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Revitalizing Sleep Formula

Nature's Way
4.0
★ ★ ★ ★ ★
(376 ratings)
Theanine 200 mg
Valerian 800 mg
5-HTP 200 mg
Product Image
Score68
Substantial doses provide strong sleep-oriented coverage. Serotonin interactions, next-day drowsiness, four capsules, and a short supply are major trade-offs.
How scoring works
Quantity:90 Capsule(s) • (22 servings)
Goals:
Sleep Support
Mood Support
Stress Relief
Brain Health
Productivity Boost

Score 68

Substantial doses provide strong sleep-oriented coverage. Serotonin interactions, next-day drowsiness, four capsules, and a short supply are major trade-offs.
How scoring works
$28.14($1.27 per serving)
Vitacost
$ 32.33
Vitacost
$ 32.33
iHerb
$ 29.39
Pure Formulas
$ 28.14
Report prices

Analysis

Four capsules provide 800 mg valerian extract, 200 mg 5-HTP, 200 mg L-theanine, 360 mg passionflower, 120 mg hops, and 80 mg lemon balm. The amounts are substantial, with 5-HTP and theanine both reaching strong supplemental levels.

Several ingredients may reinforce sleep onset and evening calm through complementary pathways. Valerian marker percentage is missing, and the combined sedating burden may create next-morning grogginess rather than better daytime cognition or productivity.

Only 22 servings are included, and four capsules make the routine cumbersome and expensive. It fits short-term, carefully screened nighttime use rather than casual daily stress support.

Who is it for
  • Adults seeking a high-potency sleep capsules
  • Users whose needs match the disclosed ingredient amounts
  • People who can screen ingredient-specific medication and tolerance concerns
Best for
  • Comparing form, dose, and practical value
  • Goal-aligned supplement selection
  • Users who prefer a high-potency sleep capsules

Pros

  • Provides 200 mg 5-HTP
  • Provides 200 mg L-theanine
  • High valerian and passionflower amounts
  • Covers several sleep pathways

Cons

  • Only 22 servings
  • Requires four capsules
  • High serving cost
  • Valerian marker strength is not stated
  • Poor fit for daytime focus or productivity

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, triptans, or other serotonin-modulating medicines
  • The combined valerian, hops, passionflower, lemon balm, and theanine may cause substantial drowsiness or next-morning impairment
  • Avoid alcohol, sedatives, and driving after the serving
  • The 200 mg 5-HTP amount may cause nausea or vivid dreams

Nutrient quality

77 High impact

Theanine and 5-HTP have substantial amounts, while valerian is unusually high and its marker percentage is missing. Multiple sedating ingredients create strong depth but also a high burden of drowsiness and interaction risk.

Ingredient transparency

80 Highest impact

Listed active ingredients have specific weights and no proprietary blend hides their doses. Complete use directions and a full other-ingredients list are not included in the supplied facts.

Customer satisfaction

59 Moderate impact

The supplied average rating is mixed, and review volume provides a useful but limited signal. No detailed comments are provided to assess repeated complaints or whether experiences match the intended use.

Value for money

49 Lower impact

Weak dose efficiency or high recurring cost limits practical value. Incomplete form, activity, or use details remain the main value trade-off.

Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A Goal FitA Strength of SupportA CoverageA Formula Quality
Theanine · 200 mg

Theanine, valerian, passionflower, 5-HTP, hops, and lemon balm directly target mental relaxation and sleep onset. The main actives are supplied at substantial and clearly stated amounts.

Valerian marker strength is not disclosed, and the high amount may cause next-morning grogginess in sensitive users. The 5-HTP amount can interact with serotonin-raising medicines, including selective serotonin reuptake inhibitors, because both increase serotonin activity.

Study evidence
5-HTP Supportive 1 study
Theanine Supportive 8 studies
Valerian Supportive 31 studies
Mood Support
Mood Support
Impact
Highest effect
A- Goal FitA Strength of SupportB+ CoverageA- Formula Quality
5-HTP · 200 mg

A well-dosed combination of 5-HTP and calming ingredients directly targets mood-related and sleep pathways. The strong sedative emphasis makes the formula more suitable for nighttime use than daytime mood support.

Clear amounts and a standardized valerian extract strengthen confidence in the formula. 5-HTP can interact with serotonergic medicines, and the calming stack may increase drowsiness.

Study evidence
5-HTP Supportive 9 studies
Theanine Supportive 12 studies
Valerian Supportive 17 studies
Stress Relief
Stress Relief
Impact
Highest effect
A- Goal FitB+ Strength of SupportB+ CoverageA- Formula Quality
Theanine · 200 mg

L-theanine at 200 mg, 5-HTP at 200 mg, valerian, passionflower, hops, and lemon balm create strong multi-pathway support for relaxation and sleep. Theanine is well dosed, while several sedative herbs are substantial.

Valerian at 800 mg may cause next-morning grogginess, and overlapping sedative ingredients may intensify drowsiness. The 5-HTP amount can interact with SSRIs, SNRIs, MAO inhibitors, tramadol, and other serotonin-raising medicines, creating a risk of serotonin excess.

Study evidence
5-HTP Supportive 18 studies
Theanine Supportive 16 studies
Valerian Supportive 18 studies
Brain Health
Brain Health
Impact
High effect
C Goal FitB- Strength of SupportC CoverageA- Formula Quality

Theanine, valerian, passionflower, and related calming ingredients may support brain health indirectly through sleep quality and stress reduction. The formula does not directly target memory, neuronal structure, or daytime performance.

The main ingredients are supplied at substantial disclosed amounts, although extract standardization is uneven. The combination is coherent for sleep, with little obvious padding, but its cognitive relevance remains secondary.

Study evidence
Theanine Supportive 17 studies
Productivity Boost
Productivity Boost
Impact
High effect
D Goal FitB+ Strength of SupportC- CoverageB+ Formula Quality
Theanine · 200 mg

Valerian, passionflower, 5-HTP, theanine, hops, and lemon balm form a coherent nighttime relaxation stack. Better sleep may indirectly support next-day productivity, but the formula is not suitable for acute daytime focus.

The relevant amounts are substantial and mostly transparent. The 200 mg 5-HTP can add serotonergic effects and should not be combined casually with SSRIs, MAO inhibitors, or other serotonin-raising medicines.

Study evidence
Theanine Supportive 5 studies
Weight Loss
Appetite and Craving Control
Weight Loss
Impact
Moderate effect
F Goal FitB+ Strength of SupportD+ CoverageA Formula Quality

Improved sleep may indirectly support appetite regulation, but the formula does not directly target fat loss. Valerian, passionflower, 5-HTP, theanine, hops, and lemon balm are better aligned with sleep than metabolism or satiety.

Most ingredients have exact and substantial amounts, and valerian includes an active-marker description. Strong sleep-formula depth does not translate into a direct weight-loss dose strategy. 5-HTP may raise serotonin excessively when combined with antidepressants such as SSRIs, SNRIs, or MAO inhibitors, while the combined sedating botanicals may impair alertness.

Study evidence
5-HTP Supportive 5 studies
Theanine Not classified

No linked studies yet.

Cognitive Support
Cognitive Support
Impact
Moderate effect
D- Goal FitB Strength of SupportD+ CoverageC Formula Quality
Theanine · 200 mg

L-theanine may support calm attention, but the formula is built primarily for sleep rather than daytime cognition. 5-HTP and several sedating botanicals further shift the effect toward nighttime relaxation.

Theanine and 5-HTP are supplied at meaningful amounts, while botanical standardization is uneven. Valerian, passionflower, hops, and 5-HTP may cause drowsiness, and 5-HTP can interact with serotonergic medicines such as SSRIs, SNRIs, MAO inhibitors, or tramadol.

Study evidence
Theanine Supportive 25 studies

Ingredients

IngredientAmount per serving
Valerian root extract (Valerenic Acids)
 800 mg
Passionflower leaf and flower extract
360 mg
5-HTP (Griffonia simplicifolia)
 200 mg
L-Theanine
200 mg
Hops flower extract
120 mg
Lemon Balm leaf extract
80 mg
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
Theanine · 200 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

Explicit L-theanine identity confirms the active isomer, but no branded source or purity testing is shown. The clearly disclosed amount falls within the optimal range for calm and focused support. A clinically dosed 5-HTP amount partly offsets the high theanine-specific cost.

View ingredientView products
Valerian (Valerenic Acids) · 800 mg OverallScore62
B- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

The named valerenic-acid marker adds specificity, though its missing percentage leaves potency uncertain. The 800 mg extract amount is higher than the usual extract range and may increase next-morning grogginess. A high extract amount does not clearly justify the premium when marker strength is unknown.

View ingredientView products
5-HTP (Griffonia simplicifolia) · 200 mg OverallScore61
B- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value

The botanical source is clearly identified, but no active standardization percentage is supplied. Vegetable capsule delivery provides a precise, convenient serving; the high-strength serving remains within the stated range, although the supplied label data include no specific serotonin-medication warning. The normalized cost is high for the disclosed active amount.

View ingredientView products
Loading alternative details
77 Performance

Sleep Support

The Vitamin Shoppe
Useful L-theanine, GABA, melatonin, and 5-HTP amounts create a strongly sleep-oriented blend with clear dosing. Raw valerian is less concentrated and the 250 mg 5-HTP amount is aggressive for routine use.
77 Performance

Lights Out Sleep

ALLMAX
Valerian, GABA, melatonin, active vitamin B6, and several calming herbs provide broader sleep coverage with mostly visible amounts. Theanine is modest, extract standards are incomplete, and 5-HTP can interact with serotonin-raising medicines.
82 Performance

Tranquil Sleep

Natural Factors Stress-Relax
Branded Suntheanine, 3 mg melatonin, and a modest 5-HTP amount create a concise bedtime formula. It omits valerian but avoids the original very high valerian and 5-HTP exposure, reducing dose intensity.
87 Budget

Sleep Regimen 3-in-1

NOW
A low serving cost combines 200 mg L-theanine, 50 mg 5-HTP, and 3 mg melatonin in a focused formula. It omits valerian, and 5-HTP can interact with serotonin-raising medicines.
75 Budget

5-HTP 100 mg

Solgar
A lower recurring cost provides a full 5-HTP amount with active vitamin B6, magnesium, and valerian. Duplicate nutrient entries complicate totals, while 5-HTP and valerian add serotonin-interaction and sedation concerns.
69 Budget

Sleep Support

Bluebonnet Targeted Choice
A much lower serving cost retains theanine, valerian, passionflower, 5-HTP, and additional calming botanicals. Doses are lighter and standards are incomplete, but the formula reduces the original high valerian and 5-HTP exposure.
75 Value

Sleep & Stress Support

Solgar
A full theanine amount with valerian, passionflower, hops, and vitamin B6 provides coherent evening support at lower recurring cost. Botanical standards are incomplete, and combined calming ingredients may intensify alcohol or sedative medicines.
71 Value

PM Formula

Nature's Way
Branded theanine, valerian, hops, and black cohosh provide a simpler nighttime formula at lower cost. Theanine and valerian amounts are modest, but the design avoids 5-HTP serotonin-interaction risk.
78 Value

Extra Strength Tranquil Sleep

Natural Factors Stress-Relax
Branded Suntheanine and a long supply support practical value at lower recurring cost. The 6 mg melatonin amount may cause next-morning effects, while the token 5-HTP still carries interaction concerns.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  2. Does valerian work for insomnia? An umbrella review of the evidence.
    Valente V; Machado D; Jorge S; Drake CL; Marques DR · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
    Systematic review8 studies pooledSleep Support forValerian
  3. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  4. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  5. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support Stress Relief forTheanine
  6. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
  7. Valerian for anxiety disorders.
    Miyasaka LS; Atallah AN; Soares BG · The Cochrane database of systematic reviews · 2007
    Systematic review36 participants1 studies pooledStress Relief forValerian
  8. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  9. Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
    Mátyus RO; Szikora Z; Bodó D; Vargáné Szabó B; Csupor É; Csupor D; Tóth B · Journal of clinical medicine · 2025
    Meta-analysis148 participants5 studies pooledMental Focus Cognitive Support forTheanine
  10. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsMental Focus Cognitive Support Productivity Boost forTheanine
  11. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  12. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  13. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support forTheanine
  14. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  15. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Productivity Boost forTheanine
  16. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  17. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support forTheanine
  18. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  19. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  20. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  21. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  22. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  23. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  24. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  25. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  26. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine
  27. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  28. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsMood Support Sleep Support Stress Relief forValerian
  29. Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
    Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
    Meta-analysis12 studies pooledMood Support forValerian
  30. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
    Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
    Meta-analysis6,894 participants60 studies pooledMood Support forValerian
  31. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
    Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
    Randomized trial20 participantsMood Support forValerian
  32. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledMood Support Stress Relief forValerian
  33. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  34. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsProductivity Boost Stress Relief forTheanine
  35. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  36. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  37. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  38. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  39. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
    Randomized trial40 participantsSleep Support forValerian
  40. Valerian for sleep: a systematic review and meta-analysis.
    Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
    Meta-analysis1,093 participants16 studies pooledSleep Support forValerian
  41. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  42. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  43. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  44. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  45. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  46. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
    Randomized trial54 participantsStress Relief forValerian
  47. Stress-induced insomnia treated with kava and valerian: singly and in combination.
    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian
  48. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  49. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  50. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  51. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  52. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP