-5-P, methylcobalamin, and dibencozide make the B-vitamin core relevant to homocysteine metabolism. A small CoQ10 amount adds heart context but is unlikely to provide a strong cellular-energy contribution.

The forms are a clear strength, and the focused B-complex avoids much of the clutter found in broad multivitamins. Cardiovascular coverage remains narrow because the formula lacks meaningful magnesium, omega-3s, or adequately dosed CoQ10.

Study evidence
Coenzyme Q-10 Supportive 114 studies
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C+ Goal FitB Strength of SupportC CoverageB+ Formula Quality
Biotin ยท 1000 mcgNiacin ยท 100 mgVitamin B12 ยท 250 mcgRiboflavin ยท 50 mgThiamin ยท 50 mgVitamin B5 ยท 50 mgVitamin B6 ยท 50 mgCoenzyme Q-10 ยท 10 mg

Active B vitamins, alpha-lipoic acid, NAD-related niacin forms, and CoQ10 create a coherent cellular-energy formula. Precise coenzyme forms are a meaningful quality strength.

CoQ10 is too small for strong mitochondrial support, and no thyroid, glycemic, or thermogenic pathway is included. Long-term daily use of the supplied B6 amount may cause tingling, numbness, or other nerve symptoms.

Study evidence
Coenzyme Q-10 Disputed 11 studies
Niacin Supportive 17 studies
Riboflavin Mixed 5 studies
Thiamin Supportive 11 studies
Vitamin B12 Supportive 10 studies
Vitamin B6 Supportive 16 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
C Goal FitC+ Strength of SupportC- CoverageB- Formula Quality
Coenzyme Q-10 ยท 10 mgVitamin B12 ยท 250 mcgVitamin B6 ยท 50 mgFolate ยท 667 mcg DFENiacin ยท 100 mgVitamin C ยท 60 mg

Active vitamin B6, methylfolate, methylcobalamin, and betaine form a coherent homocysteine-support formula. The active forms and clear amounts are strong formulation features.

CoQ10 and betaine are too small to add much cardiac-energy or methylation depth beyond the B vitamins. The high vitamin B6 amount may be unsuitable for prolonged use because chronic excess can cause nerve problems.

Study evidence
Coenzyme Q-10 Supportive 89 studies
Folate Supportive 93 studies
Niacin Supportive 136 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies
Mood Support
Mood Support
Impact
High effect
C- Goal FitB- Strength of SupportC- CoverageB Formula Quality
Folate ยท 667 mcg DFEVitamin B6 ยท 50 mgVitamin B12 ยท 250 mcg

Active P-5-P, methylfolate, methylcobalamin, and dibencozide support neurotransmitter production and methylation. The B-vitamin forms are a clear strength for foundational brain nutrition.

Choline, inositol, and CoQ10 are present only in small supporting amounts. No adaptogen, omega-3, or direct mood active broadens the formula beyond metabolic support.

Study evidence
Folate Supportive 84 studies
Vitamin B12 Supportive 29 studies
Vitamin B6 Supportive 19 studies

Ingredients

IngredientAmount per serving
Vitamin C (Magnesium Ascorbate)
 60 mg
Thiamin (Cocarboxylase, Thiamine Hydrochloride)
 50 mg
Riboflavin (Riboflavin-5-Phosphate Sodium)
 50 mg
Niacin (Inositol Hexanicotinate, NAD Trihydrate, Vitamin B3)
 100 mg
Vitamin B-6 (P-5-P Monohydrate, Pyridoxine Hydrochloride)
 50 mg
Folate (Glucosamine Salt, Quatrefolic (6S)-5-MTHF)
 667 mcg DFE
Vitamin B12 (Methylcobalamin, Dibencozide)
 250 mcg
Biotin
1000 mcg
Pantothenic Acid (Calcium Pantothenate, Pantethine, Vitamin B5)
 50 mg
Choline (Choline Bitartrate)
 25 mg
Betaine Anhydrous
50 mg
Alpha Lipoic Acid
50 mg
PABA
25 mg
Inositol (Inositol Hexanicotinate, Inositol Hexaphosphate)
 30 mg
CoQ10
10 mg
Gluten Free Adults 18โ€“50 Vegan Dairy Free Vegetarian
Report overview
Betaine Anhydrous ยท 50 mg OverallScore87
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyB Value

Explicit Betaine Anhydrous provides the intended TMG form for methylation and cellular hydration. The 50 mg amount is a moderate wellness dose and is clearly listed as a standalone ingredient. Its below-median serving cost supports fair value, though the dose is not strong enough for the top value level.

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PABA ยท 25 mg OverallScore82
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

PABA is clearly named in a standard form, though no pharmaceutical-grade or high-purity claim is supplied, and the delivery format suits the dose. The clearly disclosed 25 mg amount suits a high-potency B-complex, and no targeted additives appear in the supplied ingredient data. PABA-specific cost efficiency is weak, so the broader formula must carry most of the value.

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Thiamin (Cocarboxylase, Thiamine Hydrochloride) ยท 50 mg OverallScore80
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

The formula combines thiamine hydrochloride with cocarboxylase and supplies a high-potency amount. A standard capsule format is practical, but the provided data does not establish a minimal-excipient delivery system. Its specialized B-vitamin blend may suit people seeking activated forms, though the cost is high for the thiamin delivered.

View ingredientView products
Loading alternative details
92 Performance

BioCoenzymated Active B Complex

Natural Factors
<p>Benfotiamine, riboflavin 5-phosphate, P-5-P, methylfolate, and methylcobalamin provide a focused active-form profile with a more moderate vitamin B6 amount than many high-potency formulas. Niacin remains substantial, but the formula avoids the originalโ€™s more aggressive combination of duplicate high-dose entries.</p>
90 Performance

B-Complex Plus

Pure Encapsulations
<p>Methylfolate, methylcobalamin, P-5-P, and activated riboflavin create a focused formula with a comparatively restrained vitamin B6 amount. Niacin remains elevated, but the shorter ingredient list avoids token extras and keeps the purpose clear.</p>
87 Performance

High Potency Vitamin B Complex

Lake Avenue Nutrition
<p>Active riboflavin, P-5-P, methylfolate, and methylcobalamin provide strong form quality with a modest vitamin B6 amount. The niacin declaration combines niacinamide and nicotinic acid without a clear split, so flushing, redness, or stomach upset remain possible.</p>
68 Budget

B-Complex '100'

Solgar
<p>A much lower serving cost provides a complete high-potency B-vitamin panel with useful biotin and inositol. Most forms are conventional, and 100 mg of pyridoxine reaches the chronic-use safety ceiling, so the savings do not make it a good unsupervised daily option.</p>
66 Budget

B-100

NOW
<p>A substantially lower serving cost retains broad B-vitamin coverage in a simple one-serving formula. Conventional forms and 100 mg of pyridoxine make it less refined than the original and raise concern about nerve symptoms with prolonged use.</p>
73 Budget

B-100 Complex with B2 Coenzyme

Nature's Way
<p>A lower serving cost adds active riboflavin and partial P-5-P while preserving broad B-100 coverage. The total vitamin B6 listing remains very high, and cyanocobalamin and several conventional forms make it less balanced for routine long-term use.</p>
88 Value

CellularActive Coenzyme B-Complex

Bluebonnet
<p>Coenzyme thiamine, riboflavin 5-phosphate, P-5-P, methylfolate, and methylcobalamin provide strong form quality at a modest serving cost. Mixed methylfolate and folic-acid entries plus elevated vitamin B6 reduce clarity, while small PABA and inositol amounts add little.</p>
85 Value

Coenzyme B-Complex Caps

Country Life
<p>Multiple coenzyme forms, methylfolate, two active vitamin B12 forms, and pantethine provide substantial formulation depth for the serving cost. Vitamin B6 remains elevated and choline is modest, so the value is strongest for selective rather than continuous high-dose use.</p>
83 Value

B-Complex

Paradise Earth's Blend
<p>Benfotiamine, riboflavin 5-phosphate, P-5-P, methylfolate, and methylcobalamin provide broad active-form coverage at a low serving cost. The vitamin B6 amount is high for prolonged unsupervised use, while the small greens, probiotic, and adaptogen blends add little measurable value.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals.
    Mizuno K; Sasaki AT; Watanabe K; Watanabe Y ยท Nutrients ยท 2021
    Clinical trial62 participantsEnergy forCoenzyme Q-10
  2. Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis.
    Deng H; Song T; Yin M; Xu K; Zhong Y; Mohd NB; Naharudin MNB; Yusof A; Fan X ยท The British journal of nutrition ยท 2026
    Meta-analysis24 studies pooledEnergy forCoenzyme Q-10
  3. Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials.
    Lei L; Liu Y ยท BMC cardiovascular disorders ยท 2018
    Meta-analysis2,149 participants14 studies pooledHeart Health forCoenzyme Q-10
  4. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.
    Ho MJ; Li EC; Wright JM ยท The Cochrane database of systematic reviews ยท 2016
    Meta-analysis50 participants3 studies pooledHeart Health forCoenzyme Q-10
  5. Effects of betaine on body composition, performance, and homocysteine thiolactone.
    Cholewa JM; Wyszczelska-Rokiel M; Glowacki R; Jakubowski H; Matthews T; Wood R; Craig SA; Paolone V ยท Journal of the International Society of Sports Nutrition ยท 2013
    Randomized trial23 participantsWeight Gain forBetaine Anhydrous
  6. Betaine supplementation fails to improve body composition: a systematic review and meta-analysis.
    Ashtary-Larky D; Bagheri R; Tinsley GM; Asbaghi O; Salehpour S; Kashkooli S; Kooti W; Wong A ยท The British journal of nutrition ยท 2023
    Meta-analysisWeight Gain forBetaine Anhydrous
  7. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
    Mortensen SA; Rosenfeldt F; Kumar A; Dolliner P; Filipiak KJ; Pella D; Alehagen U; Steurer G; Littarru GP; Q-SYMBIO Study Investigators ยท JACC. Heart failure ยท 2015
    Randomized trial420 participantsCardiovascular Support forCoenzyme Q-10
  8. Coenzyme Q10 for heart failure.
    Madmani ME; Yusuf Solaiman A; Tamr Agha K; Madmani Y; Shahrour Y; Essali A; Kadro W ยท The Cochrane database of systematic reviews ยท 2015
    Systematic review914 participants7 studies pooledCardiovascular Support forCoenzyme Q-10
  9. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
    Carmel R; Melnyk S; James SJ ยท Blood ยท 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  10. Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment.
    Kanti G; Anadol-Schmitz E; Bobrov P; Strassburger K; Kahl S; Zaharia OP; Sarabhai T; Karusheva Y; Burkart V; Markgraf DF; Trenkamp S; Ziegler D; Szendroedi J; Roden M; GDS Group ยท The Journal of clinical endocrinology and metabolism ยท 2021
    Cross-sectional study249 participantsMetabolism Boost forVitamin B12
  11. Plasma vitamin profiles and their associations with metabolic health and mental wellbeing in midlife Asian women.
    Tan KML; Tint MT; Cabral RM; Lau R; Kee MZL; Garg V; De Iorio M; Tan SSL; Eriksson JG ยท Scientific reports ยท 2026
    Cohort study662 participantsMetabolism Boost forThiamin
  12. Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials.
    Nakanishi N; Abe Y; Matsuo M; Tampo A; Yamada K; Hatakeyama J; Yoshida M; Yamamoto R; Higashibeppu N; Nakamura K; Kotani J ยท Clinical nutrition (Edinburgh, Scotland) ยท 2024
    Meta-analysis3,494 participants35 studies pooledMetabolism Boost forThiamin
  13. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A ยท Nutrients ยท 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  14. Double-blind trial of pyridoxine (vitamin B6) in the treatment of steroid-dependent asthma.
    Sur S; Camara M; Buchmeier A; Morgan S; Nelson HS ยท Annals of allergy ยท 1993
    Randomized trial31 participantsMetabolism Boost forVitamin B6
  15. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K ยท The Proceedings of the Nutrition Society ยท 2026
    Narrative reviewMetabolism Boost forRiboflavin
  16. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH ยท The international journal of biochemistry & cell biology ยท 2024
    Systematic reviewMetabolism Boost forRiboflavin
  17. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
    Liu Z; Tian Z; Zhao D; Liang Y; Dai S; Liu M; Hou S; Dong X; Zhaxinima; Yang Y ยท The Journal of clinical endocrinology and metabolism ยท 2022
    Meta-analysis2,794 participants50 studies pooledCardiovascular Support Heart Health forCoenzyme Q-10
  18. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
    Vrentzos E; Ikonomidis I; Pavlidis G; Katogiannis K; Korakas E; Kountouri A; Pliouta L; Michalopoulou E; Pelekanou E; Boumpas D; Lambadiari V ยท Cardiovascular diabetology ยท 2024
    Randomized trial60 participantsCardiovascular Support forCoenzyme Q-10
  19. [Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
    Mareev VY; Mareev YV; Begrambekova YL ยท Kardiologiia ยท 2022
    Meta-analysis1,139 participants6 studies pooledCardiovascular Support forCoenzyme Q-10
  20. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
    Mortensen AL; Rosenfeldt F; Filipiak KJ ยท Cardiology journal ยท 2020
    Randomized trialCardiovascular Support forCoenzyme Q-10
  21. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L ยท European journal of clinical nutrition ยท 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  22. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J ยท Journal of the American Heart Association ยท 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  23. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ ยท The American journal of cardiology ยท 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  24. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH ยท Journal of internal medicine ยท 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  25. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ ยท Circulation ยท 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  26. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH ยท Journal of the American College of Cardiology ยท 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  27. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S ยท The British journal of nutrition ยท 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  28. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group ยท Atherosclerosis ยท 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  29. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group.
    Guyton JR; Blazing MA; Hagar J; Kashyap ML; Knopp RH; McKenney JM; Nash DT; Nash SD ยท Archives of internal medicine ยท 2000
    Randomized trial173 participantsCardiovascular Support forNiacin
  30. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia.
    Knopp RH; Alagona P; Davidson M; Goldberg AC; Kafonek SD; Kashyap M; Sprecher D; Superko HR; Jenkins S; Marcovina S ยท Metabolism: clinical and experimental ยท 1998
    Randomized trial223 participantsCardiovascular Support forNiacin
  31. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; ลžahin F; Tay ฤฐ; Yฤฑldฤฑrฤฑm Saral N; Serteser M; Baykal AT ยท Journal of clinical medicine ยท 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  32. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP ยท Hypertension (Dallas, Tex. : 1979) ยท 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  33. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I ยท Nutrients ยท 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  34. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y ยท Journal of clinical biochemistry and nutrition ยท 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  35. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S ยท Journal of cardiac surgery ยท 2021
    Systematic reviewCardiovascular Support forVitamin B12
  36. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW ยท Therapeutic advances in chronic disease ยท 2024
    Cohort studyCardiovascular Support forVitamin B6
  37. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ ยท Pediatrics ยท 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  38. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ ยท The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation ยท 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  39. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ ยท JAMA ยท 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  40. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC ยท JAMA ยท 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  41. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M ยท Clinical therapeutics ยท 2003
    Randomized trial261 participantsCognitive Support forCholine
  42. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D ยท The American journal of clinical nutrition ยท 2025
    Cohort study125,594 participantsCognitive Support forCholine
  43. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E ยท American journal of epidemiology ยท 2013
    Cohort study895 participantsCognitive Support forCholine
  44. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S ยท Diabetes, obesity & metabolism ยท 2025
    Randomized trial36 participantsCognitive Support forCholine
  45. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zรถllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM ยท Alcoholism, clinical and experimental research ยท 2022
    Randomized trial52 participantsCognitive Support forCholine
  46. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
    Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS ยท Frontiers in endocrinology ยท 2021
    Systematic review46 studies pooledCognitive Support forVitamin B12
  47. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
    Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K ยท Maternal and child health journal ยท 2019
    Randomized trial218 participantsCognitive Support forVitamin B12
  48. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G ยท Current Alzheimer research ยท 2020
    Randomized trial240 participantsCognitive Support forVitamin B12
  49. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q ยท Nutricion hospitalaria ยท 2023
    Randomized trial115 participantsCognitive Support forVitamin B12
  50. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodrรญguez J; Canals-Sans J; Hernรกndez-Martรญnez C; Voltas-Moreso N; Arija V ยท Maternal & child nutrition ยท 2023
    Cohort study249 participantsCognitive Support forVitamin B12
  51. Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.
    Zhuo C; Xu Y; Wang H; Fang T; Chen J; Zhou C; Li Q; Liu J; Xu S; Yao C; Yang W; Yang A; Li B; Chen Y; Tian H; Lin C ยท Frontiers in psychiatry ยท 2021
    Randomized trial200 participantsCognitive Support forVitamin B6
  52. Associations between dietary B vitamin intakes and cognitive function among elderly individuals: An observational study.
    Chen Q; Huang J; Shi X; Peng Y; Chen A; Huang L; Zhang Y; Chen X ยท Nutrition (Burbank, Los Angeles County, Calif.) ยท 2025
    Cross-sectional study2,716 participantsCognitive Support forVitamin B6
  53. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL ยท The Journal of nutrition ยท 2020
    Cohort study949 participantsCognitive Support forVitamin B6
  54. Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases.
    Zhang C; Hu Y; Cao X; Deng Y; Wang Y; Guan M; Wu X; Jiang H ยท Scientific reports ยท 2025
    Cohort study926 participantsCognitive Support forVitamin B6
  55. Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
    Gordon S; Hoey L; McNulty H; Keenan J; Pangilinan F; Brody LC; Ward M; Strain JJ; McAnena L; McCann A; Molloy AM; Cunningham C; McCarroll K; Hughes CF ยท BMC medicine ยท 2025
    Observational study4,553 participantsCognitive Support forVitamin B6
  56. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ ยท Journal of the American Heart Association ยท 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  57. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigรฒ LP ยท Nutrients ยท 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  58. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV ยท Frontiers in pharmacology ยท 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  59. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y ยท Nutrition (Burbank, Los Angeles County, Calif.) ยท 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  60. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A ยท Complementary therapies in medicine ยท 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  61. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A ยท Heliyon ยท 2021
    Non-randomized trialEnergy forRiboflavin
  62. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S ยท Journal of the Royal Society of Medicine ยท 1999
    Case-control study30 participantsEnergy forRiboflavin
  63. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF ยท Molecular medicine (Cambridge, Mass.) ยท 2023
    Observational studyEnergy forRiboflavin
  64. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E ยท Proceedings of the National Academy of Sciences of the United States of America ยท 2024
    Case-control study84 participantsEnergy forRiboflavin
  65. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch ยท Journal of Inherited Metabolic Disease ยท 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  66. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ ยท Journal of gerontology ยท 1991
    Randomized trial80 participantsEnergy forThiamin
  67. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF ยท Alimentary pharmacology & therapeutics ยท 2021
    Randomized trial40 participantsEnergy forThiamin
  68. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjรถdin A; Stern M; Tomรฉ D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarrรฉ A; Forss AC; Neuhรคuser-Berthold M ยท EFSA journal. European Food Safety Authority ยท 2026
    Guideline / consensusEnergy forThiamin
  69. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y ยท Metabolic brain disease ยท 1996
    Randomized trial16 participantsEnergy forThiamin
  70. Long-term maintenance treatment with 300โ€‰mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF ยท Scandinavian journal of gastroenterology ยท 2022
    Randomized trialEnergy forThiamin
  71. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Duล‚ak NA; Rytlewska M; Jaskรณlska M; Chmielewski M ยท Rheumatology international ยท 2024
    Case series3 participantsEnergy forVitamin B12
  72. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jรคger L; Rosemann T; Pichierri G; Burgstaller JM ยท Nutrients ยท 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  73. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B ยท Brain circulation ยท 2024
    Qualitative study5 participantsEnergy forVitamin B12
  74. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F ยท Nutrients ยท 2014
    Narrative reviewEnergy forVitamin B12
  75. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R ยท American family physician ยท 2025
    Narrative reviewEnergy forVitamin B12
  76. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z ยท Nutrients ยท 2022
    Cohort study55,569 participantsGeneral Health forFolate
  77. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC ยท European journal of clinical nutrition ยท 1998
    Randomized trial119 participantsGeneral Health forFolate
  78. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY ยท The Journal of nutrition ยท 2023
    Cohort study21,260 participantsGeneral Health forFolate
  79. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F ยท Medicine ยท 2024
    Systematic reviewGeneral Health forFolate
  80. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS ยท Journal of public health (Oxford, England) ยท 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  81. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N ยท Asian Pacific journal of cancer prevention : APJCP ยท 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  82. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K ยท Nutrients ยท 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  83. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX ยท Pain medicine (Malden, Mass.) ยท 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  84. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xว” G; Xu S; Tang WZ; Xรบ G; Cheng C; Xu J ยท Pain medicine (Malden, Mass.) ยท 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  85. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N ยท Clinical nutrition research ยท 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  86. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N ยท Cureus ยท 2025
    Randomized trial105 participantsHair Health Skin Health forBiotin
  87. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S ยท Epilepsia ยท 2001
    Clinical trial125 participantsHair Health Skin Health forBiotin
  88. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A ยท Alternative therapies in health and medicine ยท 2021
    Narrative reviewHair Health forBiotin
  89. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J ยท Journal of drugs in dermatology : JDD ยท 2018
    Narrative reviewHair Health forBiotin
  90. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative ยท Obesity surgery ยท 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  91. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I ยท Diseases (Basel, Switzerland) ยท 2025
    Case-control study200 participantsHair Health forFolate
  92. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J ยท British journal of cancer ยท 2003
    Randomized trialHair Health forFolate
  93. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontarioโ€™s Program in Evidence-Based Care ยท Current oncology (Toronto, Ont.) ยท 2012
    Randomized trialHair Health forFolate
  94. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolรจ F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A ยท Annals of oncology : official journal of the European Society for Medical Oncology ยท 1997
    Randomized trialHair Health forFolate
  95. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial.
    Sabbatinelli J; Orlando P; Galeazzi R; Silvestri S; Cirilli I; Marcheggiani F; Dludla PV; Giuliani A; Bonfigli AR; Mazzanti L; Olivieri F; Antonicelli R; Tiano L ยท Nutrients ยท 2021
    Randomized trial51 participantsHeart Health forCoenzyme Q-10
  96. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Zhao D; Liang Y; Dai S; Hou S; Liu Z; Liu M; Dong X; Zhan Y; Tian Z; Yang Y ยท Advances in nutrition (Bethesda, Md.) ยท 2022
    Meta-analysis1,831 participants26 studies pooledHeart Health forCoenzyme Q-10
  97. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M ยท Journal of diabetes research ยท 2026
    Meta-analysis3,422 participants64 studies pooledHeart Health Metabolism Boost forCoenzyme Q-10
  98. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.
    Zhang P; Yang C; Guo H; Wang J; Lin S; Li H; Yang Y; Ling W ยท Journal of clinical lipidology ยท 2019
    Randomized trial101 participantsHeart Health forCoenzyme Q-10
  99. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y ยท Stroke ยท 2017
    Randomized trial20,702 participantsHeart Health forFolate
  100. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group ยท Annals of internal medicine ยท 2022
    Case-control study985 participantsHeart Health forFolate
  101. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS ยท Critical reviews in food science and nutrition ยท 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  102. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A ยท Nutrition reviews ยท 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  103. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M ยท SAGE open medicine ยท 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  104. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstrรฅle M; Vistisen D; Jรธrgensen ME; Fleischer J ยท Journal of diabetes and its complications ยท 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  105. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC ยท BJOG : an international journal of obstetrics and gynaecology ยท 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  106. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D ยท Clinical autonomic research : official journal of the Clinical Autonomic Research Society ยท 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  107. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF ยท Journal of human hypertension ยท 2024
    Observational study596 participantsHeart Health forVitamin B12
  108. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group ยท Journal of the American College of Nutrition ยท 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  109. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q ยท Nutrition reviews ยท 2024
    Meta-analysisHeart Health forVitamin B6
  110. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C ยท European journal of clinical nutrition ยท 2005
    Case-control study985 participantsHeart Health forVitamin B6
  111. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.
    Zhang P; Chen K; He T; Guo H; Chen X ยท Nutrition & metabolism ยท 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  112. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y ยท PeerJ ยท 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forCoenzyme Q-10
  113. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ ยท Food & function ยท 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  114. The effect of coenzyme Q10 intake on metabolic profiles in women candidates for in-vitro fertilization: a randomised trial.
    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M ยท Annals of medicine and surgery (2012) ยท 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10
  115. Niacin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) ยท EFSA journal. European Food Safety Authority ยท 2026
    Guideline / consensusMetabolism Boost forNiacin
  116. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans.
    Fangmann D; Theismann EM; Tรผrk K; Schulte DM; Relling I; Hartmann K; Keppler JK; Knipp JR; Rehman A; Heinsen FA; Franke A; Lenk L; Freitag-Wolf S; Appel E; Gorb S; Brenner C; Seegert D; Waetzig GH; Rosenstiel P; Schreiber S; Schwarz K; Laudes M ยท Diabetes care ยท 2018
    Clinical trialMetabolism Boost forNiacin
  117. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.
    Christen S; Redeuil K; Goulet L; Giner MP; Breton I; Rota R; Frรฉzal A; Nazari A; Van den Abbeele P; Godin JP; Nutten S; Cuenoud B ยท Nature metabolism ยท 2026
    Randomized trial65 participantsMetabolism Boost forNiacin
  118. Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance.
    Linke A; Sonnabend M; Fasshauer M; Hรถllriegel R; Schuler G; Niebauer J; Stumvoll M; Blรผher M ยท Atherosclerosis ยท 2009
    Randomized trial30 participantsMetabolism Boost forNiacin
  119. Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.
    Vaag A; Skรถtt P; Damsbo P; Gall MA; Richter EA; Beck-Nielsen H ยท The Journal of clinical investigation ยท 1991
    Clinical trial12 participantsMetabolism Boost forNiacin
  120. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A ยท The American journal of the medical sciences ยท 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  121. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guรฉant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M ยท The American journal of clinical nutrition ยท 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  122. Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults.
    Dhir S; Tarasenko M; Napoli E; Giulivi C ยท Frontiers in psychiatry ยท 2026
    Narrative reviewMetabolism Boost forThiamin
  123. High-resolution plasma metabolomics and thiamine status in critically Ill adult patients.
    Gundogan K; Nellis MM; Ozer NT; Ergul SS; Sahin GG; Temel S; Yuksel RC; Teeny S; Alvarez JA; Sungur M; Jones DP; Ziegler TR ยท Metabolomics : Official journal of the Metabolomic Society ยท 2024
    Cross-sectional study76 participantsMetabolism Boost forThiamin
  124. Pathophysiology, prevention, and treatment of beriberi after gastric surgery.
    Wilson RB ยท Nutrition reviews ยท 2021
    Narrative reviewMetabolism Boost forThiamin
  125. Red blood cell transketolase activity and the effect of thiamine supplementation in patients with chronic liver disease.
    Rossouw JE; Labadarios D; Krasner N; Davis M; Williams R ยท Scandinavian journal of gastroenterology ยท 1978
    Single-arm trialMetabolism Boost forThiamin
  126. Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study).
    Saravanan P; Sukumar N; Adaikalakoteswari A; Goljan I; Venkataraman H; Gopinath A; Bagias C; Yajnik CS; Stallard N; Ghebremichael-Weldeselassie Y; Fall CHD ยท Diabetologia ยท 2022
    Cohort study4,746 participantsMetabolism Boost forVitamin B12
  127. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
    Olivieri G; Bordugo A; Burnyte B; Costetti A; Couce ML; Diogo L; Feillet F; Froese DS; Greco B; Gueant JL; Hannibal L; Hรถrster F; Koลพich V; La Marca G; Manoli I; Mochel F; Orazi L; Pรฉrez B; Schiff M; Schwahn BC; Schwartz I; Stepien KM; Sykut-Cegielska J; Tangeraas T; Zetterstrรถm RH; Dionisi-Vici C; Huemer M ยท Journal of inherited metabolic disease ยท 2026
    Guideline / consensusMetabolism Boost forVitamin B12
  128. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D ยท Frontiers in pharmacology ยท 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
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    Kanvinde P; Khurana R; Mudaliar S ยท Frontiers in nutrition ยท 2026
    Narrative reviewMetabolism Boost forVitamin B12
  130. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
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    Randomized trial90 participantsMetabolism Boost forVitamin B6
  131. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X ยท European journal of clinical nutrition ยท 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  132. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M ยท Lancet (London, England) ยท 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  133. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM ยท The American journal of clinical nutrition ยท 1975
    Clinical trialMetabolism Boost forVitamin B6
  134. The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials.
    Firth J; Teasdale SB; Allott K; Siskind D; Marx W; Cotter J; Veronese N; Schuch F; Smith L; Solmi M; Carvalho AF; Vancampfort D; Berk M; Stubbs B; Sarris J ยท World psychiatry : official journal of the World Psychiatric Association (WPA) ยท 2025
    Systematic review10,951 participants33 studies pooledMood Support forFolate
  135. Continuous supplementation of folic acid in pregnancy and the risk of perinatal depression-A meta-analysis.
    Jin X; Cheng Z; Yu X; Tao Q; Huang R; Wang S ยท Journal of affective disorders ยท 2022
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  136. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials.
    Borges-Vieira JG; Cardoso CKS ยท Nutritional neuroscience ยท 2023
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  137. Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses.
    Gao S; Khalid A; Amini-Salehi E; Radkhah N; Jamilian P; Badpeyma M; Zarezadeh M ยท Food science & nutrition ยท 2024
    Meta-analysis11 studies pooledMood Support forFolate
  138. Oral 5'-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study.
    Passeri M; Cucinotta D; Abate G; Senin U; Ventura A; Stramba Badiale M; Diana R; La Greca P; Le Grazie C ยท Aging (Milan, Italy) ยท 1993
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  139. Subjective well-being in older adults: folate and vitamin B12 independently predict positive affect.
    Edney LC; Burns NR; Danthiir V ยท The British journal of nutrition ยท 2016
    Cohort study391 participantsMood Support forVitamin B12
  140. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study.
    Cruz-Rodrรญguez J; Canals-Sans J; Hernรกndez-Martรญnez C; Arija V ยท Journal of reproductive and infant psychology ยท 2025
    Cohort study336 participantsMood Support forVitamin B12
  141. The biological relationship among depression, vitamins B9, B12, and D, and genetic variants: a systematic review.
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  142. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D ยท International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition ยท 2023
    Observational study17,732 participantsMood Support forVitamin B12 Mood Support forVitamin B6
  143. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N ยท Depression and anxiety ยท 2026
    Randomized trial267 participantsMood Support forVitamin B6
  144. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM ยท International journal of preventive medicine ยท 2022
    Randomized trial81 participantsMood Support forVitamin B6
  145. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G ยท Brain and behavior ยท 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  146. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
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    Cohort study88 participantsMood Support forVitamin B6
  147. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS ยท International journal of dermatology ยท 2021
    Non-randomized trial60 participantsSkin Health forBiotin
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    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N ยท Archives of disease in childhood ยท 1976
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  150. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
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  151. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M ยท Aesthetic plastic surgery ยท 2021
    Randomized trial149 participantsSkin Health forVitamin C
  152. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE ยท Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie ยท 2022
    Randomized trial25 participantsSkin Health forVitamin C
  153. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V ยท The British journal of nutrition ยท 2022
    Randomized trial16 participantsSkin Health forVitamin C
  154. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE ยท The American journal of clinical nutrition ยท 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C