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Peptiva + Sleep Support

Peptiva
4.1
★ ★ ★ ★ ★
(4655 ratings)
GABA 100 mg
Valerian 50 mg
Melatonin 0.75 mg
Product Image
Score59
Branded GABA and low-dose melatonin make a sensible nighttime core, but valerian is modest and the probiotic matrix is opaque. Duplicate melatonin entries need label verification.
How scoring works
Quantity:30 Capsule(s) • (30 servings)
Goals:
Sleep Support
Stress Relief
Brain Health

Score 59

Branded GABA and low-dose melatonin make a sensible nighttime core, but valerian is modest and the probiotic matrix is opaque. Duplicate melatonin entries need label verification.
How scoring works
$21.99($0.73 per serving)
iHerb
$ 49.99
Amazon
$ 21.99
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Analysis

The capsule supplies PharmaGABA, valerian, and a low melatonin amount suited to sleep onset. The supplied data shows duplicate 0.75 mg melatonin entries, so the physical label should be checked to confirm whether the total is 0.75 mg or 1.5 mg.

PharmaGABA is a useful branded source, but 100 mg is at the low end, while 50 mg of valerian is a supporting amount. The probiotic matrix lists only a 64 mg weight with no strains or viable-organism count.

One capsule is convenient, though the serving cost is high for the disclosed nighttime actives. The product mainly fits users who value low-dose melatonin and can verify both the melatonin total and probiotic specifications.

Who is it for
  • Adults seeking low-dose melatonin with PharmaGABA
  • Users who prefer one capsule
  • People who can verify the label’s melatonin total
Best for
  • Sleep-onset support
  • A low-dose melatonin routine
  • Combining PharmaGABA with mild valerian support

Pros

  • Uses branded PharmaGABA
  • Keeps melatonin relatively low
  • Identifies valerenic acids
  • Uses one capsule
  • Combines calming and probiotic concepts

Cons

  • Valerian is lightly dosed
  • The probiotic matrix hides strains and viable count
  • Duplicate melatonin entries create ambiguity
  • Serving cost is high
  • No extended-release feature is stated

Warnings

  • Verify whether the duplicate melatonin entries represent one total or two separate amounts before use.
  • Melatonin, GABA, and valerian may add to alcohol or sedative medicines and cause excess drowsiness.
  • Do not drive or operate machinery after taking the capsule.
  • People with severe immune compromise should seek guidance before using an unspecified live-microorganism blend.

Nutrient quality

71 High impact

Branded PharmaGABA and marker-named valerian improve form quality within the sleep blend. The melatonin amount is restrained, while GABA and valerian provide only modest supporting doses.

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Ingredient transparency

56 Moderate impact

Named sleep actives have amounts, but the probiotic matrix is not fully quantified by strain. The proprietary probiotic matrix hides strain-level amounts and viable-organism details.

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Customer satisfaction

57 Moderate impact

The supplied aggregate rating is mixed, and no specific comments explain the result. The large rating count makes the aggregate result relatively stable.

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Value for money

50 Moderate impact

Formula quality provides reasonable support for the product positioning. Serving utility appears weak, while low-value or lightly dosed extras reduce efficiency.

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Goals

Sleep Support
Sleep Support
Impact
Highest effect
B+ Goal FitB Strength of SupportA- CoverageB+ Formula Quality
Melatonin · 0.75 mg

Melatonin, PharmaGABA, and standardized valerian address circadian signaling, relaxation, and botanical calming in one bedtime capsule. The combination is sleep specific and uses clearly identified active forms.

GABA at 100 mg and valerian at 50 mg are modest, so melatonin likely carries much of the practical effect. Combining all three calming agents may cause excess drowsiness, and the proprietary probiotic matrix adds uncertain sleep value.

Study evidence
GABA Supportive 4 studies
Melatonin Supportive 181 studies
Valerian Supportive 31 studies
Stress Relief
Stress Relief
Impact
High effect
C Goal FitC+ Strength of SupportC+ CoverageB- Formula Quality
GABA · 100 mg

Branded PharmaGABA, valerian, and low-dose melatonin create a targeted nighttime calming formula. The combination may help when stress mainly appears as difficulty winding down, but it is less suited to daytime stress relief.

GABA is present at a modest blend dose, while the valerian amount is quite low despite active-marker disclosure. Combining these calming agents with melatonin may increase drowsiness, so the capsule is best reserved for bedtime.

Study evidence
GABA Supportive 6 studies
Melatonin Supportive 21 studies
Valerian Supportive 18 studies
Brain Health
Brain Health
Impact
Moderate effect
C- Goal FitC+ Strength of SupportC CoverageC+ Formula Quality

Low-dose melatonin, PharmaGABA, and valerian support sleep and relaxation, which may improve cognitive recovery. A probiotic matrix adds a possible gut-brain component.

The probiotic blend lacks strain and viable-organism details, while valerian is modest and its active standardization is unclear. Combining melatonin, GABA, and valerian may cause nighttime or next-morning drowsiness in sensitive users.

Study evidence
Melatonin Supportive 29 studies

Ingredients

IngredientAmount per serving
Proprietary Probiotic Matrix
64 mg
Gamma-Aminobutyric Acid (PharmaGABA)
 100 mg
Valerian (Valerenic Acids)
 50 mg
Melatonin
0.75 mg
Gluten Free Adults 18–50
Report overview
GABA (PharmaGABA) · 100 mg OverallScore78
A Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD- Value

Branded fermented PharmaGABA provides a well-defined source, but the amount is at the low end and is delivered in a standard capsule. Melatonin and valerian make the blend more specific to nighttime use and may add drowsiness. The premium source is offset by weak value per serving.

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Valerian (Valerenic Acids) · 50 mg OverallScore65
A+ Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyF Value

Valerenic acids are specifically identified, which gives useful insight into the active portion of the valerian ingredient. The 50 mg valerian amount is low for a dedicated valerian supplement, even though one capsule keeps use simple. Valerian combined with melatonin and GABA may cause drowsiness, so the high serving cost is difficult to justify for routine use.

View ingredientView products
Melatonin · 0.75 mg OverallScore64
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value

The 0.75 mg dose is physiologically aligned and clearly provided in one capsule. Standard capsule delivery and immediate release favor sleep onset more than overnight maintenance. The multi-ingredient sleep formula partly supports its premium cost, but independent purity certification is absent.

View ingredientView products
Loading alternative details
76 Performance

Best-Rest Formula

Pure Encapsulations
<p>Branded L-theanine, active vitamin B6, substantial GABA, valerian, and several calming herbs create a technically strong sleep blend. Stronger sleep alignment or more substantial ingredient coverage improves the comparison with the original, while dose disclosure and multi-ingredient complexity still deserve attention.</p>
79 Performance

Sleep Optimizer

Jarrow Formulas
<p>Valerian, tryptophan, GABA, calming herbs, and low-dose melatonin form a coherent sleep blend. Stronger sleep alignment or more substantial ingredient coverage improves the comparison with the original, while dose disclosure and multi-ingredient complexity still deserve attention.</p>
77 Performance

Lights Out Sleep

ALLMAX
<p>A varied sleep blend provides useful valerian, GABA, melatonin, and active vitamin B6. Stronger sleep alignment or more substantial ingredient coverage improves the comparison with the original, while dose disclosure and multi-ingredient complexity still deserve attention.</p>
71 Budget

Sleep Essentials

Swanson
<p>Melatonin carries most of the likely sleep effect because the many supporting actives are lightly dosed. The lower serving cost retains relevant sleep-support ingredients, but the narrower formula does not reproduce the original’s full combination.</p>
68 Budget

Super Snooze Melatonin with Herbal Blend

Sundown Naturals
<p>Melatonin provides direct sleep support, while the accompanying herbs and minerals are mostly modest. The lower serving cost retains relevant sleep-support ingredients, but the narrower formula does not reproduce the original’s full combination.</p>
78 Budget

Sleep

NOW
<p>Substantial valerian, hops, passionflower, and GABA create a focused nighttime calming blend. The lower serving cost retains relevant sleep-support ingredients, but the narrower formula does not reproduce the original’s full combination.</p>
75 Value

Sleep 'n Restore

Natrol
<p>Melatonin provides the clearest sleep support, while valerian and glutamine are supplied at modest amounts. Relevant sleep and relaxation ingredients at a lower serving cost improve practical value, with narrower pathway coverage or incomplete extract details as the trade-off.</p>
72 Value

Power to Sleep PM

Irwin Naturals
<p>Valerian, ashwagandha, hops, lemon balm, passionflower, and melatonin create broad nighttime support. Relevant sleep and relaxation ingredients at a lower serving cost improve practical value, with narrower pathway coverage or incomplete extract details as the trade-off.</p>
68 Value

Rest-ZZZ Melatonin-Free

LifeSeasons
<p>The melatonin-free blend combines several sensible calming pathways for nighttime use. Relevant sleep and relaxation ingredients at a lower serving cost improve practical value, with narrower pathway coverage or incomplete extract details as the trade-off.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  2. Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
    Ell J; Schmid SR; Benz F; Spille L · Journal of sleep research · 2024
    Systematic review15 studies pooledSleep Support forValerian
  3. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  4. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  5. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  6. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  7. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  8. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  9. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  10. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  11. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  12. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  13. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  14. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  15. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  16. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  17. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  18. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsSleep Support Stress Relief forValerian
  19. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  20. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
    Randomized trial40 participantsSleep Support forValerian
  21. Valerian for sleep: a systematic review and meta-analysis.
    Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
    Meta-analysis1,093 participants16 studies pooledSleep Support forValerian
  22. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief forGABA
  23. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  24. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  25. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA
  26. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
    Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
    Randomized trial202 participantsStress Relief forMelatonin
  27. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
    Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
    Randomized trial90 participantsStress Relief forMelatonin
  28. Melatonin for pre- and postoperative anxiety in adults.
    Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
    Meta-analysis774 participants12 studies pooledStress Relief forMelatonin
  29. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
    Meta-analysis441 participants5 studies pooledStress Relief forMelatonin
  30. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
    Randomized trial88 participantsStress Relief forMelatonin
  31. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
    Randomized trial54 participantsStress Relief forValerian
  32. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledStress Relief forValerian
  33. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
  34. Stress-induced insomnia treated with kava and valerian: singly and in combination.
    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian